ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ARRB2
Previous Symbol	ARR2
Symbol Alias	BARR2, DKFZp686L0365
Approved Name	arrestin, beta 2
Name Alias	arrestin 3
Location	17p13
Position	chr17:4613784-4624795, +
External Links	HGNC: 712 Entrez Gene: 409 Ensembl: ENSG00000141480 UCSC: uc002fyj.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Brookes K, 2006	UNPHASED TDT P-value=0.00427, global P-value=0.0166, WHAP TDT P_sum P-value=0.317; OR=1.56, one or more SNPs with nominal P-value<0.05 located in this gene	Significant

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs7208257	Chr17:4620497(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1(1/0/0)

LD-proxies (count: 1)

rs_ID	Location	Functional Annotation
rs9905578	Chr17:4609640(Fwd)	downstream_gene_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 61)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 61)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005102	receptor binding	Molecular Function	IPI[18604210]	61
GO:0002092	positive regulation of receptor internalization	Biological Process		7
GO:0005634	nucleus	Cellular Component	IDA[16820410]	770
GO:0005515	protein binding	Molecular Function	IPI[19372219]	910
GO:0005829	cytosol	Cellular Component		447
GO:0005737	cytoplasm	Cellular Component	IDA[12958365]	690
GO:0005905	coated pit	Cellular Component		8
GO:0005886	plasma membrane	Cellular Component	IDA[18604210]	772
GO:0001664	G-protein coupled receptor binding	Molecular Function	IPI[10644702]	8
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin	Biological Process	IMP[12582207]	3
GO:0002031	G-protein coupled receptor internalization	Biological Process	IDA[10644702]; IMP[12582207]	6
GO:0016023	cytoplasmic membrane-bounded vesicle	Cellular Component		16
GO:0016323	basolateral plasma membrane	Cellular Component		29
GO:0016567	protein ubiquitination	Biological Process	IMP[15878855]	41
GO:0019904	protein domain specific binding	Molecular Function		40
GO:0030168	platelet activation	Biological Process		38
GO:0031397	negative regulation of protein ubiquitination	Biological Process	IDA[16378096]	5
GO:0031398	positive regulation of protein ubiquitination	Biological Process	IGI[19372219]	8
GO:0031410	cytoplasmic vesicle	Cellular Component	IDA[12958365]	20
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	IDA[16820410]	62
GO:0007179	transforming growth factor beta receptor signaling pathway	Biological Process	IDA[12958365]	14
GO:0007219	Notch signaling pathway	Biological Process		21
GO:0007420	brain development	Biological Process		33
GO:0007596	blood coagulation	Biological Process		83
GO:0007628	adult walking behavior	Biological Process		8
GO:0014069	postsynaptic density	Cellular Component		23
GO:0015031	protein transport	Biological Process		75
GO:0032720	negative regulation of tumor necrosis factor production	Biological Process		6
GO:0032715	negative regulation of interleukin-6 production	Biological Process		4
GO:0032695	negative regulation of interleukin-12 production	Biological Process		2
GO:0032691	negative regulation of interleukin-1 beta production	Biological Process		3
GO:0032403	protein complex binding	Molecular Function		27
GO:0032226	positive regulation of synaptic transmission, dopaminergic	Biological Process		1
GO:0032088	negative regulation of NF-kappaB transcription factor activity	Biological Process	IDA[16378096]	10
GO:0031826	type 2A serotonin receptor binding	Molecular Function		1
GO:0031762	follicle-stimulating hormone receptor binding	Molecular Function		1
GO:0031748	D1 dopamine receptor binding	Molecular Function		1
GO:0031702	type 1 angiotensin receptor binding	Molecular Function		2
GO:0031701	angiotensin receptor binding	Molecular Function	IPI[15611106]	2
GO:0031692	alpha-1B adrenergic receptor binding	Molecular Function		2
GO:0031691	alpha-1A adrenergic receptor binding	Molecular Function		1
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI[19372219]	23
GO:0031623	receptor internalization	Biological Process	IDA[12958365]	10
GO:0060326	cell chemotaxis	Biological Process	IMP[15635042]	2
GO:0060765	regulation of androgen receptor signaling pathway	Biological Process	IDA[19372219]	1
GO:0051897	positive regulation of protein kinase B signaling cascade	Biological Process		17
GO:0051928	positive regulation of calcium ion transport	Biological Process		6
GO:0050965	detection of temperature stimulus involved in sensory perception of pain	Biological Process		1
GO:0051019	mitogen-activated protein kinase binding	Molecular Function		4
GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	Biological Process	IMP[18604210]	1
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Biological Process		14
GO:0043422	protein kinase B binding	Molecular Function		3
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0042699	follicle-stimulating hormone signaling pathway	Biological Process		1
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IMP[15878855]	16
GO:0034260	negative regulation of GTPase activity	Biological Process		4
GO:0034392	negative regulation of smooth muscle cell apoptotic process	Biological Process		1
GO:0032947	protein complex scaffold	Molecular Function	IDA[19372219]	5
GO:0034122	negative regulation of toll-like receptor signaling pathway	Biological Process		1
GO:0071889	14-3-3 protein binding	Molecular Function		3
GO:0070374	positive regulation of ERK1 and ERK2 cascade	Biological Process	IDA[10644702]; IMP[12582207]	22

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04144	Endocytosis	39	Endocytosis is a mechanism for cells to remove ligands, nutr...... Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. More...
hsa04740	Olfactory transduction	173	Within the compact cilia of the olfactory receptor neurons (...... Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be transmitted to the brain. Odorant molecules bind to a receptor protein (R) coupled to an olfactory specific Gs-protein (G) and activate a type III adenylyl cyclase (AC), increasing intracellular cAMP levels. cAMP targets an olfactory-specific cyclic-nucleotide gated ion channel (CNG), allowing cations, particularly Na and Ca, to flow down their electrochemical gradients into the cell, depolarizing the ORN. Furthermore, the Ca entering the cell is able to activate a Ca-activated Cl channel, which would allow Cl to flow out of the cell, thus further increasing the depolarization. Elevated intracellular Ca causes adaptation by at least two different molecular steps: inhibition of the activity of adenylyl cyclase via CAMKII-dependent phosphorylation and down-regulation of the affinity of the CNG channel to cAMP.Longer exposure to odorants can stimulate particulate guanylyl cyclase in cilia to produce cGMP and activate PKG, leading to a further increase in amount and duration of intracellular cAMP levels, which may serve to convert inactive forms of protein kinase A (PKA2) to active forms (PKA*). As part of a feedback loop, PKA can inhibit the activation of particulate guanylyl cyclase. More...
hsa04062	Chemokine signaling pathway	32	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. More...
hsa04744	Phototransduction	3	Phototransduction is a biochemical process by which the phot...... Phototransduction is a biochemical process by which the photoreceptor cells generate electrical signals in response to captured photons. The vertebrate cascade starts with the absorption of photons by the photoreceptive pigments, the rhodopsins, which consist of a membrane embedded chromophore, 11-cis-retinal, and a G-protein-coupled receptor, opsin. The photon isomerizes 11-cis-retinal to all-trans-retinal which induces a structural change that activates the opsin. This triggers hydrolysis of cGMP by activating a transducinphosphodiesterase 6 (PDE6) cascade, which results in closure of the cGMP-gated cation channels (CNG) in the plasma membrane and membrane hyperpolarization. The hyperpolarization of the membrane potential of the photoreceptor cell modulates the release of neurotransmitters to downstream cells. Recovery from light involves the deactivation of the light- activated intermediates: photolyzed rhodopsin is phosphorylated by rhodopsin kinase (RK) and subsequently capped off by arrestin; GTP-binding transducin alpha subunit deactivates through a process that is stimulated by RGS9. More...
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...

Genes shared at least 5 GO terms with ARRB2 (count: 102)

Gene Symbol	Pathway Count	Pathway List
ARRB1	21	nucleus; protein binding; cytosol; cytoplasm; coated pit; plasma membrane; G-protein coupled receptor internalization; protein ubiquitination; platelet activation; negative regulation of protein ubiquitination; cytoplasmic vesicle; transcription from RNA polymerase II promoter; Notch signaling pathway; blood coagulation; protein transport; negative regulation of interleukin-6 production; negative regulation of NF-kappaB transcription factor activity; angiotensin receptor binding; ubiquitin protein ligase binding; proteasomal ubiquitin-dependent protein catabolic process; positive regulation of ERK1 and ERK2 cascade;
STXBP3	9	nucleus; protein binding; cytosol; cytoplasm; plasma membrane; basolateral plasma membrane; platelet activation; blood coagulation; protein transport;
TNFAIP3	9	nucleus; protein binding; cytosol; cytoplasm; negative regulation of protein ubiquitination; negative regulation of tumor necrosis factor production; negative regulation of interleukin-6 production; negative regulation of interleukin-1 beta production; negative regulation of NF-kappaB transcription factor activity;
CTNND1	7	receptor binding; nucleus; protein binding; cytosol; cytoplasm; plasma membrane; protein domain specific binding;
NCK1	7	receptor binding; nucleus; protein binding; cytosol; cytoplasm; plasma membrane; protein domain specific binding;
DRD2	7	positive regulation of receptor internalization; protein binding; plasma membrane; G-protein coupled receptor internalization; adult walking behavior; postsynaptic density; positive regulation of ERK1 and ERK2 cascade;
HSPA5	7	nucleus; protein binding; protein domain specific binding; platelet activation; positive regulation of protein ubiquitination; blood coagulation; ubiquitin protein ligase binding;
MALT1	7	nucleus; protein binding; cytosol; cytoplasm; plasma membrane; protein ubiquitination; positive regulation of protein ubiquitination;
PRKCB	7	nucleus; protein binding; cytosol; cytoplasm; plasma membrane; platelet activation; blood coagulation;
SNCA	7	nucleus; protein binding; cytosol; cytoplasm; plasma membrane; protein domain specific binding; receptor internalization;
TJP1	7	nucleus; protein binding; cytosol; cytoplasm; plasma membrane; basolateral plasma membrane; protein domain specific binding;
WWP1	7	nucleus; protein binding; cytosol; cytoplasm; plasma membrane; protein ubiquitination; proteasomal ubiquitin-dependent protein catabolic process;
ADRA2A	7	protein binding; cytoplasm; plasma membrane; basolateral plasma membrane; platelet activation; blood coagulation; alpha-1B adrenergic receptor binding;
BCAR1	7	protein binding; cytosol; cytoplasm; plasma membrane; platelet activation; blood coagulation; cell chemotaxis;
PIK3CG	7	protein binding; cytosol; cytoplasm; plasma membrane; platelet activation; blood coagulation; positive regulation of protein kinase B signaling cascade;
RCHY1	6	receptor binding; nucleus; protein binding; cytoplasm; protein ubiquitination; positive regulation of protein ubiquitination;
UFD1L	6	receptor binding; nucleus; protein binding; cytosol; protein complex binding; proteasomal ubiquitin-dependent protein catabolic process;
MAGI2	6	positive regulation of receptor internalization; nucleus; protein binding; cytoplasm; plasma membrane; postsynaptic density;
VEGFA	6	positive regulation of receptor internalization; protein binding; cytoplasm; platelet activation; blood coagulation; positive regulation of peptidyl-tyrosine phosphorylation;
AKAP7	6	nucleus; protein binding; cytosol; plasma membrane; protein domain specific binding; protein complex scaffold;
APOA1	6	nucleus; protein binding; plasma membrane; platelet activation; cytoplasmic vesicle; blood coagulation;
CBL	6	nucleus; protein binding; cytosol; cytoplasm; plasma membrane; protein ubiquitination;
CUL5	6	nucleus; protein binding; cytosol; plasma membrane; protein ubiquitination; ubiquitin protein ligase binding;
GSK3B	6	nucleus; protein binding; cytosol; cytoplasm; plasma membrane; ubiquitin protein ligase binding;
GSTP1	6	nucleus; protein binding; cytosol; cytoplasm; negative regulation of tumor necrosis factor production; negative regulation of interleukin-1 beta production;
HABP4	6	nucleus; protein binding; cytosol; cytoplasm; platelet activation; blood coagulation;
MAPK1	6	nucleus; protein binding; cytosol; cytoplasm; platelet activation; blood coagulation;
MAPK3	6	nucleus; protein binding; cytosol; platelet activation; blood coagulation; positive regulation of ERK1 and ERK2 cascade;
MEN1	6	nucleus; protein binding; cytosol; cytoplasm; transforming growth factor beta receptor signaling pathway; brain development;
NCOR1	6	nucleus; protein binding; cytoplasm; transcription from RNA polymerase II promoter; transforming growth factor beta receptor signaling pathway; Notch signaling pathway;
NEDD4L	6	nucleus; protein binding; cytosol; cytoplasm; protein ubiquitination; transforming growth factor beta receptor signaling pathway;
PDE2A	6	nucleus; protein binding; cytosol; cytoplasm; plasma membrane; blood coagulation;
PYCARD	6	nucleus; protein binding; cytosol; cytoplasm; negative regulation of NF-kappaB transcription factor activity; positive regulation of ERK1 and ERK2 cascade;
RELA	6	nucleus; protein binding; cytosol; cytoplasm; protein complex binding; ubiquitin protein ligase binding;
RNF40	6	nucleus; protein binding; cytoplasm; plasma membrane; protein complex binding; ubiquitin protein ligase binding;
TH	6	nucleus; protein binding; cytosol; cytoplasm; protein domain specific binding; cytoplasmic vesicle;
UBXN1	6	nucleus; protein binding; cytoplasm; negative regulation of protein ubiquitination; ubiquitin protein ligase binding; proteasomal ubiquitin-dependent protein catabolic process;
GOPC	6	protein binding; cytoplasm; plasma membrane; postsynaptic density; protein transport; postsynaptic membrane;
MC1R	6	protein binding; cytoplasm; plasma membrane; negative regulation of tumor necrosis factor production; ubiquitin protein ligase binding; positive regulation of protein kinase B signaling cascade;
STX4	6	protein binding; cytosol; plasma membrane; basolateral plasma membrane; platelet activation; blood coagulation;
SYK	6	protein binding; cytosol; plasma membrane; platelet activation; blood coagulation; positive regulation of peptidyl-tyrosine phosphorylation;
TLR4	6	protein binding; cytoplasm; plasma membrane; negative regulation of tumor necrosis factor production; negative regulation of interleukin-6 production; positive regulation of ERK1 and ERK2 cascade;
VEGFB	6	protein binding; platelet activation; blood coagulation; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of ERK1 and ERK2 cascade;
PRKAR2B	6	cytosol; cytoplasm; plasma membrane; protein domain specific binding; blood coagulation; ubiquitin protein ligase binding;
CADM1	5	receptor binding; protein binding; plasma membrane; basolateral plasma membrane; brain development;
FYB	5	receptor binding; nucleus; protein binding; cytosol; protein complex binding;
MIF	5	receptor binding; protein binding; cytoplasm; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of ERK1 and ERK2 cascade;
NTF3	5	receptor binding; positive regulation of receptor internalization; cytoplasmic membrane-bounded vesicle; brain development; positive regulation of peptidyl-tyrosine phosphorylation;
SLC6A3	5	receptor binding; protein binding; cytoplasm; plasma membrane; protein complex binding;
ACHE	5	nucleus; protein binding; plasma membrane; receptor internalization; postsynaptic membrane;
ADRB2	5	nucleus; protein binding; plasma membrane; desensitization of G-protein coupled receptor protein signaling pathway by arrestin; positive regulation of protein ubiquitination;
AIP	5	nucleus; protein binding; cytosol; cytoplasm; plasma membrane;
APC	5	nucleus; protein binding; cytosol; cytoplasm; plasma membrane;
BAIAP2	5	nucleus; protein binding; cytosol; cytoplasm; plasma membrane;
CFL1	5	nucleus; protein binding; cytoplasm; platelet activation; blood coagulation;
CRBN	5	nucleus; protein binding; cytoplasm; protein ubiquitination; proteasomal ubiquitin-dependent protein catabolic process;
CRYAB	5	nucleus; protein binding; cytosol; cytoplasm; plasma membrane;
DAXX	5	nucleus; protein binding; cytosol; cytoplasm; ubiquitin protein ligase binding;
DGKH	5	nucleus; cytoplasm; plasma membrane; platelet activation; blood coagulation;
EHD3	5	nucleus; protein binding; cytoplasm; plasma membrane; blood coagulation;
FLCN	5	nucleus; protein binding; cytoplasm; plasma membrane; protein complex binding;
FLT4	5	nucleus; protein binding; cytoplasm; plasma membrane; positive regulation of ERK1 and ERK2 cascade;
GHR	5	nucleus; protein binding; plasma membrane; receptor internalization; positive regulation of peptidyl-tyrosine phosphorylation;
HERC2	5	nucleus; protein binding; cytoplasm; protein ubiquitination; ubiquitin protein ligase binding;
IRF7	5	nucleus; protein binding; cytosol; cytoplasm; transcription from RNA polymerase II promoter;
IRF9	5	nucleus; protein binding; cytosol; cytoplasm; transcription from RNA polymerase II promoter;
KLHL20	5	nucleus; protein binding; cytoplasm; protein ubiquitination; proteasomal ubiquitin-dependent protein catabolic process;
MTMR2	5	nucleus; protein binding; cytosol; cytoplasm; postsynaptic density;
PAFAH1B1	5	nucleus; protein binding; cytosol; cytoplasm; protein complex binding;
PARK2	5	nucleus; protein binding; cytosol; cytoplasm; ubiquitin protein ligase binding;
PICALM	5	nucleus; protein binding; coated pit; receptor internalization; postsynaptic membrane;
PPP1CA	5	nucleus; protein binding; cytosol; cytoplasm; transforming growth factor beta receptor signaling pathway;
PRKD1	5	nucleus; protein binding; cytosol; cytoplasm; plasma membrane;
PTTG1	5	nucleus; protein binding; cytosol; cytoplasm; transcription from RNA polymerase II promoter;
RFWD2	5	nucleus; protein binding; cytosol; cytoplasm; protein ubiquitination;
RPS3	5	nucleus; protein binding; cytosol; cytoplasm; negative regulation of NF-kappaB transcription factor activity;
STRN3	5	nucleus; protein binding; cytoplasm; plasma membrane; protein complex binding;
UBE3A	5	nucleus; protein binding; cytosol; cytoplasm; brain development;
WASL	5	nucleus; protein binding; cytosol; plasma membrane; cytoplasmic membrane-bounded vesicle;
WWOX	5	nucleus; protein binding; cytosol; cytoplasm; plasma membrane;
ADORA2A	5	protein binding; plasma membrane; blood coagulation; postsynaptic density; postsynaptic membrane;
ADRA2C	5	protein binding; cytoplasm; plasma membrane; platelet activation; blood coagulation;
ADRBK1	5	protein binding; cytosol; cytoplasm; plasma membrane; receptor internalization;
ARHGAP32	5	protein binding; cytosol; plasma membrane; postsynaptic density; postsynaptic membrane;
CACNA1C	5	protein binding; cytoplasm; plasma membrane; adult walking behavior; postsynaptic density;
CDK5RAP2	5	protein binding; cytosol; cytoplasm; brain development; protein complex binding;
FZD4	5	protein binding; cytoplasm; plasma membrane; brain development; ubiquitin protein ligase binding;
GABARAPL2	5	protein binding; cytosol; cytoplasm; cytoplasmic vesicle; protein transport;
ILK	5	protein binding; cytosol; cytoplasm; plasma membrane; positive regulation of protein kinase B signaling cascade;
INPPL1	5	protein binding; cytosol; cytoplasm; plasma membrane; brain development;
PIK3R1	5	protein binding; cytosol; plasma membrane; platelet activation; blood coagulation;
PLCG2	5	protein binding; cytosol; plasma membrane; platelet activation; blood coagulation;
PRKG1	5	protein binding; cytosol; cytoplasm; plasma membrane; blood coagulation;
PTPRJ	5	protein binding; plasma membrane; blood coagulation; positive regulation of protein kinase B signaling cascade; mitogen-activated protein kinase binding;
RPTOR	5	protein binding; cytosol; cytoplasm; protein complex binding; 14-3-3 protein binding;
SHANK2	5	protein binding; cytoplasm; plasma membrane; postsynaptic density; postsynaptic membrane;
TRPC6	5	protein binding; plasma membrane; platelet activation; blood coagulation; positive regulation of calcium ion transport;
UBB	5	protein binding; cytosol; plasma membrane; transforming growth factor beta receptor signaling pathway; Notch signaling pathway;
UBC	5	protein binding; cytosol; plasma membrane; transforming growth factor beta receptor signaling pathway; Notch signaling pathway;
XPO1	5	protein binding; cytosol; cytoplasm; protein domain specific binding; transforming growth factor beta receptor signaling pathway;
CCDC88A	5	cytosol; plasma membrane; cytoplasmic membrane-bounded vesicle; cytoplasmic vesicle; protein kinase B binding;
LIN7C	5	basolateral plasma membrane; protein domain specific binding; postsynaptic density; protein transport; postsynaptic membrane;

Genes shared at least 2 KEGG pathways with ARRB2 (count: 16)

Gene Symbol	Pathway Count	Pathway List
ARRB1	4	Endocytosis; Chemokine signaling pathway; Phototransduction; MAPK signaling pathway;
ADRBK2	3	Endocytosis; Olfactory transduction; Chemokine signaling pathway;
ADRBK1	2	Endocytosis; Chemokine signaling pathway;
CCR5	2	Endocytosis; Chemokine signaling pathway;
CXCR1	2	Endocytosis; Chemokine signaling pathway;
CXCR2	2	Endocytosis; Chemokine signaling pathway;
HSPA6	2	Endocytosis; MAPK signaling pathway;
HSPA8	2	Endocytosis; MAPK signaling pathway;
TGFBR1	2	Endocytosis; MAPK signaling pathway;
CRKL	2	Chemokine signaling pathway; MAPK signaling pathway;
MAPK1	2	Chemokine signaling pathway; MAPK signaling pathway;
MAPK3	2	Chemokine signaling pathway; MAPK signaling pathway;
PAK1	2	Chemokine signaling pathway; MAPK signaling pathway;
PRKCB	2	Chemokine signaling pathway; MAPK signaling pathway;
RASGRP2	2	Chemokine signaling pathway; MAPK signaling pathway;
RELA	2	Chemokine signaling pathway; MAPK signaling pathway;

View in gBrowse

Region: chr17:4613784..4624795 View in gBrowse