ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0005262
Name calcium channel activity
Type Molecular Function
No. of Genes in ADHDgene  40
Source Pathway by PBA (with statistical significance of FDR<0.05)

PBA Result (with statistical significance of FDR<0.05)
Data Set Reference Gene Set Mapping Rule P-value FDR Result Link
Neale BM, 2008 MsigDB 3.0 c5.mf 5kb upstream and downstream of gene < 0.001 0.008 Link

Comments for this pathway (count: 3)
PMID Citation Comment
21130132 Mick E, McGough JJ, et al.Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder. Prog Neuro-Psychopharmacol Biol Psychiatry 2011, 35(2):466-472.
7976448 Sallee FR, Sethuraman G, Rock CM Effects of pimozide on cognition in children with Tourette syndrome: interaction with comorbid attention deficit hyperactivity disorder. Acta Psychiatr Scand 1994, 90(1):4-9. Pimozide,a L-type calcium channel blocker,has a significant ...... Pimozide,a L-type calcium channel blocker,has a significant impact on the patients with TS and ADHD More...
11772131 Jimenez-Jimenez FJ, Garcia-Ruiz PJ: Pharmacological options for the treatment of Tourette's disorder. Drugs 2001, 61(15):2207-2220. calcium channel antagonists is a potential usefulness drug f...... calcium channel antagonists is a potential usefulness drug for the patients suffering from the Tourette's disorder,which is associated with ADHD, More...

GO related genes in ADHDgene (count: 40)

Literature-origin genes (count: 3)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 12p12 1(1/0/0)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 1(0/1/0)
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 3(1/2/0)

Genes from other sources Help (count: 37)

Approved Symbol Approved Name Source Evidence[PMID]
TRPC1 transient receptor potential cation channel, subfamily C, member 1 Mapped by PBA pathway TAS[8646775]
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 Mapped by PBA pathway
TRPM2 transient receptor potential cation channel, subfamily M, member 2 Mapped by PBA pathway
CACNB2 calcium channel, voltage-dependent, beta 2 subunit Mapped by PBA pathway NAS[9594024]
PDE2A phosphodiesterase 2A, cGMP-stimulated Mapped by significant region TAS[10375378]
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 Mapped by PBA pathway
TRPM1 transient receptor potential cation channel, subfamily M, member 1 Mapped by CNV; Mapped by PBA pathway; Mapped by significant region TAS[9806836]
TRPV1 transient receptor potential cation channel, subfamily V, member 1 Mapped by PBA pathway
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit Mapped by PBA pathway
CUL5 cullin 5 Mapped by PBA pathway; Mapped by significant region TAS[9581826]
RYR2 ryanodine receptor 2 (cardiac) Mapped by CNV; Mapped by PBA pathway
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit Mapped by PBA pathway
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 Mapped by PBA pathway
TRPC5 transient receptor potential cation channel, subfamily C, member 5 Mapped by PBA pathway
CACNB3 calcium channel, voltage-dependent, beta 3 subunit Mapped by PBA pathway
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit Mapped by PBA pathway; Mapped by significant region
TRPV2 transient receptor potential cation channel, subfamily V, member 2 Mapped by significant region
RYR3 ryanodine receptor 3 Mapped by CNV; Mapped by PBA pathway
TRPC4 transient receptor potential cation channel, subfamily C, member 4 Mapped by PBA pathway
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit Mapped by LD-proxy; Mapped by PBA pathway; Mapped by literature SNP
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit Mapped by PBA pathway
PANX1 pannexin 1 Mapped by significant region IMP[16908669]
TRPV5 transient receptor potential cation channel, subfamily V, member 5 Mapped by PBA pathway
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 Mapped by PBA pathway
CACNB4 calcium channel, voltage-dependent, beta 4 subunit Mapped by PBA pathway
TRPV6 transient receptor potential cation channel, subfamily V, member 6 Mapped by PBA pathway IDA[15184369]
CACNB1 calcium channel, voltage-dependent, beta 1 subunit Mapped by PBA pathway
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit Mapped by PBA pathway
TRPC3 transient receptor potential cation channel, subfamily C, member 3 Mapped by PBA pathway TAS[9930701]
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A Mapped by significant region
ORAI1 ORAI calcium release-activated calcium modulator 1 Mapped by PBA pathway
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) Mapped by PBA pathway; Mapped by significant region TAS[9169438]
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 Mapped by PBA pathway
RYR1 ryanodine receptor 1 (skeletal) Mapped by PBA pathway
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit Mapped by PBA pathway
CATSPER2 cation channel, sperm associated 2 Mapped by LD-proxy
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Mapped by PBA pathway