ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0004091
Name carboxylesterase activity
Type molecular function
No. of Genes in ADHDgene  14
Source Pathway by PBA (with statistical significance of FDR<0.05)

PBA Result (with statistical significance of FDR<0.05)
Data Set Reference Gene Set Mapping Rule P-value FDR Result Link
Neale BM, 2008 MsigDB 3.0 c5.mf 5kb upstream and downstream of gene < 0.001 0.008 Link

Comments for this pathway (count: 1)
PMID Citation Comment
19733552 Nemoda Z, Angyal N,et al. Carboxylesterase 1 gene polymorphism and methylphenidate response in ADHD. Neuropharmacology 2009, 57(7-8):731-733. This result warrants for further investigations of the CES1 ...... This result warrants for further investigations of the CES1 gene in larger ADHD samples. More...

GO related genes in ADHDgene (count: 14)

Literature-origin genes (count: 1)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
BCHE butyrylcholinesterase 3q26.1-q26.2 1(1/0/0) IBA

Genes from other sources Help (count: 13)

Approved Symbol Approved Name Source Evidence[PMID]
ABHD3 abhydrolase domain containing 3 Mapped by significant region IEA
AADAC arylacetamide deacetylase Mapped by PBA pathway IEA
ACHE acetylcholinesterase (Yt blood group) Mapped by PBA pathway IBA
CES1 carboxylesterase 1 Mapped by PBA pathway IBA
MGLL monoglyceride lipase Mapped by PBA pathway IEA
NLGN1 neuroligin 1 Mapped by CNV IKR
BAAT bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) Mapped by significant region IEA
CES2 carboxylesterase 2 Mapped by PBA pathway IBA
LGALS13 lectin, galactoside-binding, soluble, 13 Mapped by PBA pathway IEA
SIAE sialic acid acetylesterase Mapped by significant region IEA
ABHD15 abhydrolase domain containing 15 Mapped by LD-proxy IEA
PPME1 protein phosphatase methylesterase 1 Mapped by significant region; Mapped by PBA pathway IEA
CES5A carboxylesterase 5A Mapped by LD-proxy IBA