ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	STRN3
Symbol Alias	SG2NA
Approved Name	striatin, calmodulin binding protein 3
Name Alias	cell cycle S/G2 nuclear autoantigen
Location	14q13-q21
Position	chr14:31363005-31495607, -
External Links	HGNC: 15720 Entrez Gene: 29966 Ensembl: ENSG00000196792 UCSC: uc001wqu.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
14q12	chr14:24600000-33300000	1 (1/0/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[11570823]	78
GO:0032403	protein complex binding	Molecular Function	IDA[18782753]	27
GO:0032355	response to estradiol stimulus	Biological Process		18
GO:0043025	neuronal cell body	Cellular Component		51
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	IDA[11570823]	132
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway	Biological Process		4
GO:0000159	protein phosphatase type 2A complex	Cellular Component	IDA[18782753]	5
GO:0005516	calmodulin binding	Molecular Function	NAS[10748158]	32
GO:0005794	Golgi apparatus	Cellular Component	IDA[11251078]	157
GO:0005515	protein binding	Molecular Function	IPI[18782753]	910
GO:0005737	cytoplasm	Cellular Component	IDA[18434427]	690
GO:0005654	nucleoplasm	Cellular Component	IDA[11570823]	183
GO:0030425	dendrite	Cellular Component		46
GO:0005634	nucleus	Cellular Component	IDA[18434427]	770
GO:0005886	plasma membrane	Cellular Component	IDA[11251078]	772
GO:0070016	armadillo repeat domain binding	Molecular Function	IPI[18502210]	1
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA[11570823]	64
GO:0043234	protein complex	Cellular Component		45
GO:0051721	protein phosphatase 2A binding	Molecular Function	IDA[18782753]	6
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[11570823]	131

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with STRN3 (count: 81)

Gene Symbol	Pathway Count	Pathway List
MEN1	8	negative regulation of transcription from RNA polymerase II promoter; protein binding; cytoplasm; nucleoplasm; nucleus; negative regulation of transcription, DNA-dependent; protein complex; positive regulation of transcription from RNA polymerase II promoter;
RBPJ	8	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; cytoplasm; nucleoplasm; nucleus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
RELA	8	protein complex binding; sequence-specific DNA binding transcription factor activity; protein binding; cytoplasm; nucleoplasm; nucleus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
FLCN	7	negative regulation of transcription from RNA polymerase II promoter; protein complex binding; protein binding; cytoplasm; nucleus; plasma membrane; positive regulation of transcription from RNA polymerase II promoter;
GATA6	7	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; nucleoplasm; nucleus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
HES1	7	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
HEY2	7	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
KDM1A	7	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; nucleoplasm; nucleus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
PDE2A	7	negative regulation of transcription from RNA polymerase II promoter; Golgi apparatus; protein binding; cytoplasm; dendrite; nucleus; plasma membrane;
SREBF1	7	negative regulation of transcription from RNA polymerase II promoter; protein complex binding; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; protein complex; positive regulation of transcription from RNA polymerase II promoter;
TFAP2A	7	negative regulation of transcription from RNA polymerase II promoter; Golgi apparatus; protein binding; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
GSK3B	7	neuronal cell body; protein binding; cytoplasm; nucleus; plasma membrane; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
ID2	6	negative regulation of transcription from RNA polymerase II promoter; protein binding; cytoplasm; nucleus; negative regulation of transcription, DNA-dependent; protein complex;
IRF7	6	negative regulation of transcription from RNA polymerase II promoter; protein binding; cytoplasm; nucleoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
ISL1	6	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; negative regulation of intracellular estrogen receptor signaling pathway; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
KAT5	6	negative regulation of transcription from RNA polymerase II promoter; protein complex binding; protein binding; nucleus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
NCOR1	6	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; cytoplasm; nucleoplasm; nucleus;
SNW1	6	negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleoplasm; nucleus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
CRYAB	6	response to estradiol stimulus; Golgi apparatus; protein binding; cytoplasm; nucleus; plasma membrane;
AATF	6	sequence-specific DNA binding transcription factor activity; Golgi apparatus; protein binding; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
MAPK1	6	Golgi apparatus; protein binding; cytoplasm; nucleoplasm; nucleus; protein complex;
PAK1	6	Golgi apparatus; protein binding; cytoplasm; dendrite; plasma membrane; protein complex;
PRKD1	6	Golgi apparatus; protein binding; cytoplasm; nucleus; plasma membrane; positive regulation of transcription from RNA polymerase II promoter;
WWOX	6	Golgi apparatus; protein binding; cytoplasm; nucleus; plasma membrane; positive regulation of transcription from RNA polymerase II promoter;
ATXN1	6	protein binding; cytoplasm; nucleoplasm; nucleus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
DAB2IP	5	negative regulation of transcription from RNA polymerase II promoter; cytoplasm; plasma membrane; protein phosphatase 2A binding; positive regulation of transcription from RNA polymerase II promoter;
FOXE1	5	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
HNF1B	5	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; positive regulation of transcription from RNA polymerase II promoter;
HOXA7	5	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
IKZF1	5	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
MAF	5	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
MED1	5	negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
MEIS2	5	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; positive regulation of transcription from RNA polymerase II promoter;
MTA2	5	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; positive regulation of transcription from RNA polymerase II promoter;
MYB	5	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
NEDD4L	5	negative regulation of transcription from RNA polymerase II promoter; protein binding; cytoplasm; nucleoplasm; nucleus;
PTCH1	5	negative regulation of transcription from RNA polymerase II promoter; protein complex binding; Golgi apparatus; protein binding; plasma membrane;
SPI1	5	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
TCF25	5	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; cytoplasm; nucleus;
TXN	5	negative regulation of transcription from RNA polymerase II promoter; neuronal cell body; protein binding; nucleoplasm; dendrite;
UBB	5	negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleoplasm; plasma membrane; positive regulation of transcription from RNA polymerase II promoter;
UBC	5	negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleoplasm; plasma membrane; positive regulation of transcription from RNA polymerase II promoter;
ARRB2	5	protein complex binding; protein binding; cytoplasm; nucleus; plasma membrane;
CDK5RAP2	5	protein complex binding; calmodulin binding; Golgi apparatus; protein binding; cytoplasm;
ERCC8	5	protein complex binding; protein binding; nucleoplasm; nucleus; protein complex;
PAFAH1B1	5	protein complex binding; neuronal cell body; protein binding; cytoplasm; nucleus;
RNF40	5	protein complex binding; protein binding; cytoplasm; nucleus; plasma membrane;
SLC6A3	5	protein complex binding; neuronal cell body; protein binding; cytoplasm; plasma membrane;
ETS1	5	response to estradiol stimulus; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; positive regulation of transcription from RNA polymerase II promoter;
GHR	5	response to estradiol stimulus; neuronal cell body; protein binding; nucleus; plasma membrane;
TH	5	response to estradiol stimulus; protein binding; cytoplasm; dendrite; nucleus;
CACNA1C	5	neuronal cell body; calmodulin binding; protein binding; cytoplasm; plasma membrane;
ILK	5	neuronal cell body; protein binding; cytoplasm; plasma membrane; protein complex;
SORT1	5	neuronal cell body; Golgi apparatus; cytoplasm; dendrite; plasma membrane;
UBXN1	5	neuronal cell body; protein binding; cytoplasm; dendrite; nucleus;
CBL	5	sequence-specific DNA binding transcription factor activity; protein binding; cytoplasm; nucleus; plasma membrane;
E2F5	5	sequence-specific DNA binding transcription factor activity; protein binding; cytoplasm; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter;
HINFP	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleoplasm; nucleus; negative regulation of transcription, DNA-dependent;
HMGA1	5	sequence-specific DNA binding transcription factor activity; protein binding; nucleoplasm; nucleus; negative regulation of transcription, DNA-dependent;
IRF9	5	sequence-specific DNA binding transcription factor activity; protein binding; cytoplasm; nucleoplasm; nucleus;
POU2F3	5	sequence-specific DNA binding transcription factor activity; protein binding; cytoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
TAF10	5	sequence-specific DNA binding transcription factor activity; protein binding; cytoplasm; nucleoplasm; nucleus;
CRIPAK	5	negative regulation of intracellular estrogen receptor signaling pathway; protein binding; cytoplasm; nucleus; plasma membrane;
TJP1	5	calmodulin binding; protein binding; cytoplasm; nucleus; plasma membrane;
ACHE	5	Golgi apparatus; protein binding; dendrite; nucleus; plasma membrane;
COG3	5	Golgi apparatus; protein binding; cytoplasm; nucleus; plasma membrane;
GOPC	5	Golgi apparatus; protein binding; cytoplasm; plasma membrane; protein complex;
MAPK3	5	Golgi apparatus; protein binding; nucleoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
SART1	5	Golgi apparatus; protein binding; cytoplasm; nucleoplasm; nucleus;
SNCA	5	Golgi apparatus; protein binding; cytoplasm; nucleus; plasma membrane;
SYTL2	5	Golgi apparatus; protein binding; cytoplasm; nucleus; plasma membrane;
ARRB1	5	protein binding; cytoplasm; nucleus; plasma membrane; positive regulation of transcription from RNA polymerase II promoter;
BNIP3	5	protein binding; cytoplasm; nucleoplasm; dendrite; nucleus;
CORO1A	5	protein binding; cytoplasm; nucleus; plasma membrane; protein complex;
MALT1	5	protein binding; cytoplasm; nucleus; plasma membrane; protein complex;
NCK1	5	protein binding; cytoplasm; nucleus; plasma membrane; positive regulation of transcription from RNA polymerase II promoter;
NR4A2	5	protein binding; cytoplasm; nucleoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
TP53BP1	5	protein binding; cytoplasm; nucleoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;
WWP1	5	protein binding; cytoplasm; nucleus; plasma membrane; negative regulation of transcription, DNA-dependent;
XRCC5	5	protein binding; cytoplasm; nucleoplasm; nucleus; negative regulation of transcription, DNA-dependent;
YAP1	5	protein binding; cytoplasm; nucleoplasm; nucleus; positive regulation of transcription from RNA polymerase II promoter;

Genes shared at least 2 KEGG pathways with STRN3 (count: 0)

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Region: chr14:31363005..31495607 View in gBrowse