ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NLGN1
Symbol Alias	KIAA1070
Approved Name	neuroligin 1
Location	3q26.32
Position	chr3:173114074-174004434, 1
External Links	HGNC: 14291 Entrez Gene: 22871 Ensembl: ENSG00000169760 UCSC: uc003fio.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_19	chr3:174547344-176016137 (NCBI Build 36.1 (hg18))	1468793	3q26.31	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 49)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004091	carboxylesterase activity	molecular function	IKR	14

GO terms by database search (count: 48)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045211	postsynaptic membrane	cellular component	IEA	45
GO:0050839	cell adhesion molecule binding	molecular function	ISS	9
GO:0002087	regulation of respiratory gaseous exchange by neurological system process	biological process	IEA	2
GO:0051260	protein homooligomerization	biological process	ISS	38
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	biological process	ISS	3
GO:0097105	presynaptic membrane assembly	biological process	ISS	3
GO:0097104	postsynaptic membrane assembly	biological process	ISS	3
GO:0032230	positive regulation of synaptic transmission, GABAergic	biological process	ISS	4
GO:0046983	protein dimerization activity	molecular function	ISS	28
GO:0097113	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor clustering	biological process	ISS	1
GO:0042043	neurexin family protein binding	molecular function	IBA; ISS	2
GO:0007416	synapse assembly	biological process	IBA; ISS	7
GO:0045664	regulation of neuron differentiation	biological process	ISS	3
GO:2000463	positive regulation of excitatory postsynaptic membrane potential	biological process	ISS	2
GO:0016339	calcium-dependent cell-cell adhesion	biological process	ISS	8
GO:0097115	neurexin clustering	biological process	ISS	1
GO:0014069	postsynaptic density	cellular component	TAS[15797875]	26
GO:0097114	N-methyl-D-aspartate receptor clustering	biological process	IEA	2
GO:0010740	positive regulation of intracellular protein kinase cascade	biological process	ISS	2
GO:0060999	positive regulation of dendritic spine development	biological process	ISS	2
GO:0004872	receptor activity	molecular function	IBA; ISS	38
GO:0007157	heterophilic cell-cell adhesion	biological process	ISS	11
GO:0045202	synapse	cellular component	IBA; ISS	35
GO:0016080	synaptic vesicle targeting	biological process	ISS	2
GO:0097091	synaptic vesicle clustering	biological process	ISS	2
GO:0032433	filopodium tip	cellular component	IEA	3
GO:2000302	positive regulation of synaptic vesicle exocytosis	biological process	ISS	1
GO:0023041	neuronal signal transduction	biological process	TAS[15797875]	2
GO:0072553	terminal button organization	biological process	ISS	1
GO:0051965	positive regulation of synapse assembly	biological process	ISS	4
GO:0045184	establishment of protein localization	biological process	ISS	4
GO:1900244	positive regulation of synaptic vesicle endocytosis	biological process	ISS	1
GO:0009986	cell surface	cellular component	IBA; ISS	75
GO:0097120	receptor localization to synapse	biological process	ISS	3
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	biological process	ISS	6
GO:0051968	positive regulation of synaptic transmission, glutamatergic	biological process	ISS	8
GO:0006605	protein targeting	biological process	ISS	5
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex	cellular component	IEA	4
GO:0007158	neuron cell-cell adhesion	biological process	ISS; TAS[15797875]	5
GO:0097119	postsynaptic density protein 95 clustering	biological process	ISS	3
GO:0007399	nervous system development	biological process	ISS	60
GO:0051491	positive regulation of filopodium assembly	biological process	ISS	5
GO:0030054	cell junction	cellular component	IEA	84
GO:0048789	cytoskeletal matrix organization at active zone	biological process	ISS	1
GO:0005887	integral to plasma membrane	cellular component	IBA; ISS	236
GO:1900029	positive regulation of ruffle assembly	biological process	ISS	1
GO:0051290	protein heterotetramerization	biological process	IEA	1
GO:0030425	dendrite	cellular component	ISS	51

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04514	Cell adhesion molecules (CAMs)	27

Genes shared at least 5 GO terms with NLGN1 (count: 12)

Gene Symbol	Pathway Count	Pathway List
NRXN1	21	cell adhesion molecule binding; regulation of N-methyl-D-aspartate selective glutamate receptor activity; presynaptic membrane assembly; postsynaptic membrane assembly; positive regulation of excitatory postsynaptic membrane potential; calcium-dependent cell-cell adhesion; N-methyl-D-aspartate receptor clustering; receptor activity; heterophilic cell-cell adhesion; synaptic vesicle clustering; neuronal signal transduction; positive regulation of synapse assembly; establishment of protein localization; cell surface; receptor localization to synapse; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; positive regulation of synaptic transmission, glutamatergic; neuron cell-cell adhesion; postsynaptic density protein 95 clustering; cell junction; integral to plasma membrane;
ACHE	8	postsynaptic membrane; carboxylesterase activity; synapse assembly; synapse; cell surface; nervous system development; cell junction; dendrite;
GRIK1	6	postsynaptic membrane; positive regulation of synaptic transmission, GABAergic; nervous system development; cell junction; integral to plasma membrane; dendrite;
GRIN2A	6	postsynaptic membrane; postsynaptic density; cell surface; N-methyl-D-aspartate selective glutamate receptor complex; cell junction; integral to plasma membrane;
GRIN2B	6	postsynaptic membrane; postsynaptic density; cell surface; N-methyl-D-aspartate selective glutamate receptor complex; cell junction; integral to plasma membrane;
CHRM3	6	postsynaptic membrane; receptor activity; nervous system development; cell junction; integral to plasma membrane; dendrite;
CHRNA3	5	postsynaptic membrane; postsynaptic density; nervous system development; cell junction; dendrite;
ADORA2A	5	postsynaptic membrane; positive regulation of synaptic transmission, GABAergic; postsynaptic density; positive regulation of synaptic transmission, glutamatergic; integral to plasma membrane;
CHRM1	5	postsynaptic membrane; postsynaptic density; nervous system development; cell junction; integral to plasma membrane;
GABRA5	5	postsynaptic membrane; receptor activity; cell junction; integral to plasma membrane; dendrite;
GRIN3A	5	postsynaptic membrane; postsynaptic density; synapse; N-methyl-D-aspartate selective glutamate receptor complex; cell junction;
CNIH2	5	postsynaptic membrane; postsynaptic density; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; cell junction; dendrite;

Genes shared at least 2 KEGG pathways with NLGN1 (count: 0)

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Region: chr3:173114074..174004434 View in gBrowse