ADHDgene Database

Gene Report

Basic Info

Approved Symbol	RAB27A
Symbol Alias	RAB27, RAM, GS2, HsT18676
Approved Name	RAB27A, member RAS oncogene family
Location	15q15-q21.1
Position	chr15:55495164-55582001, -
External Links	HGNC: 9766 Entrez Gene: 5873 UCSC: uc002acq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation
rs7167572	Chr15:55574880(Fwd)	intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005764	lysosome	Cellular Component	IDA[15548590]	31
GO:0005770	late endosome	Cellular Component	IDA[17237785]	14
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0006605	protein targeting	Biological Process		5
GO:0001750	photoreceptor outer segment	Cellular Component		8
GO:0003924	GTPase activity	Molecular Function		41
GO:0005515	protein binding	Molecular Function	IPI[18812475]	910
GO:0005525	GTP binding	Molecular Function		53
GO:0019003	GDP binding	Molecular Function		6
GO:0019904	protein domain specific binding	Molecular Function		40
GO:0030318	melanocyte differentiation	Biological Process		4
GO:0030425	dendrite	Cellular Component	IDA[11266474]	46
GO:0006887	exocytosis	Biological Process	IDA[18812475]	14
GO:0007264	small GTPase mediated signal transduction	Biological Process		58
GO:0007596	blood coagulation	Biological Process		83
GO:0016324	apical plasma membrane	Cellular Component		51
GO:0045921	positive regulation of exocytosis	Biological Process	IMP[19966785]	5
GO:0043320	natural killer cell degranulation	Biological Process		1
GO:0043316	cytotoxic T cell degranulation	Biological Process		1
GO:0042470	melanosome	Cellular Component	IDA[11266474]	22
GO:0032585	multivesicular body membrane	Cellular Component	IDA[19966785]	2
GO:0032402	melanosome transport	Biological Process		1
GO:0031489	myosin V binding	Molecular Function		1
GO:0030667	secretory granule membrane	Cellular Component		5
GO:0071985	multivesicular body sorting pathway	Biological Process	IMP[19966785]	3
GO:0070382	exocytic vesicle	Cellular Component	IDA[18812475]	3

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with RAB27A (count: 11)

Gene Symbol	Pathway Count	Pathway List
RAB27B	9	GTPase activity; GTP binding; GDP binding; protein domain specific binding; small GTPase mediated signal transduction; apical plasma membrane; positive regulation of exocytosis; multivesicular body membrane; multivesicular body sorting pathway;
RAB14	7	lysosome; late endosome; GTPase activity; protein binding; GTP binding; GDP binding; small GTPase mediated signal transduction;
RAB6A	6	Golgi apparatus; GTPase activity; protein binding; GTP binding; protein domain specific binding; small GTPase mediated signal transduction;
MAPK1	5	late endosome; Golgi apparatus; protein binding; small GTPase mediated signal transduction; blood coagulation;
MAPK3	5	late endosome; Golgi apparatus; protein binding; small GTPase mediated signal transduction; blood coagulation;
ARF6	5	Golgi apparatus; GTPase activity; protein binding; GTP binding; small GTPase mediated signal transduction;
SYTL2	5	Golgi apparatus; protein binding; exocytosis; melanosome; exocytic vesicle;
MYO7A	5	photoreceptor outer segment; protein binding; protein domain specific binding; apical plasma membrane; melanosome;
ARL2	5	GTPase activity; protein binding; GTP binding; GDP binding; small GTPase mediated signal transduction;
RAB2A	5	GTPase activity; GTP binding; GDP binding; small GTPase mediated signal transduction; melanosome;
RAN	5	GTPase activity; protein binding; GTP binding; small GTPase mediated signal transduction; melanosome;

Genes shared at least 2 KEGG pathways with RAB27A (count: 0)

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Region: chr15:55495164..55582001 View in gBrowse