ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CRBN
Previous Symbol	MRT2A
Approved Name	cereblon
Previous Name	mental retardation, non-syndromic, autosomal recessive, 2A
Location	3p26.3
Position	chr3:3190676-3221401, -
External Links	HGNC: 30185 Entrez Gene: 51185 Ensembl: ENSG00000113851 UCSC: uc003bpq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_15	chr3:2969491-4461303 (NCBI Build 36.1 (hg18))	1538470	3p26.3-3p26.2	Loss

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

ID	Name	Type	No. of Genes in ADHDgene
GO:0004176	ATP-dependent peptidase activity	Molecular Function	2
GO:0005515	protein binding	Molecular Function	910
GO:0005634	nucleus	Cellular Component	770
GO:0005730	nucleolus	Cellular Component	243
GO:0034766	negative regulation of ion transmembrane transport	Biological Process	1
GO:0032463	negative regulation of protein homooligomerization	Biological Process	2
GO:0090073	positive regulation of protein homodimerization activity	Biological Process	2
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	Biological Process	16
GO:0016020	membrane	Cellular Component	139
GO:0005737	cytoplasm	Cellular Component	690
GO:0031464	Cul4A-RING ubiquitin ligase complex	Cellular Component	3
GO:0016567	protein ubiquitination	Biological Process	41

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CRBN (count: 9)

Gene Symbol	Pathway Count	Pathway List
KLHL20	6	protein binding; nucleus; nucleolus; proteasomal ubiquitin-dependent protein catabolic process; cytoplasm; protein ubiquitination;
ARRB1	5	protein binding; nucleus; proteasomal ubiquitin-dependent protein catabolic process; cytoplasm; protein ubiquitination;
ARRB2	5	protein binding; nucleus; proteasomal ubiquitin-dependent protein catabolic process; cytoplasm; protein ubiquitination;
DDB1	5	protein binding; nucleus; proteasomal ubiquitin-dependent protein catabolic process; cytoplasm; Cul4A-RING ubiquitin ligase complex;
MALT1	5	protein binding; nucleus; nucleolus; cytoplasm; protein ubiquitination;
RAD23B	5	protein binding; nucleus; nucleolus; proteasomal ubiquitin-dependent protein catabolic process; cytoplasm;
RCHY1	5	protein binding; nucleus; nucleolus; cytoplasm; protein ubiquitination;
RFWD2	5	protein binding; nucleus; nucleolus; cytoplasm; protein ubiquitination;
WWP1	5	protein binding; nucleus; proteasomal ubiquitin-dependent protein catabolic process; cytoplasm; protein ubiquitination;

Genes shared at least 2 KEGG pathways with CRBN (count: 0)

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Region: chr3:3190676..3221401 View in gBrowse