ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NLGN1
Symbol Alias	KIAA1070
Approved Name	neuroligin 1
Location	3q26.32
Position	chr3:173114074-174004434, +
External Links	HGNC: 14291 Entrez Gene: 22871 Ensembl: ENSG00000169760 UCSC: uc003fio.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_19	chr3:174547344-176016137 (NCBI Build 36.1 (hg18))	1468793	3q26.31	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 49)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004091	carboxylesterase activity	Molecular Function		40

GO terms by database search (count: 48)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0060999	positive regulation of dendritic spine development	Biological Process		2
GO:0051968	positive regulation of synaptic transmission, glutamatergic	Biological Process		8
GO:0097091	synaptic vesicle clustering	Biological Process		2
GO:0072553	terminal button organization	Biological Process		1
GO:0051290	protein heterotetramerization	Biological Process		1
GO:0051260	protein homooligomerization	Biological Process		34
GO:0051965	positive regulation of synapse assembly	Biological Process		4
GO:0051491	positive regulation of filopodium assembly	Biological Process		5
GO:0097119	postsynaptic density protein 95 clustering	Biological Process		3
GO:0097115	neurexin clustering	Biological Process		1
GO:1900029	positive regulation of ruffle assembly	Biological Process		1
GO:0097120	receptor localization to synapse	Biological Process		3
GO:0097105	presynaptic membrane assembly	Biological Process		3
GO:0097104	postsynaptic membrane assembly	Biological Process		3
GO:0097114	N-methyl-D-aspartate receptor clustering	Biological Process		2
GO:0097113	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering	Biological Process		1
GO:2000463	positive regulation of excitatory postsynaptic membrane potential	Biological Process		2
GO:1900244	positive regulation of synaptic vesicle endocytosis	Biological Process		1
GO:2000302	positive regulation of synaptic vesicle exocytosis	Biological Process		1
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	Biological Process		3
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	Biological Process		6
GO:0005887	integral to plasma membrane	Cellular Component		220
GO:0004872	receptor activity	Molecular Function		36
GO:0002087	regulation of respiratory gaseous exchange by neurological system process	Biological Process		2
GO:0014069	postsynaptic density	Cellular Component	TAS[15797875]	23
GO:0010740	positive regulation of intracellular protein kinase cascade	Biological Process		2
GO:0009986	cell surface	Cellular Component		70
GO:0007416	synapse assembly	Biological Process		6
GO:0007399	nervous system development	Biological Process		54
GO:0007158	neuron cell-cell adhesion	Biological Process	TAS[15797875]	5
GO:0007157	heterophilic cell-cell adhesion	Biological Process		11
GO:0006605	protein targeting	Biological Process		5
GO:0032230	positive regulation of synaptic transmission, GABAergic	Biological Process		4
GO:0032433	filopodium tip	Cellular Component		2
GO:0030054	cell junction	Cellular Component		77
GO:0030425	dendrite	Cellular Component		46
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex	Cellular Component		4
GO:0023041	neuronal signal transduction	Biological Process	TAS[15797875]	2
GO:0016080	synaptic vesicle targeting	Biological Process		2
GO:0016339	calcium-dependent cell-cell adhesion	Biological Process		8
GO:0048789	cytoskeletal matrix organization at active zone	Biological Process		1
GO:0050839	cell adhesion molecule binding	Molecular Function		9
GO:0045664	regulation of neuron differentiation	Biological Process		4
GO:0046983	protein dimerization activity	Molecular Function		26
GO:0045202	synapse	Cellular Component		31
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0042043	neurexin family protein binding	Molecular Function		2
GO:0045184	establishment of protein localization	Biological Process		4

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04514	Cell adhesion molecules (CAMs)	20	Cell adhesion molecules are (glyco)proteins expressed on the...... Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. More...

Genes shared at least 5 GO terms with NLGN1 (count: 12)

Gene Symbol	Pathway Count	Pathway List
NRXN1	21	positive regulation of synaptic transmission, glutamatergic; synaptic vesicle clustering; positive regulation of synapse assembly; postsynaptic density protein 95 clustering; receptor localization to synapse; presynaptic membrane assembly; postsynaptic membrane assembly; N-methyl-D-aspartate receptor clustering; positive regulation of excitatory postsynaptic membrane potential; regulation of N-methyl-D-aspartate selective glutamate receptor activity; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; integral to plasma membrane; receptor activity; cell surface; neuron cell-cell adhesion; heterophilic cell-cell adhesion; cell junction; neuronal signal transduction; calcium-dependent cell-cell adhesion; cell adhesion molecule binding; establishment of protein localization;
ACHE	8	carboxylesterase activity; cell surface; synapse assembly; nervous system development; cell junction; dendrite; synapse; postsynaptic membrane;
CHRM3	6	integral to plasma membrane; receptor activity; nervous system development; cell junction; dendrite; postsynaptic membrane;
GRIK1	6	integral to plasma membrane; nervous system development; positive regulation of synaptic transmission, GABAergic; cell junction; dendrite; postsynaptic membrane;
GRIN2A	6	integral to plasma membrane; postsynaptic density; cell surface; cell junction; N-methyl-D-aspartate selective glutamate receptor complex; postsynaptic membrane;
GRIN2B	6	integral to plasma membrane; postsynaptic density; cell surface; cell junction; N-methyl-D-aspartate selective glutamate receptor complex; postsynaptic membrane;
ADORA2A	5	positive regulation of synaptic transmission, glutamatergic; integral to plasma membrane; postsynaptic density; positive regulation of synaptic transmission, GABAergic; postsynaptic membrane;
CNIH2	5	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; postsynaptic density; cell junction; dendrite; postsynaptic membrane;
CHRM1	5	integral to plasma membrane; postsynaptic density; nervous system development; cell junction; postsynaptic membrane;
GABRA5	5	integral to plasma membrane; receptor activity; cell junction; dendrite; postsynaptic membrane;
CHRNA3	5	postsynaptic density; nervous system development; cell junction; dendrite; postsynaptic membrane;
GRIN3A	5	postsynaptic density; cell junction; N-methyl-D-aspartate selective glutamate receptor complex; synapse; postsynaptic membrane;

Genes shared at least 2 KEGG pathways with NLGN1 (count: 0)

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Region: chr3:173114074..174004434 View in gBrowse