ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04666
Name Fc gamma R-mediated phagocytosis
Description  Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
No. of Genes in ADHDgene  28
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 28)

Literature-origin genes (count: 1)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
DNM1 dynamin 1 9q34 1(0/0/1)

Genes from other sources Help(count: 27)

Approved Symbol Approved Name Location Source
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 11q13.1 Mapped by significant region
PRKCB protein kinase C, beta 16p12 Mapped by significant region
PLA2G4B phospholipase A2, group IVB (cytosolic) 15q11.2-q21.3 Mapped by PBA pathway
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 22q13.1 Mapped by PBA pathway
MAPK1 mitogen-activated protein kinase 1 22q11.2 Mapped by LD-proxy
PLD1 phospholipase D1, phosphatidylcholine-specific 3q26 Mapped by PBA pathway
SYK spleen tyrosine kinase 9q22 Mapped by significant region
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 22q11.21 Mapped by CNV
GSN gelsolin 9q33 Mapped by PBA pathway; Mapped by significant region
MAPK3 mitogen-activated protein kinase 3 16p11.2 Mapped by CNV
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 11q13-q14 Mapped by significant region
WASL Wiskott-Aldrich syndrome-like 7q31.3 Mapped by CNV
ARF6 ADP-ribosylation factor 6 14q21.3 Mapped by PBA pathway
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 2p24 Mapped by significant region
ARPC5L actin related protein 2/3 complex, subunit 5-like 9q34.11 Mapped by significant region
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa 1q Mapped by significant region
CFL1 cofilin 1 (non-muscle) 11q13.1 Mapped by significant region
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1q23 Mapped by CNV
PLD2 phospholipase D2 17p13.3 Mapped by PBA pathway
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 2q36.1 Mapped by significant region
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 5q13.1 Mapped by significant region
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1q23 Mapped by CNV
GAB2 GRB2-associated binding protein 2 11q13.4-q13.5 Mapped by significant region
PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide 7q22 Mapped by CNV
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) 1q23 Mapped by CNV
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1q23 Mapped by CNV
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 16q24.1 Mapped by significant region

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014