ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PDE4D
Previous Symbol	DPDE3
Approved Name	phosphodiesterase 4D, cAMP-specific
Previous Name	phosphodiesterase 4D, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E3)
Name Alias	phosphodiesterase E3 dunce homolog (Drosophila)
Location	5q12
Position	chr5:58264865-59817947, -
External Links	HGNC: 8783 Entrez Gene: 5144 Ensembl: ENSG00000113448 UCSC: uc003jsa.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lesch[2011]_3	chr5:58263673-58339293 (NCBI Build 35 (hg17))	75620	5q11.2	Duplication	Maternal (affected)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	Molecular Function	NAS[10913353]	1
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity	Molecular Function	TAS[9371713]	2
GO:0005815	microtubule organizing center	Cellular Component		19
GO:0005829	cytosol	Cellular Component		447
GO:0006198	cAMP catabolic process	Biological Process	IMP[19252089]	3
GO:0006939	smooth muscle contraction	Biological Process		10
GO:0007165	signal transduction	Biological Process		171
GO:0007568	aging	Biological Process		29
GO:0008144	drug binding	Molecular Function	IPI[15938621]	19
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI[19372219]	23
GO:0030593	neutrophil chemotaxis	Biological Process		7
GO:0030552	cAMP binding	Molecular Function	IDA[15938621]	5
GO:0016020	membrane	Cellular Component		139
GO:0071222	cellular response to lipopolysaccharide	Biological Process		13
GO:0061028	establishment of endothelial barrier	Biological Process		2
GO:0046872	metal ion binding	Molecular Function		170
GO:0035264	multicellular organism growth	Biological Process		10
GO:0097110	scaffold protein binding	Molecular Function	IPI[19372219]	6

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00230	Purine metabolism	22

Genes shared at least 5 GO terms with PDE4D (count: 2)

Gene Symbol	Pathway Count	Pathway List
PDE2A	6	cytosol; cAMP catabolic process; drug binding; cAMP binding; establishment of endothelial barrier; metal ion binding;
PDE7B	5	3',5'-cyclic-AMP phosphodiesterase activity; cytosol; cAMP catabolic process; signal transduction; metal ion binding;

Genes shared at least 2 KEGG pathways with PDE4D (count: 0)

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Region: chr5:58264865..59817947 View in gBrowse