ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0046982
Name protein heterodimerization activity
Type molecular function
No. of Genes in ADHDgene  73
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 73)

Literature-origin genes (count: 17)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
H2AFY H2A histone family, member Y 5q31.1 1(0/1/0) IEA
ADRA2C adrenoceptor alpha 2C 4p16.3 7(2/4/1) IPI[16605244]
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 6p21.1-p12.3 1(0/0/1) IEA
TFEB transcription factor EB 6p21 1(0/0/1) IEA
ADRB1 adrenoceptor beta 1 10q25.3 2(0/2/0) IPI[12529373]
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 2q37 1(0/0/1) IPI
VEGFA vascular endothelial growth factor A 6p12 1(0/1/0) IDA[8702615]
ITGA1 integrin, alpha 1 5q11.1 2(0/2/0) IEA
ADRA1B adrenoceptor alpha 1B 5q33.3 2(1/1/0) IDA
NR4A2 nuclear receptor subfamily 4, group A, member 2 2q22-q23 2(0/2/0) IEA
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 6p12 1(1/0/0) IPI[11505339]
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 2p16.1 1(0/0/1) IPI[19616629]
STX1A syntaxin 1A (brain) 7q11.2 3(2/1/0) IEA
FOXP1 forkhead box P1 3p14.1 1(0/0/1) IBA
ADRA1A adrenoceptor alpha 1A 8p21.2 3(2/1/0) IDA
FOXP2 forkhead box P2 7q31 1(1/0/0) IBA
ADRA2A adrenoceptor alpha 2A 10q25.2 13(4/9/0) IPI[16605244]; ISS

Genes from other sources Help (count: 56)

Approved Symbol Approved Name Source Evidence[PMID]
CLCF1 cardiotrophin-like cytokine factor 1 Mapped by significant region IDA[10966616]
BCL2L11 BCL2-like 11 (apoptosis facilitator) Mapped by LD-proxy IEA
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa Mapped by significant region IEA
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) Mapped by significant region IEA
TPD52L1 tumor protein D52-like 1 Mapped by significant region IDA[9484778]
ERBB2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 Mapped by LD-proxy IDA[10572067]; IPI[7556068]; NAS[15504738]
TYR tyrosinase Mapped by significant region ISS
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) Mapped by significant region IMP[2123466]
SDCBP2 syndecan binding protein (syntenin) 2 Mapped by Literature SNP IPI[11152476]
POLA2 polymerase (DNA directed), alpha 2, accessory subunit Mapped by significant region IEA
SYT10 synaptotagmin X Mapped by CNV IEA
SMC2 structural maintenance of chromosomes 2 Mapped by significant region IPI[9789013]
INHA inhibin, alpha Mapped by significant region IEA
BDKRB2 bradykinin receptor B2 Mapped by PBA pathway IPI[10993080]
NEUROD2 neuronal differentiation 2 Mapped by LD-proxy ISS
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) Mapped by significant region IPI[1674604]
IKZF1 IKAROS family zinc finger 1 (Ikaros) Mapped by LD-proxy IEA
PANX1 pannexin 1 Mapped by significant region IEA
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 Mapped by LD-proxy IPI
ADCY2 adenylate cyclase 2 (brain) Mapped by significant region ISS
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) Mapped by significant region IEA
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 Mapped by CNV IDA[10381623]
TTR transthyretin Mapped by significant region IEA
SMC3 structural maintenance of chromosomes 3 Mapped by PBA pathway IPI[11590136]
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 Mapped by LD-proxy IPI
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) Mapped by significant region IEA
CENPW centromere protein W Mapped by significant region IEA
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 Mapped by LD-proxy IPI
KATNB1 katanin p80 (WD repeat containing) subunit B 1 Mapped by PBA pathway IPI[10751153]
H2AFX H2A histone family, member X Mapped by significant region IEA
CD3E CD3e molecule, epsilon (CD3-TCR complex) Mapped by significant region IPI[9485181]
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa Mapped by significant region IEA
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 Mapped by Literature SNP IPI
JAM3 junctional adhesion molecule 3 Mapped by significant region IEA
VEGFB vascular endothelial growth factor B Mapped by significant region IEA
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 Mapped by Literature SNP IPI
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 Mapped by LD-proxy IPI
ALG2 ALG2, alpha-1,3/1,6-mannosyltransferase Mapped by significant region IPI[11278427]
TSC2 tuberous sclerosis 2 Mapped by significant region IEA
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit Mapped by significant region IEA
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein Mapped by significant region IDA[19509286]
HNF1B HNF1 homeobox B Mapped by CNV IEA
UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 Mapped by LD-proxy IPI
FZD4 frizzled class receptor 4 Mapped by significant region IPI[14688793]
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa Mapped by CNV IEA
BARD1 BRCA1 associated RING domain 1 Mapped by significant region IPI[15265711]
CD3G CD3g molecule, gamma (CD3-TCR complex) Mapped by significant region IPI[9485181]
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated Mapped by significant region ISS
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 Mapped by significant region IPI[16870176]
CD3D CD3d molecule, delta (CD3-TCR complex) Mapped by significant region IPI[9485181]
CYBA cytochrome b-245, alpha polypeptide Mapped by significant region IPI[12042318]
ADORA2A adenosine A2a receptor Mapped by CNV IEA
KCNIP1 Kv channel interacting protein 1 Mapped by Literature SNP IEA
BAD BCL2-associated agonist of cell death Mapped by significant region IEA
NPAS4 neuronal PAS domain protein 4 Mapped by significant region IEA
SMC1A structural maintenance of chromosomes 1A Mapped by PBA pathway IPI[11590136]