ADHDgene Database

Gene Report

Basic Info

Approved Symbol	TRPC6
Symbol Alias	TRP6
Approved Name	transient receptor potential cation channel, subfamily C, member 6
Location	11q22.1
Position	chr11:101322295-101743293, -
External Links	HGNC: 12338 Entrez Gene: 7225 Ensembl: ENSG00000137672 UCSC: uc001pgk.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)
11q22	chr11:97200000-110400000	1 (1/0/0)

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005886	plasma membrane	Cellular Component	IDA[10998353]	772
GO:0006812	cation transport	Biological Process	TAS[9930701]	8
GO:0007204	elevation of cytosolic calcium ion concentration	Biological Process		20
GO:0007411	axon guidance	Biological Process		65
GO:0007596	blood coagulation	Biological Process		83
GO:0015279	store-operated calcium channel activity	Molecular Function		7
GO:0016021	integral to membrane	Cellular Component		845
GO:0030168	platelet activation	Biological Process		38
GO:0032414	positive regulation of ion transmembrane transporter activity	Biological Process	IDA[10998353]	1
GO:0036057	slit diaphragm	Cellular Component		2
GO:0051928	positive regulation of calcium ion transport	Biological Process	IDA[10998353]	6
GO:0070679	inositol 1,4,5 trisphosphate binding	Molecular Function	IDA[14505576]	5
GO:0005515	protein binding	Molecular Function	IPI[15757897]	910

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TRPC6 (count: 8)

Gene Symbol	Pathway Count	Pathway List
TRPC3	7	plasma membrane; axon guidance; blood coagulation; store-operated calcium channel activity; platelet activation; inositol 1,4,5 trisphosphate binding; protein binding;
ARRB2	5	plasma membrane; blood coagulation; platelet activation; positive regulation of calcium ion transport; protein binding;
CACNA1C	5	plasma membrane; elevation of cytosolic calcium ion concentration; axon guidance; integral to membrane; protein binding;
PIK3CG	5	plasma membrane; elevation of cytosolic calcium ion concentration; blood coagulation; platelet activation; protein binding;
STIM2	5	plasma membrane; store-operated calcium channel activity; integral to membrane; positive regulation of calcium ion transport; protein binding;
STX4	5	plasma membrane; blood coagulation; integral to membrane; platelet activation; protein binding;
TRPC1	5	plasma membrane; axon guidance; store-operated calcium channel activity; inositol 1,4,5 trisphosphate binding; protein binding;
TRPC4	5	plasma membrane; axon guidance; store-operated calcium channel activity; inositol 1,4,5 trisphosphate binding; protein binding;

Genes shared at least 2 KEGG pathways with TRPC6 (count: 0)

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Region: chr11:101322295..101743293 View in gBrowse