ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SYNGAP1
Symbol Alias	SYNGAP, RASA5, KIAA1938
Approved Name	synaptic Ras GTPase activating protein 1
Previous Name	synaptic Ras GTPase activating protein 1 homolog (rat)
Location	6p21.3
Position	chr6:33387847-33421466, +
External Links	HGNC: 11497 Entrez Gene: 8831 Ensembl: ENSG00000197283 UCSC: uc011dri.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 0)

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs10807124	Chr6:33404064(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant	2(0/2/0)

rs_ID	Location	Functional Annotation
rs9394145	Chr6:33399778(Fwd)	intron_variant; missense_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 20)

ID	Name	Type	No. of Genes in ADHDgene
GO:0005097	Rab GTPase activator activity	Molecular Function	14
GO:0005099	Ras GTPase activator activity	Molecular Function	5
GO:0005543	phospholipid binding	Molecular Function	61
GO:0005737	cytoplasm	Cellular Component	690
GO:0017124	SH3 domain binding	Molecular Function	22
GO:0031235	intrinsic to internal side of plasma membrane	Cellular Component	4
GO:0032320	positive regulation of Ras GTPase activity	Biological Process	5
GO:0043066	negative regulation of apoptotic process	Biological Process	77
GO:0007265	Ras protein signal transduction	Biological Process	15
GO:0007389	pattern specification process	Biological Process	13
GO:0008542	visual learning	Biological Process	12
GO:0016358	dendrite development	Biological Process	9
GO:0043408	regulation of MAPK cascade	Biological Process	1
GO:0046580	negative regulation of Ras protein signal transduction	Biological Process	4
GO:0043113	receptor clustering	Biological Process	3
GO:0043198	dendritic shaft	Cellular Component	11
GO:0050771	negative regulation of axonogenesis	Biological Process	4
GO:0050803	regulation of synapse structure and activity	Biological Process	1
GO:0048167	regulation of synaptic plasticity	Biological Process	9
GO:0048169	regulation of long-term neuronal synaptic plasticity	Biological Process	4

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with SYNGAP1 (count: 2)

Gene Symbol	Pathway Count	Pathway List
DAB2IP	6	Ras GTPase activator activity; phospholipid binding; cytoplasm; intrinsic to internal side of plasma membrane; positive regulation of Ras GTPase activity; negative regulation of Ras protein signal transduction;
RASA1	6	Ras GTPase activator activity; phospholipid binding; cytoplasm; intrinsic to internal side of plasma membrane; positive regulation of Ras GTPase activity; negative regulation of Ras protein signal transduction;

Genes shared at least 2 KEGG pathways with SYNGAP1 (count: 0)

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Region: chr6:33387847..33421466 View in gBrowse