ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CORO1A
Symbol Alias	HCORO1, p57, coronin-1
Approved Name	coronin, actin binding protein, 1A
Previous Name	coronin, actin-binding protein, 1A
Name Alias	Clabp TACO
Location	16p11.2
Position	chr16:30194731-30200397, +
External Links	HGNC: 2252 Entrez Gene: 11151 UCSC: uc002dww.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 3)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_16	chr16:29563594-30367556 (NCBI Build 36.1 (hg18))	803963	16p11.2	Loss
CNV_Williams[2010]_34	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813248	16p11.2	Loss	De novo
CNV_Williams[2010]_39	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813247	16p11.2	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 36)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 36)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008022	protein C-terminus binding	Molecular Function	IPI[9365277]	32
GO:0007015	actin filament organization	Biological Process		12
GO:0006928	cellular component movement	Biological Process	NAS[17341475]	16
GO:0006909	phagocytosis	Biological Process	IMP[17442961]	5
GO:0006816	calcium ion transport	Biological Process		32
GO:0005886	plasma membrane	Cellular Component	IDA[17442961]	772
GO:0005884	actin filament	Cellular Component	IDA[15800061]	5
GO:0005737	cytoplasm	Cellular Component	IDA[17341475]	690
GO:0030833	regulation of actin filament polymerization	Biological Process		5
GO:0030670	phagocytic vesicle membrane	Cellular Component		8
GO:0030595	leukocyte chemotaxis	Biological Process		2
GO:0030335	positive regulation of cell migration	Biological Process		29
GO:0030036	actin cytoskeleton organization	Biological Process	IMP[17442961]	21
GO:0030027	lamellipodium	Cellular Component	IDA[17442961]	27
GO:0008360	regulation of cell shape	Biological Process		20
GO:0008092	cytoskeletal protein binding	Molecular Function		11
GO:0043029	T cell homeostasis	Biological Process		2
GO:0043234	protein complex	Cellular Component	IDA[11094157]	45
GO:0042102	positive regulation of T cell proliferation	Biological Process		11
GO:0042803	protein homodimerization activity	Molecular Function	IDA[15601263]	113
GO:0032796	uropod organization	Biological Process		1
GO:0034097	response to cytokine stimulus	Biological Process		9
GO:0030864	cortical actin cytoskeleton	Cellular Component	IDA[15800061]	5
GO:0031589	cell-substrate adhesion	Biological Process	IMP[17442961]	2
GO:0051126	negative regulation of actin nucleation	Biological Process	IDA[17442961]	1
GO:0050918	positive chemotaxis	Biological Process	IDA[17442961]	7
GO:0051015	actin filament binding	Molecular Function	IDA[15601263]	14
GO:0045335	phagocytic vesicle	Cellular Component	IDA[17442961]	4
GO:0048873	homeostasis of number of cells within a tissue	Biological Process		1
GO:0043548	phosphatidylinositol 3-kinase binding	Molecular Function	IDA[11094157]	2
GO:0045087	innate immune response	Biological Process	NAS[17341475]	54
GO:0001772	immunological synapse	Cellular Component		5
GO:0005634	nucleus	Cellular Component	IDA[17341475]	770
GO:0005515	protein binding	Molecular Function		910
GO:0001891	phagocytic cup	Cellular Component	IDA[17442961]	1
GO:0001845	phagolysosome assembly	Biological Process	IMP[12132654]	2

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05152	Tuberculosis	30	Tuberculosis, or TB, is an infectious disease caused by Myco...... Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection. More...
hsa04145	Phagosome	32	Phagocytosis is the process of taking in relatively large pa...... Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes. More...

Genes shared at least 5 GO terms with CORO1A (count: 36)

Gene Symbol	Pathway Count	Pathway List
NF2	8	plasma membrane; cytoplasm; actin cytoskeleton organization; lamellipodium; cytoskeletal protein binding; cortical actin cytoskeleton; nucleus; protein binding;
ADRA2A	7	cellular component movement; plasma membrane; cytoplasm; positive regulation of cell migration; actin cytoskeleton organization; protein homodimerization activity; protein binding;
VIL1	7	cytoplasm; positive regulation of cell migration; lamellipodium; regulation of cell shape; protein homodimerization activity; actin filament binding; protein binding;
GOPC	6	protein C-terminus binding; plasma membrane; cytoplasm; protein complex; protein homodimerization activity; protein binding;
CDC42EP2	6	actin filament organization; plasma membrane; cytoplasm; actin cytoskeleton organization; regulation of cell shape; protein binding;
CFL1	6	actin filament organization; cytoplasm; actin cytoskeleton organization; cortical actin cytoskeleton; nucleus; protein binding;
NCK1	6	actin filament organization; plasma membrane; cytoplasm; positive regulation of T cell proliferation; nucleus; protein binding;
ARPC5	6	cellular component movement; cytoplasm; regulation of actin filament polymerization; actin cytoskeleton organization; lamellipodium; protein binding;
APC	6	plasma membrane; cytoplasm; positive regulation of cell migration; lamellipodium; nucleus; protein binding;
ILK	6	plasma membrane; cytoplasm; positive regulation of cell migration; lamellipodium; protein complex; protein binding;
MALT1	6	plasma membrane; cytoplasm; protein complex; innate immune response; nucleus; protein binding;
MAPK1	6	cytoplasm; positive regulation of cell migration; protein complex; innate immune response; nucleus; protein binding;
VEGFA	6	cytoplasm; positive regulation of cell migration; regulation of cell shape; protein homodimerization activity; positive chemotaxis; protein binding;
AKAP7	5	protein C-terminus binding; plasma membrane; protein complex; nucleus; protein binding;
BAIAP2	5	protein C-terminus binding; plasma membrane; cytoplasm; nucleus; protein binding;
TJP1	5	protein C-terminus binding; plasma membrane; cytoplasm; nucleus; protein binding;
BCAR1	5	actin filament organization; plasma membrane; cytoplasm; positive regulation of cell migration; protein binding;
INPPL1	5	actin filament organization; plasma membrane; cytoplasm; lamellipodium; protein binding;
ARFIP2	5	cellular component movement; plasma membrane; cytoplasm; actin cytoskeleton organization; protein binding;
WASL	5	cellular component movement; plasma membrane; lamellipodium; nucleus; protein binding;
PANX1	5	calcium ion transport; plasma membrane; protein complex; actin filament binding; innate immune response;
PRKCB	5	calcium ion transport; plasma membrane; cytoplasm; nucleus; protein binding;
APBB1	5	plasma membrane; cytoplasm; lamellipodium; nucleus; protein binding;
CRYAB	5	plasma membrane; cytoplasm; protein homodimerization activity; nucleus; protein binding;
CTNND1	5	plasma membrane; cytoplasm; lamellipodium; nucleus; protein binding;
PDE2A	5	plasma membrane; cytoplasm; protein homodimerization activity; nucleus; protein binding;
PRKD1	5	plasma membrane; cytoplasm; innate immune response; nucleus; protein binding;
RNF40	5	plasma membrane; cytoplasm; protein homodimerization activity; nucleus; protein binding;
STRN3	5	plasma membrane; cytoplasm; protein complex; nucleus; protein binding;
TSC1	5	actin filament; cytoplasm; lamellipodium; protein complex; protein binding;
HES1	5	cytoplasm; positive regulation of T cell proliferation; protein homodimerization activity; nucleus; protein binding;
PAFAH1B1	5	cytoplasm; actin cytoskeleton organization; protein homodimerization activity; nucleus; protein binding;
PYCARD	5	cytoplasm; protein homodimerization activity; innate immune response; nucleus; protein binding;
TFAP2A	5	cytoplasm; positive regulation of cell migration; protein homodimerization activity; nucleus; protein binding;
TRIM32	5	cytoplasm; positive regulation of cell migration; innate immune response; nucleus; protein binding;
TRIM5	5	cytoplasm; protein homodimerization activity; innate immune response; nucleus; protein binding;

Genes shared at least 2 KEGG pathways with CORO1A (count: 11)

Gene Symbol	Pathway Count	Pathway List
ATP6V0A2	2	Tuberculosis; Phagosome;
ATP6V0D2	2	Tuberculosis; Phagosome;
FCGR2A	2	Tuberculosis; Phagosome;
FCGR2B	2	Tuberculosis; Phagosome;
FCGR2C	2	Tuberculosis; Phagosome;
FCGR3A	2	Tuberculosis; Phagosome;
FCGR3B	2	Tuberculosis; Phagosome;
HLA-DRB1	2	Tuberculosis; Phagosome;
PIK3C3	2	Tuberculosis; Phagosome;
TCIRG1	2	Tuberculosis; Phagosome;
TLR4	2	Tuberculosis; Phagosome;

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Region: chr16:30194731..30200397 View in gBrowse