ADHDgene Database

Gene Report

Basic Info

Approved Symbol	RAB6A
Previous Symbol	RAB6
Approved Name	RAB6A, member RAS oncogene family
Location	11q13.3
Position	chr11:73386683-73472201, -
External Links	HGNC: 9786 Entrez Gene: 5870 Ensembl: ENSG00000175582 UCSC: uc001oue.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lesch[2011]_7	chr11:72900000-73400000 (NCBI Build 35 (hg17))	500000	11q13.4	Duplication	Maternal (affected, also in affected sibling)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000042	protein targeting to Golgi	Biological Process	IDA[18243103]	4
GO:0000139	Golgi membrane	Cellular Component		95
GO:0003924	GTPase activity	Molecular Function	IDA[18243103]	41
GO:0005515	protein binding	Molecular Function	IPI[18243103]	910
GO:0005829	cytosol	Cellular Component	IDA[12447383]	447
GO:0005802	trans-Golgi network	Cellular Component	IDA[12447383]	28
GO:0005794	Golgi apparatus	Cellular Component	IDA[15229288]	157
GO:0005525	GTP binding	Molecular Function	IDA[19141279]	53
GO:0016020	membrane	Cellular Component	IDA[12447383]	139
GO:0007264	small GTPase mediated signal transduction	Biological Process		58
GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	Biological Process	TAS[12447383]	16
GO:0006184	GTP catabolic process	Biological Process	IDA[18243103]; TAS[2501306]	22
GO:0034067	protein localization to Golgi apparatus	Biological Process	IDA[12447383]	3
GO:0031410	cytoplasmic vesicle	Cellular Component	IDA[12447383]	20
GO:0019904	protein domain specific binding	Molecular Function	IPI[12447383]	40
GO:0018125	peptidyl-cysteine methylation	Biological Process	IDA[11121396]	1
GO:0072385	minus-end-directed organelle transport along microtubule	Biological Process	TAS[12447383]	2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with RAB6A (count: 11)

Gene Symbol	Pathway Count	Pathway List
RAB14	7	Golgi membrane; GTPase activity; protein binding; cytosol; GTP binding; small GTPase mediated signal transduction; GTP catabolic process;
ARF6	7	GTPase activity; protein binding; Golgi apparatus; GTP binding; membrane; small GTPase mediated signal transduction; GTP catabolic process;
ARHGAP5	6	GTPase activity; cytosol; GTP binding; membrane; small GTPase mediated signal transduction; GTP catabolic process;
RAB27A	6	GTPase activity; protein binding; Golgi apparatus; GTP binding; small GTPase mediated signal transduction; protein domain specific binding;
RAB30	6	GTPase activity; trans-Golgi network; GTP binding; membrane; small GTPase mediated signal transduction; GTP catabolic process;
COG7	5	Golgi membrane; protein binding; Golgi apparatus; retrograde vesicle-mediated transport, Golgi to ER; protein localization to Golgi apparatus;
GABARAPL2	5	Golgi membrane; protein binding; cytosol; Golgi apparatus; cytoplasmic vesicle;
RAB2A	5	Golgi membrane; GTPase activity; GTP binding; small GTPase mediated signal transduction; GTP catabolic process;
ARL2	5	GTPase activity; protein binding; GTP binding; small GTPase mediated signal transduction; GTP catabolic process;
RAN	5	GTPase activity; protein binding; cytosol; GTP binding; small GTPase mediated signal transduction;
RHOD	5	GTPase activity; cytosol; GTP binding; small GTPase mediated signal transduction; GTP catabolic process;

Genes shared at least 2 KEGG pathways with RAB6A (count: 0)

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Region: chr11:73386683..73472201 View in gBrowse