ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SIPA1
Symbol Alias	SPA1
Approved Name	signal-induced proliferation-associated 1
Location	11q13.3
Position	chr11:65405568-65418401, +
External Links	HGNC: 10885 Entrez Gene: 6494 Ensembl: ENSG00000213445 UCSC: uc001ofb.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008283	cell proliferation	Biological Process	TAS[9346962]	60
GO:0007165	signal transduction	Biological Process	TAS[9346962]	171
GO:0016020	membrane	Cellular Component		139
GO:0012505	endomembrane system	Cellular Component		16
GO:0005829	cytosol	Cellular Component		447
GO:0005634	nucleus	Cellular Component	IC[9183624]	770
GO:0007162	negative regulation of cell adhesion	Biological Process	NAS[10373454]	6
GO:0007010	cytoskeleton organization	Biological Process	NAS[12059963]	12
GO:0046582	Rap GTPase activator activity	Molecular Function	NAS[9346962]	1
GO:0045786	negative regulation of cell cycle	Biological Process	NAS[7799964]	9
GO:0048471	perinuclear region of cytoplasm	Cellular Component		87
GO:0032854	positive regulation of Rap GTPase activity	Biological Process	NAS[9346962]	1
GO:0030308	negative regulation of cell growth	Biological Process	NAS[9183624]	21
GO:0043547	positive regulation of GTPase activity	Biological Process	TAS[9346962]	10
GO:0035556	intracellular signal transduction	Biological Process	NAS[9346962]	44
GO:0005096	GTPase activator activity	Molecular Function	TAS[9346962]	23
GO:0005515	protein binding	Molecular Function		910

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04670	Leukocyte transendothelial migration	22	Leukocyte migaration from the blood into tissues is vital fo...... Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. In this process, alphaL /beta2 integrin activates through Vav1, RhoA, which subsequently activates the kinase p160ROCK. ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton. Moreover, Leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. VCAM-1 is involved in the opening of the "endothelial passage" through which leukocytes can extravasate. In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metallopoteinases and loss of VE-cadherin-mediated adhesion. More...

Genes shared at least 5 GO terms with SIPA1 (count: 8)

Gene Symbol	Pathway Count	Pathway List
ACHE	5	cell proliferation; membrane; nucleus; perinuclear region of cytoplasm; protein binding;
ERBB2	5	cell proliferation; signal transduction; nucleus; perinuclear region of cytoplasm; protein binding;
PRKD1	5	cell proliferation; signal transduction; cytosol; nucleus; protein binding;
LPXN	5	signal transduction; nucleus; negative regulation of cell adhesion; perinuclear region of cytoplasm; protein binding;
PRKCB	5	signal transduction; cytosol; nucleus; intracellular signal transduction; protein binding;
RASA1	5	signal transduction; cytosol; negative regulation of cell adhesion; intracellular signal transduction; protein binding;
ARRB1	5	cytosol; nucleus; positive regulation of GTPase activity; GTPase activator activity; protein binding;
GSK3B	5	cytosol; nucleus; perinuclear region of cytoplasm; intracellular signal transduction; protein binding;

Genes shared at least 2 KEGG pathways with SIPA1 (count: 0)

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Region: chr11:65405568..65418401 View in gBrowse