ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TRPC3
Approved Name	transient receptor potential cation channel, subfamily C, member 3
Location	4q27
Position	chr4:122800182-122872909, -
External Links	HGNC: 12335 Entrez Gene: 7222 Ensembl: ENSG00000138741 UCSC: uc003ieg.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005262	calcium channel activity	Molecular Function	TAS[9930701]	40

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051592	response to calcium ion	Biological Process		9
GO:0070588	calcium ion transmembrane transport	Biological Process		7
GO:0030168	platelet activation	Biological Process		38
GO:0033198	response to ATP	Biological Process		4
GO:0070679	inositol 1,4,5 trisphosphate binding	Molecular Function	IDA[14505576]	5
GO:0005515	protein binding	Molecular Function	IPI[15757897]	910
GO:0007411	axon guidance	Biological Process		65
GO:0006816	calcium ion transport	Biological Process	TAS[9215637]	32
GO:0005887	integral to plasma membrane	Cellular Component	IDA[9368034]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0015279	store-operated calcium channel activity	Molecular Function	TAS[9215637]	7
GO:0010524	positive regulation of calcium ion transport into cytosol	Biological Process		3
GO:0007602	phototransduction	Biological Process	TAS[9215637]	6
GO:0007596	blood coagulation	Biological Process		83

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TRPC3 (count: 15)

Gene Symbol	Pathway Count	Pathway List
TRPC1	9	response to calcium ion; inositol 1,4,5 trisphosphate binding; protein binding; calcium channel activity; axon guidance; calcium ion transport; integral to plasma membrane; plasma membrane; store-operated calcium channel activity;
TRPC6	7	platelet activation; inositol 1,4,5 trisphosphate binding; protein binding; axon guidance; plasma membrane; store-operated calcium channel activity; blood coagulation;
TRPC4	7	inositol 1,4,5 trisphosphate binding; protein binding; calcium channel activity; axon guidance; calcium ion transport; plasma membrane; store-operated calcium channel activity;
TRPC5	7	inositol 1,4,5 trisphosphate binding; protein binding; calcium channel activity; axon guidance; calcium ion transport; integral to plasma membrane; store-operated calcium channel activity;
CACNA1D	5	calcium ion transmembrane transport; calcium channel activity; axon guidance; calcium ion transport; plasma membrane;
PDE2A	5	calcium ion transmembrane transport; protein binding; calcium channel activity; plasma membrane; blood coagulation;
ADRA2A	5	platelet activation; protein binding; integral to plasma membrane; plasma membrane; blood coagulation;
ADRA2B	5	platelet activation; protein binding; integral to plasma membrane; plasma membrane; blood coagulation;
ADRA2C	5	platelet activation; protein binding; integral to plasma membrane; plasma membrane; blood coagulation;
ARRB1	5	platelet activation; protein binding; plasma membrane; phototransduction; blood coagulation;
F2RL2	5	platelet activation; protein binding; integral to plasma membrane; plasma membrane; blood coagulation;
GP1BB	5	platelet activation; protein binding; integral to plasma membrane; plasma membrane; blood coagulation;
PRKCB	5	platelet activation; protein binding; calcium ion transport; plasma membrane; blood coagulation;
CACNB2	5	protein binding; calcium channel activity; axon guidance; calcium ion transport; integral to plasma membrane;
ORAI1	5	protein binding; calcium channel activity; integral to plasma membrane; store-operated calcium channel activity; blood coagulation;

Genes shared at least 2 KEGG pathways with TRPC3 (count: 0)

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Region: chr4:122800182..122872909 View in gBrowse