ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0045087
Name innate immune response
Type biological process
No. of Genes in ADHDgene  57
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 57)

Literature-origin genes (count: 3)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
MAP2K3 mitogen-activated protein kinase kinase 3 17q11.2 1(0/1/0) TAS
PRKD1 protein kinase D1 14q11 1(0/1/0) IEA
TRIM32 tripartite motif containing 32 9q33.1 1(0/0/1) TAS[16175175]

Genes from other sources Help (count: 54)

Approved Symbol Approved Name Source Evidence[PMID]
NLRP10 NLR family, pyrin domain containing 10 Mapped by CNV IEA
MAP3K5 mitogen-activated protein kinase kinase kinase 5 Mapped by LD-proxy; Mapped by significant region IEA
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 Mapped by LD-proxy IEA
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 Mapped by significant region IEA
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A Mapped by significant region TAS
MAPK1 mitogen-activated protein kinase 1 Mapped by LD-proxy TAS
PYDC1 PYD (pyrin domain) containing 1 Mapped by CNV IDA[12656673]
CORO1A coronin, actin binding protein, 1A Mapped by CNV NAS[17341475]
UNC93B1 unc-93 homolog B1 (C. elegans) Mapped by significant region TAS
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) Mapped by CNV; Mapped by significant region IEA
C5 complement component 5 Mapped by significant region TAS
MEFV Mediterranean fever Mapped by significant region TAS
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa Mapped by significant region IEA
PANX1 pannexin 1 Mapped by significant region TAS
C9 complement component 9 Mapped by significant region TAS
MAPK7 mitogen-activated protein kinase 7 Mapped by significant region TAS
RNF125 ring finger protein 125, E3 ubiquitin protein ligase Mapped by significant region TAS
CASP1 caspase 1, apoptosis-related cysteine peptidase Mapped by significant region TAS
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein Mapped by significant region TAS
SYK spleen tyrosine kinase Mapped by significant region ISS
UBE2L6 ubiquitin-conjugating enzyme E2L 6 Mapped by significant region TAS
NCF2 neutrophil cytosolic factor 2 Mapped by significant region TAS[7938008]
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 Mapped by CNV TAS
PYCARD PYD and CARD domain containing Mapped by CNV TAS
COLEC12 collectin sub-family member 12 Mapped by CNV TAS[11564734]
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) Mapped by LD-proxy TAS
NLRX1 NLR family member X1 Mapped by significant region TAS
ATG5 autophagy related 5 Mapped by CNV TAS
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 Mapped by significant region IEA
TXN thioredoxin Mapped by significant region TAS
C7 complement component 7 Mapped by significant region TAS
DAK dihydroxyacetone kinase 2 homolog (S. cerevisiae) Mapped by significant region TAS
UBB ubiquitin B Mapped by significant region TAS
VNN1 vanin 1 Mapped by significant region ISS[14966568]
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 Mapped by significant region IEA
RIPK3 receptor-interacting serine-threonine kinase 3 Mapped by significant region TAS
MAPK9 mitogen-activated protein kinase 9 Mapped by CNV TAS
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Mapped by CNV TAS[17290298]
IRF7 interferon regulatory factor 7 Mapped by LD-proxy TAS
MAVS mitochondrial antiviral signaling protein Mapped by CNV IMP[19631370]; TAS
ATG9A autophagy related 9A Mapped by significant region IEA
TLR4 toll-like receptor 4 Mapped by significant region TAS[15356140]
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 Mapped by significant region TAS
CYBA cytochrome b-245, alpha polypeptide Mapped by significant region IMP[2243141]
MAPK3 mitogen-activated protein kinase 3 Mapped by CNV TAS
TRIM5 tripartite motif containing 5 Mapped by CNV IEA
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 Mapped by significant region TAS
C6 complement component 6 Mapped by significant region TAS
TLR9 toll-like receptor 9 Mapped by LD-proxy TAS[15356140]
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mapped by CNV IEA
CREBBP CREB binding protein Mapped by significant region TAS
UBC ubiquitin C Mapped by CNV TAS
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 Mapped by significant region TAS
FADD Fas (TNFRSF6)-associated via death domain Mapped by significant region TAS