ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PANX1
Symbol Alias	MRS1, UNQ2529, PX1
Approved Name	pannexin 1
Name Alias	innexin
Location	11q14-q21
Position	chr11:93862094-93915138, +
External Links	HGNC: 8599 Entrez Gene: 24145 Ensembl: ENSG00000110218 UCSC: uc001per.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 26)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005262	calcium channel activity	Molecular Function	IMP[16908669]	40

GO terms by database search (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0097110	scaffold protein binding	Molecular Function		6
GO:0055077	gap junction hemi-channel activity	Molecular Function	IDA[17715132]	3
GO:0005921	gap junction	Cellular Component		7
GO:0005886	plasma membrane	Cellular Component		772
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0005783	endoplasmic reticulum	Cellular Component	IDA[16908669]	100
GO:0005102	receptor binding	Molecular Function	IPI[17036048]	61
GO:0002931	response to ischemia	Biological Process		1
GO:0002020	protease binding	Molecular Function		13
GO:0033198	response to ATP	Biological Process		4
GO:0034214	protein hexamerization	Biological Process	IDA[17715132]	2
GO:0022840	leak channel activity	Molecular Function	IMP[16908669]	1
GO:0032059	bleb	Cellular Component	IDA[17036048]	1
GO:0007268	synaptic transmission	Biological Process		96
GO:0016021	integral to membrane	Cellular Component		845
GO:0006812	cation transport	Biological Process	IDA[17036048]	8
GO:0006816	calcium ion transport	Biological Process	IMP[16908669]	32
GO:0050718	positive regulation of interleukin-1 beta secretion	Biological Process	IDA[17036048]	5
GO:0051015	actin filament binding	Molecular Function		14
GO:0046982	protein heterodimerization activity	Molecular Function		68
GO:0050717	positive regulation of interleukin-1 alpha secretion	Biological Process		2
GO:0044325	ion channel binding	Molecular Function		15
GO:0045087	innate immune response	Biological Process		54
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	Biological Process		8
GO:0043234	protein complex	Cellular Component		45

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PANX1 (count: 7)

Gene Symbol	Pathway Count	Pathway List
PANX3	5	gap junction hemi-channel activity; gap junction; plasma membrane; protein hexamerization; integral to membrane;
ATP10A	5	plasma membrane; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; cation transport;
CORO1A	5	plasma membrane; calcium ion transport; actin filament binding; innate immune response; protein complex;
RYR2	5	plasma membrane; calcium channel activity; calcium ion transport; ion channel binding; protein complex;
SLC6A3	5	plasma membrane; receptor binding; protease binding; synaptic transmission; integral to membrane;
TRPC1	5	plasma membrane; calcium channel activity; calcium ion transport; ion channel binding; protein complex;
CASP1	5	response to ATP; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-1 alpha secretion; innate immune response; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway;

Genes shared at least 2 KEGG pathways with PANX1 (count: 0)

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Region: chr11:93862094..93915138 View in gBrowse