Gene Report
Basic Info
Approved Symbol |
CFL1
|
Previous Symbol |
CFL |
Approved Name |
cofilin 1 (non-muscle) |
Location |
11q13.1 |
Position |
chr11:65590493-65629497, - |
External Links |
HGNC: 1874
Entrez Gene: 1072
Ensembl: ENSG00000172757
UCSC: uc001ofs.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 26)
Gene related KEGG pathways (count: 3)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04360 |
Axon guidance |
25 |
Axon guidance represents a key stage in the formation of neu......
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
More...
|
hsa04666 |
Fc gamma R-mediated phagocytosis |
28 |
Phagocytosis plays an essential role in host-defense mechani......
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
More...
|
hsa04810 |
Regulation of actin cytoskeleton |
48 |
|
Genes shared at least 5 GO terms with CFL1 (count: 29)
Genes shared at least 2 KEGG pathways with CFL1 (count: 14)
View in gBrowse