ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04972
Name Pancreatic secretion
Description  The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
No. of Genes in ADHDgene  30
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 30)

Literature-origin genes (count: 1)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 Xq28 1(0/1/0)

Genes from other sources Help(count: 29)

Approved Symbol Approved Name Location Source
PRKCB protein kinase C, beta 16p12 Mapped by significant region
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1p35 Mapped by PBA pathway
PLA2G1B phospholipase A2, group IB (pancreas) 12q23-qter Mapped by PBA pathway
CCKAR cholecystokinin A receptor 4 Mapped by CNV
PLA2G2E phospholipase A2, group IIE 1p36.13 Mapped by PBA pathway
PLA2G2D phospholipase A2, group IID 1p36.12 Mapped by PBA pathway
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 3p26.1 Mapped by CNV
PLA2G4B phospholipase A2, group IVB (cytosolic) 15q11.2-q21.3 Mapped by PBA pathway
PLA2G3 phospholipase A2, group III 22q12.2 Mapped by PBA pathway
PLA2G5 phospholipase A2, group V 1p36-p34 Mapped by PBA pathway
TRPC1 transient receptor potential cation channel, subfamily C, member 1 3q23 Mapped by PBA pathway
PLCB2 phospholipase C, beta 2 15q15 Mapped by PBA pathway
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 22q13.1 Mapped by PBA pathway
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 12p11.23 Mapped by LD-proxy; Mapped by literature SNP
CA2 carbonic anhydrase II 8q22 Mapped by CNV
CHRM3 cholinergic receptor, muscarinic 3 1q41-q44 Mapped by CNV; Mapped by PBA pathway
RYR2 ryanodine receptor 2 (cardiac) 1q43 Mapped by CNV; Mapped by PBA pathway
SCTR secretin receptor 2q14.1 Mapped by LD-proxy
PLA2G10 phospholipase A2, group X 16p13.1-p12 Mapped by PBA pathway; Mapped by significant region
PNLIP pancreatic lipase 10q25.3 Mapped by PBA pathway
PNLIPRP1 pancreatic lipase-related protein 1 10q26.12 Mapped by PBA pathway
FXYD2 FXYD domain containing ion transport regulator 2 11q23 Mapped by significant region
TPCN2 two pore segment channel 2 11q13.1 Mapped by CNV; Mapped by significant region
SLC4A2 solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) 7q35-q36 Mapped by LD-proxy; Mapped by literature SNP
CTRB1 chymotrypsinogen B1 16q23.1 Mapped by significant region
PNLIPRP2 pancreatic lipase-related protein 2 10q26.12 Mapped by PBA pathway
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 11q13 Mapped by significant region
RAB27B RAB27B, member RAS oncogene family 18q21.2 Mapped by LD-proxy; Mapped by literature SNP
ADCY4 adenylate cyclase 4 14q11.2 Mapped by significant region

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014