ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PLA2G2D
Symbol Alias	sPLA2S
Approved Name	phospholipase A2, group IID
Location	1p36.12
Position	chr1:20438432-20446050, -1
External Links	HGNC: 9033 Entrez Gene: 26279 Ensembl: ENSG00000117215 UCSC: uc001bcz.4
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0005576	extracellular region	cellular component	TAS	267
GO:0006954	inflammatory response	biological process	TAS[10455175]	54
GO:0006644	phospholipid metabolic process	biological process	TAS	61
GO:0005509	calcium ion binding	molecular function	IEA	140
GO:0004623	phospholipase A2 activity	molecular function	IEA	10
GO:0036149	phosphatidylinositol acyl-chain remodeling	biological process	TAS	8
GO:0036148	phosphatidylglycerol acyl-chain remodeling	biological process	TAS	10
GO:0036151	phosphatidylcholine acyl-chain remodeling	biological process	TAS	15
GO:0036152	phosphatidylethanolamine acyl-chain remodeling	biological process	TAS	15
GO:0016042	lipid catabolic process	biological process	IEA	32
GO:0036150	phosphatidylserine acyl-chain remodeling	biological process	TAS	10
GO:0046474	glycerophospholipid biosynthetic process	biological process	TAS	30
GO:0006654	phosphatidic acid biosynthetic process	biological process	TAS	12

Gene related KEGG pathways (count: 10)

ID	Name	No. of Genes in ADHDgene
hsa04370	VEGF signaling pathway	18
hsa04010	MAPK signaling pathway	68
hsa04664	Fc epsilon RI signaling pathway	19
hsa04730	Long-term depression	27
hsa00564	Glycerophospholipid metabolism	21
hsa04912	GnRH signaling pathway	30
hsa00592	alpha-Linolenic acid metabolism	10
hsa00591	Linoleic acid metabolism	11
hsa00590	Arachidonic acid metabolism	15
hsa00565	Ether lipid metabolism	13

Genes shared at least 5 GO terms with PLA2G2D (count: 17)

Gene Symbol	Pathway Count	Pathway List
PLA2G2E	14	small molecule metabolic process; extracellular region; inflammatory response; phospholipid metabolic process; calcium ion binding; phospholipase A2 activity; phosphatidylinositol acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; lipid catabolic process; phosphatidylserine acyl-chain remodeling; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process;
PLA2G10	13	small molecule metabolic process; extracellular region; phospholipid metabolic process; calcium ion binding; phospholipase A2 activity; phosphatidylinositol acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; lipid catabolic process; phosphatidylserine acyl-chain remodeling; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process;
PLA2G2A	13	small molecule metabolic process; extracellular region; phospholipid metabolic process; calcium ion binding; phospholipase A2 activity; phosphatidylinositol acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; lipid catabolic process; phosphatidylserine acyl-chain remodeling; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process;
PLA2G1B	12	small molecule metabolic process; extracellular region; phospholipid metabolic process; calcium ion binding; phospholipase A2 activity; phosphatidylinositol acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process;
PLA2G5	12	small molecule metabolic process; extracellular region; phospholipid metabolic process; calcium ion binding; phosphatidylinositol acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; lipid catabolic process; phosphatidylserine acyl-chain remodeling; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process;
PLA2G4B	11	small molecule metabolic process; extracellular region; inflammatory response; phospholipid metabolic process; calcium ion binding; phosphatidylglycerol acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process;
LPCAT4	9	small molecule metabolic process; phospholipid metabolic process; calcium ion binding; phosphatidylglycerol acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process;
PLA2G3	9	small molecule metabolic process; extracellular region; phospholipid metabolic process; calcium ion binding; phosphatidylglycerol acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; lipid catabolic process; glycerophospholipid biosynthetic process;
PLA2G16	9	small molecule metabolic process; phospholipid metabolic process; phospholipase A2 activity; phosphatidylinositol acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; lipid catabolic process; phosphatidylserine acyl-chain remodeling; glycerophospholipid biosynthetic process;
PLA2G4C	7	small molecule metabolic process; inflammatory response; phospholipid metabolic process; phosphatidylinositol acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; glycerophospholipid biosynthetic process;
PLA2G6	7	small molecule metabolic process; phospholipid metabolic process; phospholipase A2 activity; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; lipid catabolic process; glycerophospholipid biosynthetic process;
LPCAT1	7	small molecule metabolic process; phospholipid metabolic process; calcium ion binding; phosphatidylglycerol acyl-chain remodeling; phosphatidylcholine acyl-chain remodeling; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process;
PNPLA8	5	small molecule metabolic process; phospholipid metabolic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; glycerophospholipid biosynthetic process;
PLD1	5	small molecule metabolic process; phospholipid metabolic process; lipid catabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process;
MBOAT1	5	small molecule metabolic process; phospholipid metabolic process; phosphatidylethanolamine acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; glycerophospholipid biosynthetic process;
MBOAT2	5	small molecule metabolic process; phospholipid metabolic process; phosphatidylcholine acyl-chain remodeling; phosphatidylethanolamine acyl-chain remodeling; glycerophospholipid biosynthetic process;
PLD2	5	small molecule metabolic process; phospholipid metabolic process; lipid catabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process;

Genes shared at least 2 KEGG pathways with PLA2G2D (count: 30)

Gene Symbol	Pathway Count	Pathway List
PLA2G6	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
PLA2G5	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
PLA2G2E	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
PLA2G10	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
PLA2G4B	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
PLA2G2A	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
PLA2G1B	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
PLA2G3	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
MAPK3	5	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; GnRH signaling pathway;
MAPK1	5	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; GnRH signaling pathway;
MAP2K3	3	MAPK signaling pathway; Fc epsilon RI signaling pathway; GnRH signaling pathway;
MAPK9	3	MAPK signaling pathway; Fc epsilon RI signaling pathway; GnRH signaling pathway;
PLD1	3	Glycerophospholipid metabolism; GnRH signaling pathway; Ether lipid metabolism;
PLD2	3	Glycerophospholipid metabolism; GnRH signaling pathway; Ether lipid metabolism;
PPP3R2	2	VEGF signaling pathway; MAPK signaling pathway;
PIK3CG	2	VEGF signaling pathway; Fc epsilon RI signaling pathway;
NFATC4	2	VEGF signaling pathway; MAPK signaling pathway;
PLCG2	2	VEGF signaling pathway; Fc epsilon RI signaling pathway;
PIK3R1	2	VEGF signaling pathway; Fc epsilon RI signaling pathway;
CACNA1D	2	MAPK signaling pathway; GnRH signaling pathway;
MAPK7	2	MAPK signaling pathway; GnRH signaling pathway;
CACNA1A	2	MAPK signaling pathway; Long-term depression;
CACNA1C	2	MAPK signaling pathway; GnRH signaling pathway;
CACNA1F	2	MAPK signaling pathway; GnRH signaling pathway;
CACNA1S	2	MAPK signaling pathway; GnRH signaling pathway;
PLCB3	2	Long-term depression; GnRH signaling pathway;
ITPR2	2	Long-term depression; GnRH signaling pathway;
ITPR1	2	Long-term depression; GnRH signaling pathway;
PLCB2	2	Long-term depression; GnRH signaling pathway;
CYP2E1	2	Linoleic acid metabolism; Arachidonic acid metabolism;

View in gBrowse

Region: chr1:20438432..20446050 View in gBrowse