ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0005262
Name calcium channel activity
Type molecular function
No. of Genes in ADHDgene  20
Source Pathway by PBA (with statistical significance of FDR<0.05)

PBA Result (with statistical significance of FDR<0.05)
Data Set Reference Gene Set Mapping Rule P-value FDR Result Link
Neale BM, 2008 MsigDB 3.0 c5.mf 5kb upstream and downstream of gene < 0.001 0.008 Link

Comments for this pathway (count: 3)
PMID Citation Comment
11772131 Jimenez-Jimenez FJ, Garcia-Ruiz PJ: Pharmacological options for the treatment of Tourette's disorder. Drugs 2001, 61(15):2207-2220. calcium channel antagonists is a potential usefulness drug f...... calcium channel antagonists is a potential usefulness drug for the patients suffering from the Tourette's disorder,which is associated with ADHD, More...
7976448 Sallee FR, Sethuraman G, Rock CM Effects of pimozide on cognition in children with Tourette syndrome: interaction with comorbid attention deficit hyperactivity disorder. Acta Psychiatr Scand 1994, 90(1):4-9. Pimozide,a L-type calcium channel blocker,has a significant ...... Pimozide,a L-type calcium channel blocker,has a significant impact on the patients with TS and ADHD More...
21130132 Mick E, McGough JJ, et al.Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder. Prog Neuro-Psychopharmacol Biol Psychiatry 2011, 35(2):466-472.

GO related genes in ADHDgene (count: 20)

Literature-origin genes (count: 3)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 10p12 1(1/0/0) NAS[9594024]
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 4(1/3/0) IEA
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 12p12 2(1/1/0) IEA

Genes from other sources Help (count: 17)

Approved Symbol Approved Name Source Evidence[PMID]
TRPM1 transient receptor potential cation channel, subfamily M, member 1 Mapped by CNV; Mapped by significant region; Mapped by PBA pathway TAS[9806836]
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 Mapped by significant region; Mapped by PBA pathway TAS[9169438]
RYR2 ryanodine receptor 2 (cardiac) Mapped by CNV; Mapped by PBA pathway ISS
TRPM2 transient receptor potential cation channel, subfamily M, member 2 Mapped by PBA pathway IEA
TRPC3 transient receptor potential cation channel, subfamily C, member 3 Mapped by PBA pathway TAS[9930701]
PANX1 pannexin 1 Mapped by significant region IMP[16908669]
TRPV5 transient receptor potential cation channel, subfamily V, member 5 Mapped by PBA pathway ISS
PDE2A phosphodiesterase 2A, cGMP-stimulated Mapped by significant region TAS[10375378]
TRPV2 transient receptor potential cation channel, subfamily V, member 2 Mapped by significant region IEA
CUL5 cullin 5 Mapped by significant region; Mapped by PBA pathway TAS[9581826]
TRPC5 transient receptor potential cation channel, subfamily C, member 5 Mapped by PBA pathway IDA
TRPV1 transient receptor potential cation channel, subfamily V, member 1 Mapped by PBA pathway IEA
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A Mapped by significant region IEA
TRPC1 transient receptor potential cation channel, subfamily C, member 1 Mapped by PBA pathway TAS[8646775]
RYR1 ryanodine receptor 1 (skeletal) Mapped by PBA pathway ISS
TRPV6 transient receptor potential cation channel, subfamily V, member 6 Mapped by PBA pathway IDA[15184369]
CATSPER2 cation channel, sperm associated 2 Mapped by LD-proxy IEA