ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PTPN14
Symbol Alias	PEZ
Approved Name	protein tyrosine phosphatase, non-receptor type 14
Location	1q32.2
Position	chr1:214522039-214725792, -1
External Links	HGNC: 9647 Entrez Gene: 5784 Ensembl: ENSG00000152104 UCSC: uc001hkk.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by Literature SNP

Gene related studies (count: 0)

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs6657749	chr1:214576513(Fwd)	intron_variant	2(0/2/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006351	transcription, DNA-dependent	biological process	IEA	281
GO:0005856	cytoskeleton	cellular component	IEA	56
GO:0030971	receptor tyrosine kinase binding	molecular function	IPI	3
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0005634	nucleus	cellular component	IDA	877
GO:0003712	transcription cofactor activity	molecular function	IMP	18
GO:0035335	peptidyl-tyrosine dephosphorylation	biological process	IMP; TAS[7733990]	11
GO:0004725	protein tyrosine phosphatase activity	molecular function	IMP	19
GO:0005515	protein binding	molecular function	IPI	1015
GO:0001946	lymphangiogenesis	biological process	IMP	4
GO:0006470	protein dephosphorylation	biological process	TAS[7733990]	19
GO:0006355	regulation of transcription, DNA-dependent	biological process	IEA	182
GO:0008285	negative regulation of cell proliferation	biological process	IMP	65
GO:0046825	regulation of protein export from nucleus	biological process	IDA	2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PTPN14 (count: 23)

Gene Symbol	Pathway Count	Pathway List
LPXN	6	transcription, DNA-dependent; cytoplasm; nucleus; transcription cofactor activity; protein binding; regulation of transcription, DNA-dependent;
PTPN3	6	cytoskeleton; cytoplasm; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein binding; protein dephosphorylation;
PSPC1	5	transcription, DNA-dependent; cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent;
CTNND2	5	transcription, DNA-dependent; cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent;
SCAI	5	transcription, DNA-dependent; cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent;
IGHMBP2	5	transcription, DNA-dependent; cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent;
FLII	5	transcription, DNA-dependent; cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent;
TERF2IP	5	transcription, DNA-dependent; cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent;
CTNND1	5	transcription, DNA-dependent; cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent;
MEN1	5	transcription, DNA-dependent; cytoplasm; nucleus; protein binding; negative regulation of cell proliferation;
EYA4	5	transcription, DNA-dependent; cytoplasm; nucleus; protein tyrosine phosphatase activity; regulation of transcription, DNA-dependent;
DAXX	5	transcription, DNA-dependent; cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent;
HABP4	5	transcription, DNA-dependent; cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent;
HMGA1	5	transcription, DNA-dependent; nucleus; protein binding; regulation of transcription, DNA-dependent; negative regulation of cell proliferation;
MAPK1	5	transcription, DNA-dependent; cytoskeleton; cytoplasm; nucleus; protein binding;
APBB1	5	transcription, DNA-dependent; cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent;
NF2	5	cytoskeleton; cytoplasm; nucleus; protein binding; negative regulation of cell proliferation;
SSH3	5	cytoskeleton; cytoplasm; nucleus; protein tyrosine phosphatase activity; protein dephosphorylation;
DNAJA3	5	receptor tyrosine kinase binding; cytoplasm; nucleus; protein binding; negative regulation of cell proliferation;
DUSP12	5	cytoplasm; nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein dephosphorylation;
MTMR2	5	cytoplasm; nucleus; protein tyrosine phosphatase activity; protein binding; protein dephosphorylation;
DUSP2	5	nucleus; peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein binding; protein dephosphorylation;
PTPRK	5	peptidyl-tyrosine dephosphorylation; protein tyrosine phosphatase activity; protein binding; protein dephosphorylation; negative regulation of cell proliferation;

Genes shared at least 2 KEGG pathways with PTPN14 (count: 0)

View in gBrowse

Region: chr1:214522039..214725792 View in gBrowse