ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MYB
Symbol Alias	c-myb
Approved Name	v-myb myeloblastosis viral oncogene homolog (avian)
Previous Name	v-myb avian myeloblastosis viral oncogene homolog
Location	6q22-q23
Position	chr6:135502453-135540311, +
External Links	HGNC: 7545 Entrez Gene: 4602 Ensembl: ENSG00000118513 UCSC: uc003qfh.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
6q22-23	chr6:114600000-139000000	1 (1/0/0)

Gene related GO terms (count: 23)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0003682	chromatin binding	Molecular Function		48
GO:0006338	chromatin remodeling	Biological Process		10
GO:0005515	protein binding	Molecular Function		910
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process		26
GO:0003677	DNA binding	Molecular Function		220
GO:0001701	in utero embryonic development	Biological Process		32
GO:0048872	homeostasis of number of cells	Biological Process		4
GO:0051571	positive regulation of histone H3-K4 methylation	Biological Process		2
GO:0051574	positive regulation of histone H3-K9 methylation	Biological Process		1
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	NAS[2189102]	80
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0048538	thymus development	Biological Process		14
GO:0048566	embryonic digestive tract development	Biological Process		2
GO:0016363	nuclear matrix	Cellular Component	NAS[3014652]	16
GO:0030183	B cell differentiation	Biological Process		8
GO:0045624	positive regulation of T-helper cell differentiation	Biological Process		1
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process		64
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	NAS[2189102]	158
GO:0006816	calcium ion transport	Biological Process		32
GO:0007596	blood coagulation	Biological Process		83

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MYB (count: 53)

Gene Symbol	Pathway Count	Pathway List
HINFP	10	sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding; G1/S transition of mitotic cell cycle; DNA binding; in utero embryonic development; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
KDM1A	9	sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding; negative regulation of transcription from RNA polymerase II promoter; in utero embryonic development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; blood coagulation;
GATA6	8	sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding; negative regulation of transcription from RNA polymerase II promoter; in utero embryonic development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; blood coagulation;
MEN1	8	chromatin binding; chromatin remodeling; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; nuclear matrix; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent;
FOXE1	7	sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; DNA binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; thymus development; negative regulation of transcription, DNA-dependent;
HES1	7	sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; positive regulation of transcription from RNA polymerase II promoter; thymus development; negative regulation of transcription, DNA-dependent;
HMGA1	7	sequence-specific DNA binding transcription factor activity; protein binding; DNA binding; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
IKZF1	7	sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; DNA binding; positive regulation of transcription from RNA polymerase II promoter; thymus development; B cell differentiation; transcription, DNA-dependent;
RELA	7	sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding; DNA binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent;
SREBF1	7	sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
BARX2	6	sequence-specific DNA binding transcription factor activity; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
ETS1	6	sequence-specific DNA binding transcription factor activity; protein binding; DNA binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
HNF1B	6	sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
RBPJ	6	sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent;
SPI1	6	sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent;
TBX1	6	sequence-specific DNA binding transcription factor activity; DNA binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; thymus development; transcription, DNA-dependent;
TFAP2A	6	chromatin binding; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent;
ATXN1	6	protein binding; DNA binding; positive regulation of transcription from RNA polymerase II promoter; nuclear matrix; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent;
KAT5	6	protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent;
SNW1	6	protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of histone H3-K4 methylation; positive regulation of transcription from RNA polymerase II promoter; nuclear matrix; negative regulation of transcription, DNA-dependent;
CBFA2T3	5	sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
CREBZF	5	sequence-specific DNA binding transcription factor activity; protein binding; DNA binding; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent;
E2F5	5	sequence-specific DNA binding transcription factor activity; protein binding; DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
HEY2	5	sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent;
HOXA5	5	sequence-specific DNA binding transcription factor activity; protein binding; DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
HOXA7	5	sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent;
HOXB1	5	sequence-specific DNA binding transcription factor activity; DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
KLF4	5	sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent;
LMX1B	5	sequence-specific DNA binding transcription factor activity; protein binding; in utero embryonic development; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
MTA2	5	sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
NCOR1	5	sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
PHF5A	5	sequence-specific DNA binding transcription factor activity; DNA binding; positive regulation of transcription, DNA-dependent; nuclear matrix; transcription, DNA-dependent;
RCOR2	5	sequence-specific DNA binding transcription factor activity; chromatin binding; DNA binding; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent;
RREB1	5	sequence-specific DNA binding transcription factor activity; DNA binding; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent;
STRN3	5	sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent;
TCF25	5	sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; transcription, DNA-dependent;
ZNF24	5	sequence-specific DNA binding transcription factor activity; protein binding; DNA binding; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent;
ZNF263	5	sequence-specific DNA binding transcription factor activity; DNA binding; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
APBB1	5	chromatin binding; protein binding; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
MED1	5	chromatin binding; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
NCOR2	5	chromatin binding; protein binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; transcription, DNA-dependent;
PRKCB	5	chromatin binding; protein binding; transcription, DNA-dependent; calcium ion transport; blood coagulation;
FOXG1	5	protein binding; DNA binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent;
IRF7	5	protein binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
MAPK1	5	protein binding; DNA binding; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; blood coagulation;
NRIP1	5	protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
TGFBR1	5	protein binding; in utero embryonic development; positive regulation of transcription, DNA-dependent; thymus development; regulation of transcription, DNA-dependent;
UBB	5	protein binding; negative regulation of transcription from RNA polymerase II promoter; G1/S transition of mitotic cell cycle; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
UBC	5	protein binding; negative regulation of transcription from RNA polymerase II promoter; G1/S transition of mitotic cell cycle; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent;
VEGFA	5	protein binding; negative regulation of transcription from RNA polymerase II promoter; in utero embryonic development; positive regulation of transcription from RNA polymerase II promoter; blood coagulation;
ZBTB16	5	protein binding; DNA binding; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent;
ZNF423	5	protein binding; DNA binding; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent;
FOXF1	5	negative regulation of transcription from RNA polymerase II promoter; DNA binding; in utero embryonic development; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;

Genes shared at least 2 KEGG pathways with MYB (count: 0)

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Region: chr6:135502453..135540311 View in gBrowse