ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CACNA1G
Symbol Alias	Cav3.1, NBR13
Approved Name	calcium channel, voltage-dependent, T type, alpha 1G subunit
Location	17q22
Position	chr17:48638429-48704835, +
External Links	HGNC: 1394 Entrez Gene: 8913 Ensembl: ENSG00000006283 UCSC: uc002irk.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005262	calcium channel activity	Molecular Function		40

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0002027	regulation of heart rate	Biological Process		5
GO:0005891	voltage-gated calcium channel complex	Cellular Component		19
GO:0007268	synaptic transmission	Biological Process		96
GO:0006810	transport	Biological Process	TAS[9495342]	62
GO:0008332	low voltage-gated calcium channel activity	Molecular Function		3
GO:0007411	axon guidance	Biological Process		65
GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	Biological Process		4
GO:0070509	calcium ion import	Biological Process		6
GO:0010045	response to nickel cation	Biological Process		1
GO:0042391	regulation of membrane potential	Biological Process		9
GO:0097110	scaffold protein binding	Molecular Function		6

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04930	Type II diabetes mellitus	14	Insulin resistance is strongly associated with type II diabe...... Insulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Serine/threonine phosphorylation, interaction with SOCS, regulation of the expression, modification of the cellular localization, and degradation represent the molecular mechanisms stimulated by them. Various kinases (ERK, JNK, IKKbeta, PKCzeta, PKCtheta and mTOR) are involved in this process. More...
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...

Genes shared at least 5 GO terms with CACNA1G (count: 5)

Gene Symbol	Pathway Count	Pathway List
CACNA1H	8	voltage-gated calcium channel complex; calcium channel activity; transport; low voltage-gated calcium channel activity; axon guidance; calcium ion import; regulation of membrane potential; scaffold protein binding;
CACNB2	6	voltage-gated calcium channel complex; calcium channel activity; synaptic transmission; transport; axon guidance; calcium ion import;
CACNA1E	5	regulation of heart rate; voltage-gated calcium channel complex; calcium channel activity; synaptic transmission; transport;
CACNB3	5	voltage-gated calcium channel complex; calcium channel activity; synaptic transmission; transport; axon guidance;
CACNB4	5	voltage-gated calcium channel complex; calcium channel activity; synaptic transmission; transport; axon guidance;

Genes shared at least 2 KEGG pathways with CACNA1G (count: 14)

Gene Symbol	Pathway Count	Pathway List
CACNA1A	3	Type II diabetes mellitus; Calcium signaling pathway; MAPK signaling pathway;
CACNA1B	3	Type II diabetes mellitus; Calcium signaling pathway; MAPK signaling pathway;
CACNA1C	3	Type II diabetes mellitus; Calcium signaling pathway; MAPK signaling pathway;
CACNA1D	3	Type II diabetes mellitus; Calcium signaling pathway; MAPK signaling pathway;
CACNA1E	3	Type II diabetes mellitus; Calcium signaling pathway; MAPK signaling pathway;
MAPK1	2	Type II diabetes mellitus; MAPK signaling pathway;
MAPK3	2	Type II diabetes mellitus; MAPK signaling pathway;
MAPK9	2	Type II diabetes mellitus; MAPK signaling pathway;
CACNA1F	2	Calcium signaling pathway; MAPK signaling pathway;
CACNA1H	2	Calcium signaling pathway; MAPK signaling pathway;
CACNA1I	2	Calcium signaling pathway; MAPK signaling pathway;
CACNA1S	2	Calcium signaling pathway; MAPK signaling pathway;
PPP3R2	2	Calcium signaling pathway; MAPK signaling pathway;
PRKCB	2	Calcium signaling pathway; MAPK signaling pathway;

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Region: chr17:48638429..48704835 View in gBrowse