ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DAB2IP
Symbol Alias	AF9Q34, DIP1/2, KIAA1743, AIP1
Approved Name	DAB2 interacting protein
Name Alias	nGAP-like protein, "DOC-2/DAB2 interactive protein", "ASK-interacting protein", "ASK1-interacting protein 1"
Location	9q33.1-q33.3
Position	chr9:124329336-124547809, +
External Links	HGNC: 17294 Entrez Gene: 153090 Ensembl: ENSG00000136848 UCSC: uc004bln.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q33	chr9:117700000-130300000	2 (1/1/0)

Gene related GO terms (count: 35)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 35)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0071356	cellular response to tumor necrosis factor	Biological Process	IDA[15310755]	9
GO:0071364	cellular response to epidermal growth factor stimulus	Biological Process	ISS[11812785]	3
GO:0071889	14-3-3 protein binding	Molecular Function	IDA[17389591]	3
GO:0071901	negative regulation of protein serine/threonine kinase activity	Biological Process		3
GO:0071902	positive regulation of protein serine/threonine kinase activity	Biological Process		4
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	Biological Process		14
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IDA[15310755]	5
GO:0043065	positive regulation of apoptotic process	Biological Process	IDA[12813029]	34
GO:0042803	protein homodimerization activity	Molecular Function	IPI[12813029]	113
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Biological Process	ISS[11812785]	6
GO:0035591	signaling adaptor activity	Molecular Function		1
GO:0035414	negative regulation of catenin import into nucleus	Biological Process		1
GO:0034261	negative regulation of Ras GTPase activity	Biological Process		1
GO:0032320	positive regulation of Ras GTPase activity	Biological Process		5
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Biological Process	ISS[18281285]	3
GO:0051721	protein phosphatase 2A binding	Molecular Function		6
GO:0050680	negative regulation of epithelial cell proliferation	Biological Process		5
GO:0048147	negative regulation of fibroblast proliferation	Biological Process		5
GO:0046580	negative regulation of Ras protein signal transduction	Biological Process		4
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[15310755]	131
GO:0043507	positive regulation of JUN kinase activity	Biological Process	IDA[15310755]	6
GO:0043407	negative regulation of MAP kinase activity	Biological Process	IDA[12813029]	7
GO:0005543	phospholipid binding	Molecular Function		61
GO:0005737	cytoplasm	Cellular Component		690
GO:0005099	Ras GTPase activator activity	Molecular Function		5
GO:0005123	death receptor binding	Molecular Function	IPI[15310755]	3
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[15310755]	78
GO:0031435	mitogen-activated protein kinase kinase kinase binding	Molecular Function	IPI[12813029]	7
GO:0032088	negative regulation of NF-kappaB transcription factor activity	Biological Process		10
GO:0019901	protein kinase binding	Molecular Function		51
GO:0031235	intrinsic to internal side of plasma membrane	Cellular Component		4
GO:0010633	negative regulation of epithelial cell migration	Biological Process		1
GO:0010719	negative regulation of epithelial to mesenchymal transition	Biological Process		1
GO:0005886	plasma membrane	Cellular Component	IDA[15310755]	772
GO:0007257	activation of JUN kinase activity	Biological Process	IDA[12813029]	8

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with DAB2IP (count: 10)

Gene Symbol	Pathway Count	Pathway List
PYCARD	7	cellular response to tumor necrosis factor; negative regulation of protein serine/threonine kinase activity; negative regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptotic process; protein homodimerization activity; cytoplasm; negative regulation of NF-kappaB transcription factor activity;
GSK3B	6	negative regulation of canonical Wnt receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of MAP kinase activity; cytoplasm; protein kinase binding; plasma membrane;
WNT11	6	negative regulation of canonical Wnt receptor signaling pathway; positive regulation of apoptotic process; positive regulation of Ras GTPase activity; cytoplasm; Ras GTPase activator activity; plasma membrane;
RASA1	6	positive regulation of Ras GTPase activity; negative regulation of Ras protein signal transduction; phospholipid binding; cytoplasm; Ras GTPase activator activity; intrinsic to internal side of plasma membrane;
SYNGAP1	6	positive regulation of Ras GTPase activity; negative regulation of Ras protein signal transduction; phospholipid binding; cytoplasm; Ras GTPase activator activity; intrinsic to internal side of plasma membrane;
APC	5	negative regulation of canonical Wnt receptor signaling pathway; positive regulation of apoptotic process; cytoplasm; protein kinase binding; plasma membrane;
FLCN	5	positive regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; plasma membrane;
MAP3K11	5	protein homodimerization activity; positive regulation of JUN kinase activity; cytoplasm; mitogen-activated protein kinase kinase kinase binding; activation of JUN kinase activity;
TFAP2A	5	protein homodimerization activity; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; negative regulation of transcription from RNA polymerase II promoter;
STRN3	5	protein phosphatase 2A binding; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; plasma membrane;

Genes shared at least 2 KEGG pathways with DAB2IP (count: 0)

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Region: chr9:124329336..124547809 View in gBrowse