ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TRPC1
Symbol Alias	HTRP-1
Approved Name	transient receptor potential cation channel, subfamily C, member 1
Location	3q23
Position	chr3:142442916-142526730, +
External Links	HGNC: 12333 Entrez Gene: 7220 Ensembl: ENSG00000144935 UCSC: uc003evb.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005262	calcium channel activity	Molecular Function	TAS[8646775]	40

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	Molecular Function	IPI[14505576]	910
GO:0005886	plasma membrane	Cellular Component	IDA[14505576]	772
GO:0005887	integral to plasma membrane	Cellular Component	TAS[7568191]	220
GO:0005261	cation channel activity	Molecular Function		2
GO:0030017	sarcomere	Cellular Component		4
GO:0043034	costamere	Cellular Component		4
GO:0043234	protein complex	Cellular Component		45
GO:0044325	ion channel binding	Molecular Function	IPI[10097141]	15
GO:0006816	calcium ion transport	Biological Process	TAS[8646775]	32
GO:0007411	axon guidance	Biological Process		65
GO:0015279	store-operated calcium channel activity	Molecular Function		7
GO:0016323	basolateral plasma membrane	Cellular Component		29
GO:0051480	cytosolic calcium ion homeostasis	Biological Process	IDA[19052258]	6
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	Biological Process	IDA[19052258]	5
GO:0046541	saliva secretion	Biological Process		1
GO:0045121	membrane raft	Cellular Component		22
GO:0070679	inositol 1,4,5 trisphosphate binding	Molecular Function	IDA[14505576]	5
GO:0051592	response to calcium ion	Biological Process	IDA[14505576]	9

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04972	Pancreatic secretion	30	The pancreas performs both exocrine and endocrine functions....... The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion. More...
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...
hsa04724	Glutamatergic synapse	43	Glutamate is the major excitatory neurotransmitter in the ma...... Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synaptic cleft, glutamate acts on postsynaptic ionotropic glutamate receptors (iGluRs) to mediate fast excitatory synaptic transmission. Glutamate can also act on metabotropic glutamate receptors (mGluRs) and exert a variety of modulatory effects through their coupling to G proteins and the subsequent recruitment of second messenger systems. Presynaptically localized Group II and Group III mGluRs are thought to represent the classical inhibitory autoreceptor mechanism that suppresses excess glutamate release. After its action on these receptors, glutamate can be removed from the synaptic cleft by EAATs located either on the presynaptic terminal, neighboring glial cells, or the postsynaptic neuron. In glia, glutamate is converted to glutamine, which is then transported back to the presynaptic terminal and converted back to glutamate. More...

Genes shared at least 5 GO terms with TRPC1 (count: 13)

Gene Symbol	Pathway Count	Pathway List
TRPC3	9	calcium channel activity; protein binding; plasma membrane; integral to plasma membrane; calcium ion transport; axon guidance; store-operated calcium channel activity; inositol 1,4,5 trisphosphate binding; response to calcium ion;
TRPC4	8	calcium channel activity; protein binding; plasma membrane; calcium ion transport; axon guidance; store-operated calcium channel activity; basolateral plasma membrane; inositol 1,4,5 trisphosphate binding;
RYR2	7	calcium channel activity; protein binding; plasma membrane; protein complex; ion channel binding; calcium ion transport; cytosolic calcium ion homeostasis;
TRPC5	7	calcium channel activity; protein binding; integral to plasma membrane; calcium ion transport; axon guidance; store-operated calcium channel activity; inositol 1,4,5 trisphosphate binding;
ANK3	6	protein binding; plasma membrane; costamere; ion channel binding; axon guidance; basolateral plasma membrane;
CACNB2	5	calcium channel activity; protein binding; integral to plasma membrane; calcium ion transport; axon guidance;
ORAI1	5	calcium channel activity; protein binding; integral to plasma membrane; protein complex; store-operated calcium channel activity;
PANX1	5	calcium channel activity; plasma membrane; protein complex; ion channel binding; calcium ion transport;
RYR1	5	calcium channel activity; plasma membrane; integral to plasma membrane; calcium ion transport; cytosolic calcium ion homeostasis;
ILK	5	protein binding; plasma membrane; sarcomere; costamere; protein complex;
SLC22A6	5	protein binding; plasma membrane; integral to plasma membrane; protein complex; basolateral plasma membrane;
THY1	5	protein binding; plasma membrane; integral to plasma membrane; positive regulation of release of sequestered calcium ion into cytosol; membrane raft;
TRPC6	5	protein binding; plasma membrane; axon guidance; store-operated calcium channel activity; inositol 1,4,5 trisphosphate binding;

Genes shared at least 2 KEGG pathways with TRPC1 (count: 26)

Gene Symbol	Pathway Count	Pathway List
ADCY4	3	Pancreatic secretion; Calcium signaling pathway; Glutamatergic synapse;
ITPR1	3	Pancreatic secretion; Calcium signaling pathway; Glutamatergic synapse;
ITPR2	3	Pancreatic secretion; Calcium signaling pathway; Glutamatergic synapse;
PLCB2	3	Pancreatic secretion; Calcium signaling pathway; Glutamatergic synapse;
PLCB3	3	Pancreatic secretion; Calcium signaling pathway; Glutamatergic synapse;
PRKCB	3	Pancreatic secretion; Calcium signaling pathway; Glutamatergic synapse;
ATP2B3	2	Pancreatic secretion; Calcium signaling pathway;
CCKAR	2	Pancreatic secretion; Calcium signaling pathway;
CHRM3	2	Pancreatic secretion; Calcium signaling pathway;
PLA2G10	2	Pancreatic secretion; Glutamatergic synapse;
PLA2G1B	2	Pancreatic secretion; Glutamatergic synapse;
PLA2G2A	2	Pancreatic secretion; Glutamatergic synapse;
PLA2G2D	2	Pancreatic secretion; Glutamatergic synapse;
PLA2G2E	2	Pancreatic secretion; Glutamatergic synapse;
PLA2G3	2	Pancreatic secretion; Glutamatergic synapse;
PLA2G4B	2	Pancreatic secretion; Glutamatergic synapse;
PLA2G5	2	Pancreatic secretion; Glutamatergic synapse;
PLA2G6	2	Pancreatic secretion; Glutamatergic synapse;
RYR2	2	Pancreatic secretion; Calcium signaling pathway;
CACNA1A	2	Calcium signaling pathway; Glutamatergic synapse;
CACNA1C	2	Calcium signaling pathway; Glutamatergic synapse;
CACNA1D	2	Calcium signaling pathway; Glutamatergic synapse;
GRIN2A	2	Calcium signaling pathway; Glutamatergic synapse;
GRM1	2	Calcium signaling pathway; Glutamatergic synapse;
GRM5	2	Calcium signaling pathway; Glutamatergic synapse;
PPP3R2	2	Calcium signaling pathway; Glutamatergic synapse;

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Region: chr3:142442916..142526730 View in gBrowse