ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GRIK1
Previous Symbol	GLUR5
Approved Name	glutamate receptor, ionotropic, kainate 1
Location	21q22
Position	chr21:30909254-31312351, -
External Links	HGNC: 4579 Entrez Gene: 2897 Ensembl: ENSG00000171189 UCSC: uc002yno.1
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lasky-Su J, 2008	1 flanking SNPs of this gene with P-value<1E-5.	Trend

Gene related SNPs (count: 6)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs363512	Chr21:31050817(Fwd)	intron_variant; nc_transcript_variant	1(0/0/1)

LD-proxies (count: 5)

rs_ID	Location	Functional Annotation
rs363522	Chr21:31023226(Fwd)	intron_variant; nc_transcript_variant
rs2268206	Chr21:31039378(Fwd)	intron_variant; nc_transcript_variant
rs363544	Chr21:31050277(Fwd)	intron_variant; nc_transcript_variant
rs363564	Chr21:31035432(Fwd)	intron_variant; nc_transcript_variant
rs9981377	Chr21:31030797(Fwd)	intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 23)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035249	synaptic transmission, glutamatergic	Biological Process		7
GO:0032983	kainate selective glutamate receptor complex	Cellular Component		3
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0042734	presynaptic membrane	Cellular Component		15
GO:0051966	regulation of synaptic transmission, glutamatergic	Biological Process	TAS[9335499]	2
GO:0048266	behavioral response to pain	Biological Process		4
GO:0060079	regulation of excitatory postsynaptic membrane potential	Biological Process		9
GO:0051967	negative regulation of synaptic transmission, glutamatergic	Biological Process		5
GO:0060080	regulation of inhibitory postsynaptic membrane potential	Biological Process		5
GO:0005234	extracellular-glutamate-gated ion channel activity	Molecular Function		8
GO:0005886	plasma membrane	Cellular Component		772
GO:0007215	glutamate receptor signaling pathway	Biological Process	TAS[8260617]	6
GO:0007268	synaptic transmission	Biological Process		96
GO:0005887	integral to plasma membrane	Cellular Component	TAS[8260617]	220
GO:0006810	transport	Biological Process	TAS[8260617]	62
GO:0014054	positive regulation of gamma-aminobutyric acid secretion	Biological Process		3
GO:0015277	kainate selective glutamate receptor activity	Molecular Function	IDA[9335499]	3
GO:0007399	nervous system development	Biological Process	TAS[8260617]	54
GO:0007417	central nervous system development	Biological Process	TAS[10580501]	22
GO:0030534	adult behavior	Biological Process		5
GO:0032230	positive regulation of synaptic transmission, GABAergic	Biological Process		4
GO:0030054	cell junction	Cellular Component		77
GO:0030425	dendrite	Cellular Component		46

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04724	Glutamatergic synapse	43	Glutamate is the major excitatory neurotransmitter in the ma...... Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synaptic cleft, glutamate acts on postsynaptic ionotropic glutamate receptors (iGluRs) to mediate fast excitatory synaptic transmission. Glutamate can also act on metabotropic glutamate receptors (mGluRs) and exert a variety of modulatory effects through their coupling to G proteins and the subsequent recruitment of second messenger systems. Presynaptically localized Group II and Group III mGluRs are thought to represent the classical inhibitory autoreceptor mechanism that suppresses excess glutamate release. After its action on these receptors, glutamate can be removed from the synaptic cleft by EAATs located either on the presynaptic terminal, neighboring glial cells, or the postsynaptic neuron. In glia, glutamate is converted to glutamine, which is then transported back to the presynaptic terminal and converted back to glutamate. More...

Genes shared at least 5 GO terms with GRIK1 (count: 23)

Gene Symbol	Pathway Count	Pathway List
GRIK4	11	kainate selective glutamate receptor complex; postsynaptic membrane; presynaptic membrane; extracellular-glutamate-gated ion channel activity; plasma membrane; glutamate receptor signaling pathway; synaptic transmission; integral to plasma membrane; transport; kainate selective glutamate receptor activity; cell junction;
GRIA4	10	kainate selective glutamate receptor complex; postsynaptic membrane; extracellular-glutamate-gated ion channel activity; plasma membrane; glutamate receptor signaling pathway; synaptic transmission; transport; kainate selective glutamate receptor activity; cell junction; dendrite;
GRIN2A	10	postsynaptic membrane; presynaptic membrane; regulation of excitatory postsynaptic membrane potential; extracellular-glutamate-gated ion channel activity; plasma membrane; glutamate receptor signaling pathway; synaptic transmission; integral to plasma membrane; transport; cell junction;
GRIN2B	10	postsynaptic membrane; behavioral response to pain; regulation of excitatory postsynaptic membrane potential; extracellular-glutamate-gated ion channel activity; plasma membrane; glutamate receptor signaling pathway; synaptic transmission; integral to plasma membrane; transport; cell junction;
ADORA2A	9	synaptic transmission, glutamatergic; postsynaptic membrane; presynaptic membrane; regulation of excitatory postsynaptic membrane potential; regulation of inhibitory postsynaptic membrane potential; plasma membrane; integral to plasma membrane; central nervous system development; positive regulation of synaptic transmission, GABAergic;
GRID2	9	synaptic transmission, glutamatergic; postsynaptic membrane; regulation of excitatory postsynaptic membrane potential; extracellular-glutamate-gated ion channel activity; plasma membrane; glutamate receptor signaling pathway; integral to plasma membrane; transport; cell junction;
ACHE	7	postsynaptic membrane; presynaptic membrane; plasma membrane; synaptic transmission; nervous system development; cell junction; dendrite;
CHRNA3	7	postsynaptic membrane; regulation of excitatory postsynaptic membrane potential; plasma membrane; synaptic transmission; nervous system development; cell junction; dendrite;
GABRA5	7	postsynaptic membrane; plasma membrane; synaptic transmission; integral to plasma membrane; transport; cell junction; dendrite;
GRM7	7	postsynaptic membrane; presynaptic membrane; plasma membrane; synaptic transmission; integral to plasma membrane; adult behavior; dendrite;
CHRM3	6	postsynaptic membrane; plasma membrane; integral to plasma membrane; nervous system development; cell junction; dendrite;
CHRNA4	6	postsynaptic membrane; regulation of inhibitory postsynaptic membrane potential; plasma membrane; synaptic transmission; cell junction; dendrite;
GABRB3	6	postsynaptic membrane; plasma membrane; synaptic transmission; integral to plasma membrane; transport; cell junction;
HTR3A	6	postsynaptic membrane; plasma membrane; synaptic transmission; integral to plasma membrane; transport; cell junction;
NLGN1	6	postsynaptic membrane; integral to plasma membrane; nervous system development; positive regulation of synaptic transmission, GABAergic; cell junction; dendrite;
CHRM1	5	postsynaptic membrane; plasma membrane; integral to plasma membrane; nervous system development; cell junction;
CHRNA5	5	postsynaptic membrane; plasma membrane; synaptic transmission; transport; cell junction;
CHRNB4	5	postsynaptic membrane; plasma membrane; synaptic transmission; integral to plasma membrane; cell junction;
GABBR2	5	postsynaptic membrane; plasma membrane; synaptic transmission; integral to plasma membrane; cell junction;
HTR3B	5	postsynaptic membrane; plasma membrane; synaptic transmission; integral to plasma membrane; transport;
NRXN1	5	presynaptic membrane; plasma membrane; integral to plasma membrane; adult behavior; cell junction;
HTR6	5	plasma membrane; synaptic transmission; integral to plasma membrane; positive regulation of gamma-aminobutyric acid secretion; dendrite;
SLC6A1	5	plasma membrane; synaptic transmission; integral to plasma membrane; transport; positive regulation of gamma-aminobutyric acid secretion;

Genes shared at least 2 KEGG pathways with GRIK1 (count: 10)

Gene Symbol	Pathway Count	Pathway List
GRIA4	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIK4	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIN2A	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIN2B	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIN3A	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM1	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM5	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM6	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM7	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM8	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;

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Region: chr21:30909254..31312351 View in gBrowse