ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	LPXN
Symbol Alias	LDPL
Approved Name	leupaxin
Location	11
Position	chr11:58294344-58345693, -
External Links	HGNC: 14061 Entrez Gene: 9404 Ensembl: ENSG00000110031 UCSC: uc001nmw.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048471	perinuclear region of cytoplasm	Cellular Component		87
GO:0042995	cell projection	Cellular Component		12
GO:0033628	regulation of cell adhesion mediated by integrin	Biological Process		2
GO:0008270	zinc ion binding	Molecular Function		323
GO:0007165	signal transduction	Biological Process	TAS[9565592]	171
GO:0007162	negative regulation of cell adhesion	Biological Process		6
GO:0007155	cell adhesion	Biological Process		86
GO:0006461	protein complex assembly	Biological Process	TAS[9565592]	28
GO:0050859	negative regulation of B cell receptor signaling pathway	Biological Process	IDA[17640867]	1
GO:0002102	podosome	Cellular Component	IDA[12674328]	3
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0006355	regulation of transcription, DNA-dependent	Biological Process		158
GO:0005886	plasma membrane	Cellular Component	IDA[17640867]	772
GO:0005925	focal adhesion	Cellular Component		26
GO:0005634	nucleus	Cellular Component	IDA[18451096]	770
GO:0005737	cytoplasm	Cellular Component	IDA[18451096]	690
GO:0003712	transcription cofactor activity	Molecular Function	IDA[18451096]	17
GO:0005515	protein binding	Molecular Function		910

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with LPXN (count: 63)

Gene Symbol	Pathway Count	Pathway List
PRKCB	7	zinc ion binding; signal transduction; transcription, DNA-dependent; plasma membrane; nucleus; cytoplasm; protein binding;
APBB1	7	signal transduction; transcription, DNA-dependent; regulation of transcription, DNA-dependent; plasma membrane; nucleus; cytoplasm; protein binding;
CTNND2	7	signal transduction; cell adhesion; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; cytoplasm; protein binding;
CTNND1	7	cell adhesion; transcription, DNA-dependent; regulation of transcription, DNA-dependent; plasma membrane; nucleus; cytoplasm; protein binding;
ERBB2	6	perinuclear region of cytoplasm; signal transduction; transcription, DNA-dependent; plasma membrane; nucleus; protein binding;
SNCA	6	perinuclear region of cytoplasm; zinc ion binding; plasma membrane; nucleus; cytoplasm; protein binding;
TPPP	6	perinuclear region of cytoplasm; plasma membrane; focal adhesion; nucleus; cytoplasm; protein binding;
ADAM17	6	zinc ion binding; cell adhesion; plasma membrane; focal adhesion; cytoplasm; protein binding;
CBL	6	zinc ion binding; regulation of transcription, DNA-dependent; plasma membrane; nucleus; cytoplasm; protein binding;
IGHMBP2	6	zinc ion binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; cytoplasm; protein binding;
NR4A2	6	zinc ion binding; signal transduction; transcription, DNA-dependent; nucleus; cytoplasm; protein binding;
MAPK1	6	signal transduction; transcription, DNA-dependent; focal adhesion; nucleus; cytoplasm; protein binding;
APC	6	cell adhesion; protein complex assembly; plasma membrane; nucleus; cytoplasm; protein binding;
WASL	6	protein complex assembly; transcription, DNA-dependent; regulation of transcription, DNA-dependent; plasma membrane; nucleus; protein binding;
FLII	6	transcription, DNA-dependent; regulation of transcription, DNA-dependent; focal adhesion; nucleus; cytoplasm; protein binding;
PTPN14	6	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; cytoplasm; transcription cofactor activity; protein binding;
ACHE	5	perinuclear region of cytoplasm; cell adhesion; plasma membrane; nucleus; protein binding;
BSPRY	5	perinuclear region of cytoplasm; zinc ion binding; focal adhesion; nucleus; cytoplasm;
EHD3	5	perinuclear region of cytoplasm; plasma membrane; nucleus; cytoplasm; protein binding;
GSK3B	5	perinuclear region of cytoplasm; plasma membrane; nucleus; cytoplasm; protein binding;
MAGI2	5	perinuclear region of cytoplasm; plasma membrane; nucleus; cytoplasm; protein binding;
MALT1	5	perinuclear region of cytoplasm; plasma membrane; nucleus; cytoplasm; protein binding;
NF2	5	perinuclear region of cytoplasm; plasma membrane; nucleus; cytoplasm; protein binding;
PARK2	5	perinuclear region of cytoplasm; zinc ion binding; nucleus; cytoplasm; protein binding;
PDE2A	5	perinuclear region of cytoplasm; plasma membrane; nucleus; cytoplasm; protein binding;
SIPA1	5	perinuclear region of cytoplasm; signal transduction; negative regulation of cell adhesion; nucleus; protein binding;
ARPC2	5	cell projection; plasma membrane; focal adhesion; cytoplasm; protein binding;
CACNA1A	5	cell projection; plasma membrane; nucleus; cytoplasm; protein binding;
ADAM8	5	zinc ion binding; podosome; plasma membrane; cytoplasm; protein binding;
BCL11A	5	zinc ion binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; cytoplasm;
BIRC2	5	zinc ion binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; protein binding;
DPF2	5	zinc ion binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; cytoplasm;
DTNA	5	zinc ion binding; signal transduction; plasma membrane; cytoplasm; protein binding;
HINFP	5	zinc ion binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; protein binding;
LMX1B	5	zinc ion binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; protein binding;
PCGF3	5	zinc ion binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; protein binding;
PGR	5	zinc ion binding; signal transduction; nucleus; cytoplasm; protein binding;
RFWD2	5	zinc ion binding; focal adhesion; nucleus; cytoplasm; protein binding;
RNF40	5	zinc ion binding; plasma membrane; nucleus; cytoplasm; protein binding;
TGFB1I1	5	zinc ion binding; cell adhesion; focal adhesion; cytoplasm; protein binding;
TRAF1	5	zinc ion binding; signal transduction; protein complex assembly; cytoplasm; protein binding;
TRIM22	5	zinc ion binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; cytoplasm;
ZNF263	5	zinc ion binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; cytoplasm;
ZNF646	5	zinc ion binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; protein binding;
ZNF77	5	zinc ion binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; cytoplasm;
AIP	5	signal transduction; plasma membrane; nucleus; cytoplasm; protein binding;
EEF1D	5	signal transduction; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; protein binding;
PRKAA1	5	signal transduction; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; protein binding;
PRKD1	5	signal transduction; plasma membrane; nucleus; cytoplasm; protein binding;
WWP1	5	signal transduction; plasma membrane; nucleus; cytoplasm; protein binding;
AATF	5	cell adhesion; focal adhesion; nucleus; cytoplasm; protein binding;
ARVCF	5	cell adhesion; plasma membrane; nucleus; cytoplasm; protein binding;
BCAR1	5	cell adhesion; plasma membrane; focal adhesion; cytoplasm; protein binding;
HES1	5	cell adhesion; protein complex assembly; nucleus; cytoplasm; protein binding;
HMGA1	5	protein complex assembly; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; protein binding;
DAXX	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; cytoplasm; protein binding;
HABP4	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; cytoplasm; protein binding;
IL16	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; plasma membrane; nucleus; cytoplasm;
PSPC1	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; cytoplasm; protein binding;
RRP8	5	transcription, DNA-dependent; plasma membrane; nucleus; cytoplasm; protein binding;
SAP18	5	transcription, DNA-dependent; plasma membrane; nucleus; cytoplasm; protein binding;
SCAI	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; cytoplasm; protein binding;
TERF2IP	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; cytoplasm; protein binding;

Genes shared at least 2 KEGG pathways with LPXN (count: 0)

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Region: chr11:58294344..58345693 View in gBrowse