ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	LPXN
Symbol Alias	LDPL
Approved Name	leupaxin
Location	11q12.1
Position	chr11:58294344-58345693, -1
External Links	HGNC: 14061 Entrez Gene: 9404 Ensembl: ENSG00000110031 UCSC: uc001nmw.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005634	nucleus	cellular component	IDA[18451096]	877
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA	99
GO:0007162	negative regulation of cell adhesion	biological process	IDA	7
GO:0005515	protein binding	molecular function	IPI	1015
GO:0050859	negative regulation of B cell receptor signaling pathway	biological process	IDA[17640867]	1
GO:0005925	focal adhesion	cellular component	IDA	26
GO:0007155	cell adhesion	biological process	IEA	99
GO:0006461	protein complex assembly	biological process	TAS[9565592]	32
GO:0006351	transcription, DNA-dependent	biological process	IEA	281
GO:0006355	regulation of transcription, DNA-dependent	biological process	IEA	182
GO:0002102	podosome	cellular component	IDA[12674328]	3
GO:0007165	signal transduction	biological process	TAS[9565592]	189
GO:0042995	cell projection	cellular component	IEA	12
GO:0008270	zinc ion binding	molecular function	IEA	367
GO:0005737	cytoplasm	cellular component	IDA[18451096]	781
GO:0033628	regulation of cell adhesion mediated by integrin	biological process	IEA	2
GO:0003712	transcription cofactor activity	molecular function	IDA[18451096]	18
GO:0005886	plasma membrane	cellular component	IDA[17640867]	839

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with LPXN (count: 68)

Gene Symbol	Pathway Count	Pathway List
CTNND2	7	nucleus; protein binding; cell adhesion; transcription, DNA-dependent; regulation of transcription, DNA-dependent; signal transduction; cytoplasm;
CTNND1	7	nucleus; protein binding; cell adhesion; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm; plasma membrane;
APBB1	7	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; signal transduction; cytoplasm; plasma membrane;
CREBBP	7	nucleus; protein binding; protein complex assembly; regulation of transcription, DNA-dependent; signal transduction; zinc ion binding; cytoplasm;
SNCA	6	nucleus; perinuclear region of cytoplasm; protein binding; zinc ion binding; cytoplasm; plasma membrane;
PTPN14	6	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm; transcription cofactor activity;
APC	6	nucleus; protein binding; cell adhesion; protein complex assembly; cytoplasm; plasma membrane;
FLII	6	nucleus; protein binding; focal adhesion; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
CBL	6	nucleus; protein binding; regulation of transcription, DNA-dependent; zinc ion binding; cytoplasm; plasma membrane;
TPPP	6	nucleus; perinuclear region of cytoplasm; protein binding; focal adhesion; cytoplasm; plasma membrane;
ERBB2	6	nucleus; perinuclear region of cytoplasm; protein binding; transcription, DNA-dependent; signal transduction; plasma membrane;
MAPK1	6	nucleus; protein binding; focal adhesion; transcription, DNA-dependent; signal transduction; cytoplasm;
NR4A2	6	nucleus; protein binding; transcription, DNA-dependent; signal transduction; zinc ion binding; cytoplasm;
IGHMBP2	6	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; zinc ion binding; cytoplasm;
PNN	6	nucleus; cell adhesion; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm; plasma membrane;
WASL	6	nucleus; protein binding; protein complex assembly; transcription, DNA-dependent; regulation of transcription, DNA-dependent; plasma membrane;
PDPK1	6	protein binding; focal adhesion; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm; plasma membrane;
ADAM17	6	protein binding; focal adhesion; cell adhesion; zinc ion binding; cytoplasm; plasma membrane;
EHD3	5	nucleus; perinuclear region of cytoplasm; protein binding; cytoplasm; plasma membrane;
GSK3B	5	nucleus; perinuclear region of cytoplasm; protein binding; cytoplasm; plasma membrane;
PDE2A	5	nucleus; perinuclear region of cytoplasm; protein binding; cytoplasm; plasma membrane;
PCGF3	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; zinc ion binding;
ZNF77	5	nucleus; transcription, DNA-dependent; regulation of transcription, DNA-dependent; zinc ion binding; cytoplasm;
BCL11A	5	nucleus; transcription, DNA-dependent; regulation of transcription, DNA-dependent; zinc ion binding; cytoplasm;
MALT1	5	nucleus; perinuclear region of cytoplasm; protein binding; cytoplasm; plasma membrane;
RRP8	5	nucleus; protein binding; transcription, DNA-dependent; cytoplasm; plasma membrane;
PSPC1	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
HABP4	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
ZNF205	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; zinc ion binding;
DPF2	5	nucleus; transcription, DNA-dependent; regulation of transcription, DNA-dependent; zinc ion binding; cytoplasm;
BIRC2	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; zinc ion binding;
PGR	5	nucleus; protein binding; signal transduction; zinc ion binding; cytoplasm;
HMGA1	5	nucleus; protein binding; protein complex assembly; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
MGRN1	5	nucleus; protein binding; zinc ion binding; cytoplasm; plasma membrane;
EEF1D	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; signal transduction;
ZNF263	5	nucleus; transcription, DNA-dependent; regulation of transcription, DNA-dependent; zinc ion binding; cytoplasm;
PRKAA1	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; signal transduction;
ZNF646	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; zinc ion binding;
ACHE	5	nucleus; perinuclear region of cytoplasm; protein binding; cell adhesion; plasma membrane;
HINFP	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; zinc ion binding;
CACNA1A	5	nucleus; protein binding; cell projection; cytoplasm; plasma membrane;
NF2	5	nucleus; perinuclear region of cytoplasm; protein binding; cytoplasm; plasma membrane;
PARK2	5	nucleus; perinuclear region of cytoplasm; protein binding; zinc ion binding; cytoplasm;
DAXX	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
SLC9A3R2	5	nucleus; protein binding; protein complex assembly; cytoplasm; plasma membrane;
SIPA1	5	nucleus; perinuclear region of cytoplasm; negative regulation of cell adhesion; protein binding; signal transduction;
PRKD1	5	nucleus; protein binding; signal transduction; cytoplasm; plasma membrane;
AIP	5	nucleus; protein binding; signal transduction; cytoplasm; plasma membrane;
RNF40	5	nucleus; protein binding; zinc ion binding; cytoplasm; plasma membrane;
AXIN1	5	nucleus; perinuclear region of cytoplasm; protein binding; cytoplasm; plasma membrane;
ARVCF	5	nucleus; protein binding; cell adhesion; cytoplasm; plasma membrane;
SAP18	5	nucleus; protein binding; transcription, DNA-dependent; cytoplasm; plasma membrane;
TRIM22	5	nucleus; transcription, DNA-dependent; regulation of transcription, DNA-dependent; zinc ion binding; cytoplasm;
TERF2IP	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
BSPRY	5	nucleus; perinuclear region of cytoplasm; focal adhesion; zinc ion binding; cytoplasm;
MAGI2	5	nucleus; perinuclear region of cytoplasm; protein binding; cytoplasm; plasma membrane;
SCAI	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
LMX1B	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; zinc ion binding;
HES1	5	nucleus; protein binding; cell adhesion; protein complex assembly; cytoplasm;
IL16	5	nucleus; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm; plasma membrane;
AATF	5	nucleus; protein binding; focal adhesion; cell adhesion; cytoplasm;
BCAR1	5	protein binding; focal adhesion; cell adhesion; cytoplasm; plasma membrane;
TRAF1	5	protein binding; protein complex assembly; signal transduction; zinc ion binding; cytoplasm;
TGFB1I1	5	protein binding; focal adhesion; cell adhesion; zinc ion binding; cytoplasm;
ARPC2	5	protein binding; focal adhesion; cell projection; cytoplasm; plasma membrane;
ADAM8	5	protein binding; podosome; zinc ion binding; cytoplasm; plasma membrane;
TRAF7	5	protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; zinc ion binding; plasma membrane;
DTNA	5	protein binding; signal transduction; zinc ion binding; cytoplasm; plasma membrane;

Genes shared at least 2 KEGG pathways with LPXN (count: 0)

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Region: chr11:58294344..58345693 View in gBrowse