ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0005262
Name calcium channel activity
Type molecular function
No. of Genes in ADHDgene  20
Source Pathway by PBA (with statistical significance of FDR<0.05)

PBA Result (with statistical significance of FDR<0.05)
Data Set Reference Gene Set Mapping Rule P-value FDR Result Link
Neale BM, 2008 MsigDB 3.0 c5.mf 5kb upstream and downstream of gene < 0.001 0.008 Link

Comments for this pathway (count: 3)
PMID Citation Comment
21130132 Mick E, McGough JJ, et al.Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder. Prog Neuro-Psychopharmacol Biol Psychiatry 2011, 35(2):466-472.
7976448 Sallee FR, Sethuraman G, Rock CM Effects of pimozide on cognition in children with Tourette syndrome: interaction with comorbid attention deficit hyperactivity disorder. Acta Psychiatr Scand 1994, 90(1):4-9. Pimozide,a L-type calcium channel blocker,has a significant ...... Pimozide,a L-type calcium channel blocker,has a significant impact on the patients with TS and ADHD More...
11772131 Jimenez-Jimenez FJ, Garcia-Ruiz PJ: Pharmacological options for the treatment of Tourette's disorder. Drugs 2001, 61(15):2207-2220. calcium channel antagonists is a potential usefulness drug f...... calcium channel antagonists is a potential usefulness drug for the patients suffering from the Tourette's disorder,which is associated with ADHD, More...

GO related genes in ADHDgene (count: 20)

Literature-origin genes (count: 3)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 10p12 1(1/0/0) NAS[9594024]
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 4(1/3/0) IEA
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 12p12 2(1/1/0) IEA

Genes from other sources Help (count: 17)

Approved Symbol Approved Name Source Evidence[PMID]
TRPM1 transient receptor potential cation channel, subfamily M, member 1 Mapped by CNV; Mapped by significant region; Mapped by PBA pathway TAS[9806836]
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 Mapped by significant region; Mapped by PBA pathway TAS[9169438]
RYR2 ryanodine receptor 2 (cardiac) Mapped by CNV; Mapped by PBA pathway ISS
TRPM2 transient receptor potential cation channel, subfamily M, member 2 Mapped by PBA pathway IEA
TRPC3 transient receptor potential cation channel, subfamily C, member 3 Mapped by PBA pathway TAS[9930701]
PANX1 pannexin 1 Mapped by significant region IMP[16908669]
TRPV5 transient receptor potential cation channel, subfamily V, member 5 Mapped by PBA pathway ISS
PDE2A phosphodiesterase 2A, cGMP-stimulated Mapped by significant region TAS[10375378]
TRPV2 transient receptor potential cation channel, subfamily V, member 2 Mapped by significant region IEA
CUL5 cullin 5 Mapped by significant region; Mapped by PBA pathway TAS[9581826]
TRPC5 transient receptor potential cation channel, subfamily C, member 5 Mapped by PBA pathway IDA
TRPV1 transient receptor potential cation channel, subfamily V, member 1 Mapped by PBA pathway IEA
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A Mapped by significant region IEA
TRPC1 transient receptor potential cation channel, subfamily C, member 1 Mapped by PBA pathway TAS[8646775]
RYR1 ryanodine receptor 1 (skeletal) Mapped by PBA pathway ISS
TRPV6 transient receptor potential cation channel, subfamily V, member 6 Mapped by PBA pathway IDA[15184369]
CATSPER2 cation channel, sperm associated 2 Mapped by LD-proxy IEA