ADHDgene Database

Gene Report

Basic Info

Approved Symbol	LIN7C
Symbol Alias	MALS-3, Lin7c, LIN-7C, LIN-7-C, VELI3, FLJ11215
Approved Name	lin-7 homolog C (C. elegans)
Name Alias	LIN-7 protein 3
Location	11p14
Position	chr11:27515965-27528326, -
External Links	HGNC: 17789 Entrez Gene: 55327 Ensembl: ENSG00000148943 UCSC: uc001mrl.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lanktree M, 2008	haplotype C-T P-value=0.025, X²=5.00 in the family-based sample, P-value=0.0063, X²=7.47, OR=1.58 in the combined samples; haplotype A-T P-value=0.020, X²=5.46, OR=0.67 in the combined samples; allelic and haplotype association was found	Significant

Gene related SNPs (count: 7)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs3763965	Chr11:27528987(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)
rs10835188	Chr11:27523186(Fwd)	intron_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs12790913	Chr11:27511998(Fwd)	downstream_gene_variant
rs7104230	Chr11:27515109(Fwd)	downstream_gene_variant
rs6484311	Chr11:27531764(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs6484306	Chr11:27517670(Fwd)	3_prime_UTR_variant
rs6484308	Chr11:27521802(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0014069	postsynaptic density	Cellular Component		23
GO:0008092	cytoskeletal protein binding	Molecular Function	IPI[17987659]	11
GO:0007269	neurotransmitter secretion	Biological Process		18
GO:0006887	exocytosis	Biological Process		14
GO:0030165	PDZ domain binding	Molecular Function		13
GO:0019904	protein domain specific binding	Molecular Function	IPI[17237226]	40
GO:0016323	basolateral plasma membrane	Cellular Component		29
GO:0015031	protein transport	Biological Process		75
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0005923	tight junction	Cellular Component		15

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with LIN7C (count: 1)

Gene Symbol	Pathway Count	Pathway List
ARRB2	5	postsynaptic density; protein domain specific binding; basolateral plasma membrane; protein transport; postsynaptic membrane;

Genes shared at least 2 KEGG pathways with LIN7C (count: 0)

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Region: chr11:27515965..27528326 View in gBrowse