ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ARF6
Approved Name	ADP-ribosylation factor 6
Location	14q21.3
Position	chr14:50359810-50361490, 1
External Links	HGNC: 659 Entrez Gene: 382 Ensembl: ENSG00000165527 UCSC: uc001wxg.4
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 32)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0055037	recycling endosome	cellular component	IEA	5
GO:0005769	early endosome	cellular component	IEA	27
GO:0060998	regulation of dendritic spine development	biological process	ISS	1
GO:0016020	membrane	cellular component	TAS[8702973]	155
GO:0007155	cell adhesion	biological process	TAS[10036235]	99
GO:0031996	thioesterase binding	molecular function	IPI[15509780]	3
GO:0001889	liver development	biological process	IEA	16
GO:0006928	cellular component movement	biological process	TAS[10036235]	18
GO:0005794	Golgi apparatus	cellular component	IEA	174
GO:0016192	vesicle-mediated transport	biological process	TAS[10913182]	33
GO:0005768	endosome	cellular component	IDA; TAS[10913182]	29
GO:0090004	positive regulation of establishment of protein localization to plasma membrane	biological process	ISS	5
GO:0007264	small GTPase mediated signal transduction	biological process	IEA	65
GO:0003924	GTPase activity	molecular function	TAS[1993656]	46
GO:0030838	positive regulation of actin filament polymerization	biological process	IMP[10036235]	10
GO:0090162	establishment of epithelial cell polarity	biological process	IEA	1
GO:0035020	regulation of Rac protein signal transduction	biological process	IDA[10036235]	1
GO:0031529	ruffle organization	biological process	IDA[10036235]	5
GO:0015031	protein transport	biological process	IEA	89
GO:0031527	filopodium membrane	cellular component	IDA[14978216]	3
GO:0005938	cell cortex	cellular component	IDA[10913182]	29
GO:0030866	cortical actin cytoskeleton organization	biological process	IMP[10913182]	3
GO:0010008	endosome membrane	cellular component	IEA	31
GO:0006184	GTP catabolic process	biological process	TAS[1993656]	24
GO:0034394	protein localization to cell surface	biological process	ISS	4
GO:0005525	GTP binding	molecular function	TAS[10913182]	64
GO:0005886	plasma membrane	cellular component	IDA[17398095]	839
GO:0001726	ruffle	cellular component	IDA[9312003]	16
GO:0006915	apoptotic process	biological process	IEA	127
GO:0005515	protein binding	molecular function	IPI[16415858]	1015
GO:0048261	negative regulation of receptor-mediated endocytosis	biological process	TAS[9312003]	4
GO:0051489	regulation of filopodium assembly	biological process	IDA[14978216]	2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ARF6 (count: 34)

Gene Symbol	Pathway Count	Pathway List
RAB14	10	recycling endosome; early endosome; vesicle-mediated transport; small GTPase mediated signal transduction; GTPase activity; protein transport; GTP catabolic process; GTP binding; plasma membrane; protein binding;
ARFIP2	8	cellular component movement; small GTPase mediated signal transduction; ruffle organization; cell cortex; GTP binding; plasma membrane; ruffle; protein binding;
RAB6A	7	membrane; Golgi apparatus; small GTPase mediated signal transduction; GTPase activity; GTP catabolic process; GTP binding; protein binding;
RAB30	6	membrane; small GTPase mediated signal transduction; GTPase activity; protein transport; GTP catabolic process; GTP binding;
ARHGAP5	6	membrane; cell adhesion; small GTPase mediated signal transduction; GTPase activity; GTP catabolic process; GTP binding;
ARPC2	6	cellular component movement; Golgi apparatus; endosome; positive regulation of actin filament polymerization; plasma membrane; protein binding;
RAB38	6	small GTPase mediated signal transduction; GTPase activity; protein transport; GTP catabolic process; GTP binding; plasma membrane;
RHOT2	6	small GTPase mediated signal transduction; GTPase activity; GTP binding; plasma membrane; apoptotic process; protein binding;
MAPK1	5	early endosome; Golgi apparatus; small GTPase mediated signal transduction; apoptotic process; protein binding;
MAPK3	5	early endosome; Golgi apparatus; small GTPase mediated signal transduction; apoptotic process; protein binding;
GJA1	5	early endosome; Golgi apparatus; plasma membrane; apoptotic process; protein binding;
CHMP1A	5	early endosome; vesicle-mediated transport; protein transport; endosome membrane; protein binding;
SORT1	5	early endosome; Golgi apparatus; endosome; endosome membrane; plasma membrane;
MSLN	5	membrane; cell adhesion; Golgi apparatus; plasma membrane; protein binding;
SYTL2	5	membrane; Golgi apparatus; vesicle-mediated transport; plasma membrane; protein binding;
RAB1B	5	membrane; Golgi apparatus; small GTPase mediated signal transduction; protein transport; GTP binding;
BIRC6	5	membrane; Golgi apparatus; endosome; apoptotic process; protein binding;
GOPC	5	membrane; Golgi apparatus; protein transport; plasma membrane; protein binding;
ACHE	5	membrane; cell adhesion; Golgi apparatus; plasma membrane; protein binding;
TNFRSF12A	5	cellular component movement; plasma membrane; ruffle; apoptotic process; protein binding;
PRKD1	5	Golgi apparatus; cell cortex; plasma membrane; apoptotic process; protein binding;
RAB27A	5	Golgi apparatus; small GTPase mediated signal transduction; GTPase activity; GTP binding; protein binding;
PAK1	5	Golgi apparatus; plasma membrane; ruffle; apoptotic process; protein binding;
ARL17B	5	Golgi apparatus; vesicle-mediated transport; small GTPase mediated signal transduction; protein transport; GTP binding;
RHOD	5	small GTPase mediated signal transduction; GTPase activity; GTP catabolic process; GTP binding; plasma membrane;
ARL2	5	small GTPase mediated signal transduction; GTPase activity; GTP catabolic process; GTP binding; protein binding;
RAB2A	5	small GTPase mediated signal transduction; GTPase activity; protein transport; GTP catabolic process; GTP binding;
RAB6C	5	small GTPase mediated signal transduction; GTPase activity; protein transport; GTP catabolic process; GTP binding;
ARHGAP32	5	small GTPase mediated signal transduction; cell cortex; endosome membrane; plasma membrane; protein binding;
EHD3	5	GTPase activity; endosome membrane; GTP binding; plasma membrane; protein binding;
OPA1	5	GTPase activity; GTP catabolic process; GTP binding; apoptotic process; protein binding;
EHD1	5	GTPase activity; endosome membrane; GTP binding; plasma membrane; protein binding;
SEPT5	5	GTPase activity; GTP catabolic process; GTP binding; plasma membrane; protein binding;
MYO10	5	filopodium membrane; cell cortex; plasma membrane; ruffle; regulation of filopodium assembly;

Genes shared at least 2 KEGG pathways with ARF6 (count: 0)

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Region: chr14:50359810..50361490 View in gBrowse