ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PTPN14
Symbol Alias	PEZ
Approved Name	protein tyrosine phosphatase, non-receptor type 14
Location	1q32.2
Position	chr1:214522039-214725792, -
External Links	HGNC: 9647 Entrez Gene: 5784 Ensembl: ENSG00000152104 UCSC: uc001hkk.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by literature SNP

Gene related studies (count: 0)

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs6657749	Chr1:214576513(Fwd)	intron_variant	2(0/2/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004725	protein tyrosine phosphatase activity	Molecular Function		19
GO:0005515	protein binding	Molecular Function		910
GO:0005634	nucleus	Cellular Component		770
GO:0005737	cytoplasm	Cellular Component		690
GO:0001946	lymphangiogenesis	Biological Process		4
GO:0003712	transcription cofactor activity	Molecular Function		17
GO:0030971	receptor tyrosine kinase binding	Molecular Function		2
GO:0008285	negative regulation of cell proliferation	Biological Process		59
GO:0046825	regulation of protein export from nucleus	Biological Process		2
GO:0035335	peptidyl-tyrosine dephosphorylation	Biological Process	TAS[7733990]	11
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0005856	cytoskeleton	Cellular Component		54
GO:0006470	protein dephosphorylation	Biological Process	TAS[7733990]	18
GO:0006355	regulation of transcription, DNA-dependent	Biological Process		158

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PTPN14 (count: 22)

Gene Symbol	Pathway Count	Pathway List
PTPN3	6	protein tyrosine phosphatase activity; protein binding; cytoplasm; peptidyl-tyrosine dephosphorylation; cytoskeleton; protein dephosphorylation;
LPXN	6	protein binding; nucleus; cytoplasm; transcription cofactor activity; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
DUSP12	5	protein tyrosine phosphatase activity; nucleus; cytoplasm; peptidyl-tyrosine dephosphorylation; protein dephosphorylation;
DUSP2	5	protein tyrosine phosphatase activity; protein binding; nucleus; peptidyl-tyrosine dephosphorylation; protein dephosphorylation;
EYA4	5	protein tyrosine phosphatase activity; nucleus; cytoplasm; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
MTMR2	5	protein tyrosine phosphatase activity; protein binding; nucleus; cytoplasm; protein dephosphorylation;
PTPRK	5	protein tyrosine phosphatase activity; protein binding; negative regulation of cell proliferation; peptidyl-tyrosine dephosphorylation; protein dephosphorylation;
SSH3	5	protein tyrosine phosphatase activity; nucleus; cytoplasm; cytoskeleton; protein dephosphorylation;
APBB1	5	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
CTNND1	5	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
CTNND2	5	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
DAXX	5	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
FLII	5	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
HABP4	5	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
HMGA1	5	protein binding; nucleus; negative regulation of cell proliferation; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
IGHMBP2	5	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
MAPK1	5	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; cytoskeleton;
MEN1	5	protein binding; nucleus; cytoplasm; negative regulation of cell proliferation; transcription, DNA-dependent;
NF2	5	protein binding; nucleus; cytoplasm; negative regulation of cell proliferation; cytoskeleton;
PSPC1	5	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
SCAI	5	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
TERF2IP	5	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; regulation of transcription, DNA-dependent;

Genes shared at least 2 KEGG pathways with PTPN14 (count: 0)

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Region: chr1:214522039..214725792 View in gBrowse