ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MS4A2
Previous Symbol	FCER1B, IGER, APY
Symbol Alias	MS4A1
Approved Name	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
Previous Name	IgE responsiveness (atopic)
Location	11q12-q13
Position	chr11:59855734-59865940, +
External Links	HGNC: 7316 Entrez Gene: 2206 Ensembl: ENSG00000149534 UCSC: uc001nop.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005262	calcium channel activity	Molecular Function	TAS[9169438]	40

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0032998	Fc-epsilon receptor I complex	Cellular Component		1
GO:0042169	SH2 domain binding	Molecular Function		7
GO:0043306	positive regulation of mast cell degranulation	Biological Process		3
GO:0045121	membrane raft	Cellular Component		22
GO:0050663	cytokine secretion	Biological Process		1
GO:0051219	phosphoprotein binding	Molecular Function		4
GO:0051279	regulation of release of sequestered calcium ion into cytosol	Biological Process		1
GO:0070588	calcium ion transmembrane transport	Biological Process	TAS[9169438]	7
GO:0006954	inflammatory response	Biological Process		51
GO:0005887	integral to plasma membrane	Cellular Component		220
GO:0005768	endosome	Cellular Component		27
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	Biological Process		8
GO:0007202	activation of phospholipase C activity	Biological Process		12
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[9169438]	72
GO:0006959	humoral immune response	Biological Process	TAS[2448768]	4
GO:0019901	protein kinase binding	Molecular Function		51
GO:0019863	IgE binding	Molecular Function		1
GO:0009897	external side of plasma membrane	Cellular Component		34
GO:0008283	cell proliferation	Biological Process	TAS[2448768]	60

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05310	Asthma	3	Asthma is a complex syndrome with many clinical phenotypes i...... Asthma is a complex syndrome with many clinical phenotypes in both adults and children. Its major characteristics include a variable degree of airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Inhaled allergens encounter antigen presenting cells (APC) that line the airway. Upon recognition of the antigen and activation by APC, naive T cells differentiate into TH2 cells. Activated TH2 stimulate the formation of IgE by B cells. IgE molecules bind to IgE receptors located on mast cells. The crosslinking of mast-cell-bound IgE by allergens leads to the release of biologically active mediators (histamine, leukotrienes) by means of degranulation and, so, to the immediate symptoms of allergy. Mast cells also release chemotactic factors that contribute to the recruitment of inflammatory cells, particularly eosinophils, whose proliferation and differentiation from bone marrow progenitors is promoted by IL-5. The activation of eosinophils leads to release of toxic granules and oxygen free radicals that lead to tissue damage and promote the development of chronic inflammation. More...
hsa04664	Fc epsilon RI signaling pathway	20	Fc epsilon RI-mediated signaling pathways in mast cells are ...... Fc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation pathways are regulated both positively and negatively by the interactions of numerous signaling molecules. Mast cells that are thus activated release preformed granules which contain biogenic amines (especially histamines) and proteoglycans (especially heparin). The activation of phospholipase A2 causes the release of membrane lipids followed by development of lipid mediators such as leukotrienes (LTC4, LTD4 and LTE4) and prostaglandins (especially PDG2). There is also secretion of cytokines, the most important of which are TNF-alpha, IL-4 and IL-5. These mediators and cytokines contribute to inflammatory responses. More...

Genes shared at least 5 GO terms with MS4A2 (count: 2)

Gene Symbol	Pathway Count	Pathway List
CCR5	5	inflammatory response; integral to plasma membrane; endosome; G-protein coupled receptor signaling pathway; external side of plasma membrane;
EDNRA	5	integral to plasma membrane; protein kinase C-activating G-protein coupled receptor signaling pathway; activation of phospholipase C activity; G-protein coupled receptor signaling pathway; cell proliferation;

Genes shared at least 2 KEGG pathways with MS4A2 (count: 0)

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Region: chr11:59855734..59865940 View in gBrowse