ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PICALM
Symbol Alias	CALM, CLTH
Approved Name	phosphatidylinositol binding clathrin assembly protein
Location	11q14
Position	chr11:85668485-85780924, -
External Links	HGNC: 15514 Entrez Gene: 8301 Ensembl: ENSG00000073921 UCSC: uc001pbm.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 26)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030097	hemopoiesis	Biological Process		8
GO:0030100	regulation of endocytosis	Biological Process	IMP[18182011]	3
GO:0016192	vesicle-mediated transport	Biological Process	TAS[8643484]	28
GO:0016197	endosomal transport	Biological Process	IMP[16262731]	11
GO:0030276	clathrin binding	Molecular Function	IDA[16262731]	4
GO:0031623	receptor internalization	Biological Process	IMP[14985334]	10
GO:0030122	AP-2 adaptor complex	Cellular Component	IDA[16262731]	1
GO:0030132	clathrin coat of coated pit	Cellular Component	IDA[10436022]	3
GO:0005634	nucleus	Cellular Component	IDA[16491119]	770
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005515	protein binding	Molecular Function	IPI[16491119]	910
GO:0005545	1-phosphatidylinositol binding	Molecular Function		6
GO:0006898	receptor-mediated endocytosis	Biological Process	IDA[10436022]	11
GO:0007409	axonogenesis	Biological Process		14
GO:0005905	coated pit	Cellular Component	IDA[10436022]	8
GO:0006461	protein complex assembly	Biological Process	TAS[8643484]	28
GO:0048813	dendrite morphogenesis	Biological Process		8
GO:0048471	perinuclear region of cytoplasm	Cellular Component		87
GO:0043231	intracellular membrane-bounded organelle	Cellular Component		62
GO:0042734	presynaptic membrane	Cellular Component		15
GO:0032880	regulation of protein localization	Biological Process	IDA[10436022]	5
GO:0032050	clathrin heavy chain binding	Molecular Function	IDA[10436022]	1
GO:0048268	clathrin coat assembly	Biological Process	IMP[16262731]	3
GO:0048261	negative regulation of receptor-mediated endocytosis	Biological Process	IDA[10436022]	4
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[11425879]	80
GO:0045211	postsynaptic membrane	Cellular Component		41

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PICALM (count: 7)

Gene Symbol	Pathway Count	Pathway List
ACHE	7	receptor internalization; nucleus; Golgi apparatus; protein binding; perinuclear region of cytoplasm; presynaptic membrane; postsynaptic membrane;
DAB2	6	clathrin coat of coated pit; nucleus; protein binding; coated pit; clathrin coat assembly; positive regulation of transcription, DNA-dependent;
ARRB2	5	receptor internalization; nucleus; protein binding; coated pit; postsynaptic membrane;
SNCA	5	receptor internalization; nucleus; Golgi apparatus; protein binding; perinuclear region of cytoplasm;
PDE2A	5	nucleus; Golgi apparatus; protein binding; perinuclear region of cytoplasm; presynaptic membrane;
TFAP2A	5	nucleus; Golgi apparatus; protein binding; intracellular membrane-bounded organelle; positive regulation of transcription, DNA-dependent;
PTCH1	5	Golgi apparatus; protein binding; perinuclear region of cytoplasm; intracellular membrane-bounded organelle; regulation of protein localization;

Genes shared at least 2 KEGG pathways with PICALM (count: 0)

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Region: chr11:85668485..85780924 View in gBrowse