ADHDgene Database

Gene Report

Basic Info

Approved Symbol	RAB27B
Approved Name	RAB27B, member RAS oncogene family
Location	18q21.2
Position	chr18:52495708-52562747, +
External Links	HGNC: 9767 Entrez Gene: 5874 Ensembl: ENSG00000041353 UCSC: uc002lfr.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 0)

Gene related SNPs (count: 17)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2311120	Chr18:52477123(Fwd)	intron_variant	2(0/2/0)

rs_ID	Location	Functional Annotation
rs2008739	Chr18:52483302(Fwd)	intron_variant
rs2008315	Chr18:52484889(Fwd)	intron_variant
rs12604321	Chr18:52502759(Fwd)	intron_variant; nc_transcript_variant
rs1972593	Chr18:52505867(Fwd)	intron_variant; nc_transcript_variant
rs2018485	Chr18:52465668(Fwd)	intron_variant
rs9945718	Chr18:52491791(Fwd)	intron_variant; upstream_gene_variant
rs1819888	Chr18:52507270(Fwd)	intron_variant; nc_transcript_variant
rs1978355	Chr18:52515885(Fwd)	intron_variant; nc_transcript_variant
rs1833284	Chr18:52503589(Fwd)	intron_variant; nc_transcript_variant
rs2006776	Chr18:52504498(Fwd)	intron_variant; nc_transcript_variant
rs4800977	Chr18:52502887(Fwd)	intron_variant; nc_transcript_variant
rs1819887	Chr18:52503313(Fwd)	intron_variant; nc_transcript_variant
rs1833283	Chr18:52501562(Fwd)	intron_variant; nc_transcript_variant
rs4800976	Chr18:52502796(Fwd)	intron_variant; nc_transcript_variant
rs2016584	Chr18:52485773(Fwd)	intron_variant
rs9945547	Chr18:52491629(Fwd)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0071985	multivesicular body sorting pathway	Biological Process	IMP[19966785]	3
GO:0042589	zymogen granule membrane	Cellular Component		4
GO:0045921	positive regulation of exocytosis	Biological Process	IMP[19966785]	5
GO:0030140	trans-Golgi network transport vesicle	Cellular Component	IDA[19966785]	7
GO:0032585	multivesicular body membrane	Cellular Component	IDA[19966785]	2
GO:0019003	GDP binding	Molecular Function		6
GO:0019904	protein domain specific binding	Molecular Function	IPI[16880209]	40
GO:0016324	apical plasma membrane	Cellular Component		51
GO:0015031	protein transport	Biological Process		75
GO:0007264	small GTPase mediated signal transduction	Biological Process		58
GO:0005795	Golgi stack	Cellular Component	IDA[19966785]	9
GO:0005525	GTP binding	Molecular Function		53
GO:0003924	GTPase activity	Molecular Function		41

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04972	Pancreatic secretion	30	The pancreas performs both exocrine and endocrine functions....... The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion. More...

Genes shared at least 5 GO terms with RAB27B (count: 4)

Gene Symbol	Pathway Count	Pathway List
RAB27A	9	multivesicular body sorting pathway; positive regulation of exocytosis; multivesicular body membrane; GDP binding; protein domain specific binding; apical plasma membrane; small GTPase mediated signal transduction; GTP binding; GTPase activity;
RAB14	7	trans-Golgi network transport vesicle; GDP binding; protein transport; small GTPase mediated signal transduction; Golgi stack; GTP binding; GTPase activity;
RAB2A	5	GDP binding; protein transport; small GTPase mediated signal transduction; GTP binding; GTPase activity;
RAB30	5	protein transport; small GTPase mediated signal transduction; Golgi stack; GTP binding; GTPase activity;

Genes shared at least 2 KEGG pathways with RAB27B (count: 0)

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Region: chr18:52495708..52562747 View in gBrowse