ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PDE2A
Approved Name	phosphodiesterase 2A, cGMP-stimulated
Location	11q13.1-q14.1
Position	chr11:72287185-72385773, -
External Links	HGNC: 8777 Entrez Gene: 5138 Ensembl: ENSG00000186642 UCSC: uc010rrc.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 43)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005262	calcium channel activity	Molecular Function	TAS[10375378]	40

GO terms by database search (count: 42)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0050729	positive regulation of inflammatory response	Biological Process		8
GO:0061028	establishment of endothelial barrier	Biological Process		2
GO:0070588	calcium ion transmembrane transport	Biological Process	TAS[10375378]	7
GO:0071260	cellular response to mechanical stimulus	Biological Process		14
GO:0071321	cellular response to cGMP	Biological Process	IDA[17704206]	2
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[17329248]	78
GO:0071560	cellular response to transforming growth factor beta stimulus	Biological Process	IEP[17704206]	9
GO:0004112	cyclic-nucleotide phosphodiesterase activity	Molecular Function	IDA[15938621]	1
GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	Biological Process	IDA[14687666]	1
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	Molecular Function	IDA[19689430]	1
GO:0006626	protein targeting to mitochondrion	Biological Process		7
GO:0030425	dendrite	Cellular Component		46
GO:0006198	cAMP catabolic process	Biological Process	IDA[17704206]; IMP[19252089]	3
GO:0030424	axon	Cellular Component		35
GO:0008144	drug binding	Molecular Function	IDA[15938621]; IPI[15938621]	19
GO:0030553	cGMP binding	Molecular Function	IDA[19689430]; IMP[15938621]	3
GO:0007596	blood coagulation	Biological Process		83
GO:0030552	cAMP binding	Molecular Function	IMP[15938621]	5
GO:0030911	TPR domain binding	Molecular Function	IPI[17329248]	1
GO:0019933	cAMP-mediated signaling	Biological Process	IMP[17704206]	3
GO:0008152	metabolic process	Biological Process	IDA[17329248]	10
GO:0030818	negative regulation of cAMP biosynthetic process	Biological Process		7
GO:0035690	cellular response to drug	Biological Process	IEP[14687666]; IMP[15938621]	8
GO:0030224	monocyte differentiation	Biological Process	IEP[14687666]	3
GO:0033159	negative regulation of protein import into nucleus, translocation	Biological Process	IDA[17329248]	1
GO:0019934	cGMP-mediated signaling	Biological Process	IMP[17704206]	2
GO:0042734	presynaptic membrane	Cellular Component		15
GO:0005634	nucleus	Cellular Component	IDA[10375378]	770
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus	Biological Process	IDA[14687666]	1
GO:0005515	protein binding	Molecular Function	IPI[17329248]	910
GO:0043116	negative regulation of vascular permeability	Biological Process	IMP[17704206]	4
GO:0005759	mitochondrial matrix	Cellular Component		32
GO:0042803	protein homodimerization activity	Molecular Function	IPI[19828435]	113
GO:0005737	cytoplasm	Cellular Component	IDA[10375378]	690
GO:0046069	cGMP catabolic process	Biological Process	IDA[19828435]	1
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0043117	positive regulation of vascular permeability	Biological Process	IMP[17704206]	4
GO:0005783	endoplasmic reticulum	Cellular Component		100
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA[10375378]	87
GO:0005886	plasma membrane	Cellular Component	IDA[19252089,17329248]	772
GO:0046872	metal ion binding	Molecular Function		170
GO:0005829	cytosol	Cellular Component	IDA[17329248]	447

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00230	Purine metabolism	22

Genes shared at least 5 GO terms with PDE2A (count: 107)

Gene Symbol	Pathway Count	Pathway List
ACHE	9	dendrite; axon; presynaptic membrane; nucleus; protein binding; protein homodimerization activity; Golgi apparatus; perinuclear region of cytoplasm; plasma membrane;
SNCA	8	axon; nucleus; protein binding; cytoplasm; Golgi apparatus; perinuclear region of cytoplasm; plasma membrane; cytosol;
CRYAB	8	nucleus; protein binding; protein homodimerization activity; cytoplasm; Golgi apparatus; plasma membrane; metal ion binding; cytosol;
STRN3	7	negative regulation of transcription from RNA polymerase II promoter; dendrite; nucleus; protein binding; cytoplasm; Golgi apparatus; plasma membrane;
VEGFA	7	negative regulation of transcription from RNA polymerase II promoter; blood coagulation; monocyte differentiation; protein binding; protein homodimerization activity; cytoplasm; positive regulation of vascular permeability;
WWOX	7	cellular response to transforming growth factor beta stimulus; nucleus; protein binding; cytoplasm; Golgi apparatus; plasma membrane; cytosol;
MTMR2	7	dendrite; axon; nucleus; protein binding; protein homodimerization activity; cytoplasm; cytosol;
PAK1	7	dendrite; axon; protein binding; cytoplasm; Golgi apparatus; plasma membrane; cytosol;
PRKG1	7	cGMP binding; blood coagulation; protein binding; cytoplasm; Golgi apparatus; plasma membrane; cytosol;
PARK2	7	nucleus; protein binding; cytoplasm; Golgi apparatus; endoplasmic reticulum; perinuclear region of cytoplasm; cytosol;
PRKD1	7	nucleus; protein binding; cytoplasm; Golgi apparatus; plasma membrane; metal ion binding; cytosol;
TLR4	6	positive regulation of inflammatory response; cellular response to mechanical stimulus; protein binding; cytoplasm; perinuclear region of cytoplasm; plasma membrane;
PDE4D	6	establishment of endothelial barrier; cAMP catabolic process; drug binding; cAMP binding; metal ion binding; cytosol;
CUL5	6	calcium ion transmembrane transport; calcium channel activity; nucleus; protein binding; plasma membrane; cytosol;
BNIP3	6	cellular response to mechanical stimulus; dendrite; nucleus; protein binding; protein homodimerization activity; cytoplasm;
HABP4	6	cellular response to mechanical stimulus; blood coagulation; nucleus; protein binding; cytoplasm; cytosol;
MAPK3	6	cellular response to mechanical stimulus; blood coagulation; nucleus; protein binding; Golgi apparatus; cytosol;
KAT5	6	negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; perinuclear region of cytoplasm; metal ion binding; cytosol;
TFAP2A	6	negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; protein homodimerization activity; cytoplasm; Golgi apparatus;
TXN	6	negative regulation of transcription from RNA polymerase II promoter; dendrite; axon; cellular response to drug; protein binding; cytosol;
CACNA1A	6	calcium channel activity; nucleus; protein binding; cytoplasm; plasma membrane; metal ion binding;
AIP	6	protein targeting to mitochondrion; nucleus; protein binding; cytoplasm; plasma membrane; cytosol;
TH	6	dendrite; cellular response to drug; nucleus; protein binding; cytoplasm; cytosol;
ADRA2A	6	blood coagulation; negative regulation of cAMP biosynthetic process; protein binding; protein homodimerization activity; cytoplasm; plasma membrane;
ARRB1	6	blood coagulation; nucleus; protein binding; cytoplasm; plasma membrane; cytosol;
ARRB2	6	blood coagulation; nucleus; protein binding; cytoplasm; plasma membrane; cytosol;
EHD3	6	blood coagulation; nucleus; protein binding; cytoplasm; perinuclear region of cytoplasm; plasma membrane;
MAPK1	6	blood coagulation; nucleus; protein binding; cytoplasm; Golgi apparatus; cytosol;
PRKAR2B	6	blood coagulation; cAMP binding; cytoplasm; perinuclear region of cytoplasm; plasma membrane; cytosol;
PRKCB	6	blood coagulation; nucleus; protein binding; cytoplasm; plasma membrane; cytosol;
STXBP3	6	blood coagulation; nucleus; protein binding; cytoplasm; plasma membrane; cytosol;
AIFM3	6	nucleus; cytoplasm; endoplasmic reticulum; plasma membrane; metal ion binding; cytosol;
CEP57	6	nucleus; protein binding; protein homodimerization activity; cytoplasm; Golgi apparatus; cytosol;
GSK3B	6	nucleus; protein binding; cytoplasm; perinuclear region of cytoplasm; plasma membrane; cytosol;
KARS	6	nucleus; mitochondrial matrix; cytoplasm; plasma membrane; metal ion binding; cytosol;
MALT1	6	nucleus; protein binding; cytoplasm; perinuclear region of cytoplasm; plasma membrane; cytosol;
NCK1	6	nucleus; protein binding; cytoplasm; endoplasmic reticulum; plasma membrane; cytosol;
PAFAH1B1	6	nucleus; protein binding; protein homodimerization activity; cytoplasm; perinuclear region of cytoplasm; cytosol;
PYCARD	6	nucleus; protein binding; protein homodimerization activity; cytoplasm; endoplasmic reticulum; cytosol;
TJP1	6	nucleus; protein binding; negative regulation of vascular permeability; cytoplasm; plasma membrane; cytosol;
TRPC3	5	calcium ion transmembrane transport; calcium channel activity; blood coagulation; protein binding; plasma membrane;
CYBA	5	cellular response to mechanical stimulus; dendrite; protein binding; Golgi apparatus; metal ion binding;
SLC6A4	5	cellular response to cGMP; protein binding; protein homodimerization activity; plasma membrane; cytosol;
CRYM	5	negative regulation of transcription from RNA polymerase II promoter; nucleus; protein homodimerization activity; cytoplasm; plasma membrane;
FLCN	5	negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; cytoplasm; plasma membrane;
HES1	5	negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; protein homodimerization activity; cytoplasm;
ID2	5	negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; cytoplasm; cytosol;
IRF7	5	negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; cytoplasm; cytosol;
MEN1	5	negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; cytoplasm; cytosol;
NEDD4L	5	negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; cytoplasm; cytosol;
PTCH1	5	negative regulation of transcription from RNA polymerase II promoter; protein binding; Golgi apparatus; perinuclear region of cytoplasm; plasma membrane;
USP2	5	negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; perinuclear region of cytoplasm; metal ion binding;
CACNA1C	5	calcium channel activity; protein binding; cytoplasm; plasma membrane; metal ion binding;
ADCY4	5	dendrite; protein binding; cytoplasm; plasma membrane; metal ion binding;
CADM1	5	dendrite; axon; protein binding; protein homodimerization activity; plasma membrane;
DRD2	5	dendrite; axon; drug binding; protein binding; plasma membrane;
EPHA5	5	dendrite; axon; cAMP-mediated signaling; perinuclear region of cytoplasm; plasma membrane;
FEZ1	5	dendrite; axon; protein binding; cytoplasm; plasma membrane;
GRM7	5	dendrite; axon; negative regulation of cAMP biosynthetic process; presynaptic membrane; plasma membrane;
MAP1S	5	dendrite; nucleus; protein binding; perinuclear region of cytoplasm; cytosol;
SORT1	5	dendrite; cytoplasm; Golgi apparatus; perinuclear region of cytoplasm; plasma membrane;
THY1	5	dendrite; protein binding; endoplasmic reticulum; plasma membrane; cytosol;
SLC6A3	5	axon; drug binding; protein binding; cytoplasm; plasma membrane;
ADRB1	5	drug binding; nucleus; protein binding; cytoplasm; plasma membrane;
ADORA2A	5	blood coagulation; presynaptic membrane; protein binding; negative regulation of vascular permeability; plasma membrane;
ADRA2C	5	blood coagulation; protein binding; protein homodimerization activity; cytoplasm; plasma membrane;
BCAR1	5	blood coagulation; protein binding; cytoplasm; plasma membrane; cytosol;
DGKH	5	blood coagulation; nucleus; cytoplasm; plasma membrane; metal ion binding;
NOS1	5	blood coagulation; protein binding; cytoplasm; perinuclear region of cytoplasm; cytosol;
PIK3CG	5	blood coagulation; protein binding; cytoplasm; plasma membrane; cytosol;
STX4	5	blood coagulation; protein binding; perinuclear region of cytoplasm; plasma membrane; cytosol;
YES1	5	blood coagulation; cytoplasm; Golgi apparatus; plasma membrane; cytosol;
FBP1	5	cellular response to drug; protein binding; cytoplasm; metal ion binding; cytosol;
PPM1F	5	cellular response to drug; protein binding; perinuclear region of cytoplasm; metal ion binding; cytosol;
PICALM	5	presynaptic membrane; nucleus; protein binding; Golgi apparatus; perinuclear region of cytoplasm;
ALKBH8	5	nucleus; protein binding; cytoplasm; metal ion binding; cytosol;
APC	5	nucleus; protein binding; cytoplasm; plasma membrane; cytosol;
ATXN2	5	nucleus; protein binding; cytoplasm; Golgi apparatus; perinuclear region of cytoplasm;
BAIAP2	5	nucleus; protein binding; cytoplasm; plasma membrane; cytosol;
CBL	5	nucleus; protein binding; cytoplasm; plasma membrane; cytosol;
COG3	5	nucleus; protein binding; cytoplasm; Golgi apparatus; plasma membrane;
CORO1A	5	nucleus; protein binding; protein homodimerization activity; cytoplasm; plasma membrane;
CRIPAK	5	nucleus; protein binding; cytoplasm; endoplasmic reticulum; plasma membrane;
CTNND1	5	nucleus; protein binding; cytoplasm; plasma membrane; cytosol;
DAXX	5	nucleus; protein binding; protein homodimerization activity; cytoplasm; cytosol;
HERC5	5	nucleus; protein binding; cytoplasm; perinuclear region of cytoplasm; cytosol;
KLHL20	5	nucleus; protein binding; cytoplasm; Golgi apparatus; perinuclear region of cytoplasm;
LPXN	5	nucleus; protein binding; cytoplasm; perinuclear region of cytoplasm; plasma membrane;
MAGI2	5	nucleus; protein binding; cytoplasm; perinuclear region of cytoplasm; plasma membrane;
NF2	5	nucleus; protein binding; cytoplasm; perinuclear region of cytoplasm; plasma membrane;
PPP1CA	5	nucleus; protein binding; cytoplasm; metal ion binding; cytosol;
PPP4C	5	nucleus; protein binding; cytoplasm; plasma membrane; metal ion binding;
PSMC3	5	nucleus; protein binding; cytoplasm; perinuclear region of cytoplasm; cytosol;
RNF40	5	nucleus; protein binding; protein homodimerization activity; cytoplasm; plasma membrane;
ROCK2	5	nucleus; protein binding; plasma membrane; metal ion binding; cytosol;
SART1	5	nucleus; protein binding; cytoplasm; Golgi apparatus; cytosol;
SMG1	5	nucleus; protein binding; cytoplasm; metal ion binding; cytosol;
SYTL2	5	nucleus; protein binding; cytoplasm; Golgi apparatus; plasma membrane;
TPPP	5	nucleus; protein binding; cytoplasm; perinuclear region of cytoplasm; plasma membrane;
TRIM5	5	nucleus; protein binding; protein homodimerization activity; cytoplasm; Golgi apparatus;
WWP1	5	nucleus; protein binding; cytoplasm; plasma membrane; cytosol;
CDK5RAP2	5	protein binding; cytoplasm; Golgi apparatus; perinuclear region of cytoplasm; cytosol;
CLASP2	5	protein binding; cytoplasm; Golgi apparatus; plasma membrane; cytosol;
GOPC	5	protein binding; protein homodimerization activity; cytoplasm; Golgi apparatus; plasma membrane;
INPPL1	5	protein binding; cytoplasm; Golgi apparatus; plasma membrane; cytosol;
CCDC88A	5	protein homodimerization activity; Golgi apparatus; endoplasmic reticulum; plasma membrane; cytosol;
CUBN	5	protein homodimerization activity; Golgi apparatus; endoplasmic reticulum; plasma membrane; cytosol;

Genes shared at least 2 KEGG pathways with PDE2A (count: 0)

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Region: chr11:72287185..72385773 View in gBrowse