ADHDgene Database

Gene Report

Basic Info

Approved Symbol	ARPC2
Symbol Alias	p34-Arc, ARC34
Approved Name	actin related protein 2/3 complex, subunit 2, 34kDa
Previous Name	"actin related protein 2/3 complex, subunit 2 (34 kD)"
Location	2q36.1
Position	chr2:219081817-219119079, 1
External Links	HGNC: 705 Entrez Gene: 10109 Ensembl: ENSG00000163466 UCSC: uc002vhd.4
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003779	actin binding	molecular function	IEA	48
GO:0031252	cell leading edge	cellular component	IEA	4
GO:0005515	protein binding	molecular function	IPI[17350576]	1015
GO:0035650	AP-1 adaptor complex binding	molecular function	IEA	1
GO:0030838	positive regulation of actin filament polymerization	biological process	IEA	10
GO:0005200	structural constituent of cytoskeleton	molecular function	TAS[9230079]	15
GO:0015629	actin cytoskeleton	cellular component	TAS[9230079]	30
GO:0019894	kinesin binding	molecular function	IEA	5
GO:0005925	focal adhesion	cellular component	IEA	26
GO:0005886	plasma membrane	cellular component	IEA	839
GO:0005885	Arp2/3 protein complex	cellular component	TAS[9230079]	2
GO:0006928	cellular component movement	biological process	TAS[9230079]	18
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0005794	Golgi apparatus	cellular component	IDA	174
GO:0005768	endosome	cellular component	IEA	29
GO:0071933	Arp2/3 complex binding	molecular function	IEA	1
GO:0042995	cell projection	cellular component	IEA	12
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	biological process	IEA	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04810	Regulation of actin cytoskeleton	49

Genes shared at least 5 GO terms with ARPC2 (count: 12)

Gene Symbol	Pathway Count	Pathway List
ARPC5	7	actin binding; protein binding; structural constituent of cytoskeleton; actin cytoskeleton; Arp2/3 protein complex; cellular component movement; cytoplasm;
SNCA	6	protein binding; actin cytoskeleton; kinesin binding; plasma membrane; cytoplasm; Golgi apparatus;
ARF6	6	protein binding; positive regulation of actin filament polymerization; plasma membrane; cellular component movement; Golgi apparatus; endosome;
RDX	5	actin binding; protein binding; focal adhesion; plasma membrane; cytoplasm;
FMN1	5	actin binding; positive regulation of actin filament polymerization; actin cytoskeleton; plasma membrane; cytoplasm;
CCR5	5	actin binding; protein binding; plasma membrane; cytoplasm; endosome;
KLHL20	5	actin binding; protein binding; actin cytoskeleton; cytoplasm; Golgi apparatus;
INPPL1	5	actin binding; protein binding; plasma membrane; cytoplasm; Golgi apparatus;
WASL	5	actin binding; protein binding; actin cytoskeleton; plasma membrane; cellular component movement;
ADAM17	5	protein binding; actin cytoskeleton; focal adhesion; plasma membrane; cytoplasm;
LPXN	5	protein binding; focal adhesion; plasma membrane; cytoplasm; cell projection;
PAK1	5	protein binding; focal adhesion; plasma membrane; cytoplasm; Golgi apparatus;

Genes shared at least 2 KEGG pathways with ARPC2 (count: 0)

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Region: chr2:219081817..219119079 View in gBrowse