ADHDgene Database

Gene Report

Basic Info

Approved Symbol	RDX
Previous Symbol	DFNB24
Approved Name	radixin
Previous Name	"deafness, autosomal recessive 24"
Location	11q23
Position	chr11:110045605-110167447, -1
External Links	HGNC: 9944 Entrez Gene: 5962 Ensembl: ENSG00000137710 UCSC: uc031qdy.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)
11q22	chr11:97200000-110400000	1 (1/0/0)

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	molecular function	IPI	1015
GO:0003779	actin binding	molecular function	IEA	48
GO:0019898	extrinsic to membrane	cellular component	IEA	9
GO:0030033	microvillus assembly	biological process	IEA	1
GO:0030027	lamellipodium	cellular component	IEA	29
GO:0030175	filopodium	cellular component	IEA	6
GO:0045176	apical protein localization	biological process	IEA	4
GO:0001726	ruffle	cellular component	IEA	16
GO:0005856	cytoskeleton	cellular component	IEA	56
GO:0005925	focal adhesion	cellular component	IDA	26
GO:0005886	plasma membrane	cellular component	IDA	839
GO:0032420	stereocilium	cellular component	IEA	7
GO:0005737	cytoplasm	cellular component	IEA	781
GO:0032154	cleavage furrow	cellular component	IEA	10
GO:0051693	actin filament capping	biological process	IEA	3
GO:0045177	apical part of cell	cellular component	IEA	11

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04810	Regulation of actin cytoskeleton	49

Genes shared at least 5 GO terms with RDX (count: 12)

Gene Symbol	Pathway Count	Pathway List
NF2	7	protein binding; extrinsic to membrane; lamellipodium; cytoskeleton; plasma membrane; cytoplasm; cleavage furrow;
VIL1	6	protein binding; lamellipodium; filopodium; ruffle; cytoplasm; actin filament capping;
BCAR1	5	protein binding; ruffle; focal adhesion; plasma membrane; cytoplasm;
ILK	5	protein binding; lamellipodium; focal adhesion; plasma membrane; cytoplasm;
TNS1	5	protein binding; actin binding; cytoskeleton; focal adhesion; cytoplasm;
ARPC2	5	protein binding; actin binding; focal adhesion; plasma membrane; cytoplasm;
BAIAP2	5	protein binding; filopodium; ruffle; plasma membrane; cytoplasm;
INPPL1	5	protein binding; actin binding; lamellipodium; plasma membrane; cytoplasm;
FLNC	5	protein binding; actin binding; cytoskeleton; plasma membrane; cytoplasm;
PAK1	5	protein binding; ruffle; focal adhesion; plasma membrane; cytoplasm;
CTTN	5	protein binding; lamellipodium; ruffle; cytoskeleton; cytoplasm;
TWF2	5	lamellipodium; filopodium; cytoskeleton; stereocilium; cytoplasm;

Genes shared at least 2 KEGG pathways with RDX (count: 0)

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Region: chr11:110045605..110167447 View in gBrowse