ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0016567
Name	protein ubiquitination
Type	biological process
No. of Genes in ADHDgene	48
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 48)

Literature-origin genes (count: 3)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
TRIM32	tripartite motif containing 32	9q33.1	1(0/0/1)	IDA[16816390]
ARRB1	arrestin, beta 1	11q13	2(1/1/0)	IMP[15878855]
ARRB2	arrestin, beta 2	17p13	1(1/0/0)	IMP[15878855]

Genes from other sources (count: 45)

Approved Symbol	Approved Name	Source	Evidence[PMID]
FBXO25	F-box protein 25	Mapped by CNV	ISS; NAS[10531035]
FBXL7	F-box and leucine-rich repeat protein 7	Mapped by significant region	ISS
RAB40C	RAB40C, member RAS oncogene family	Mapped by significant region	IEA
RNF169	ring finger protein 169	Mapped by significant region	IEA
BARD1	BRCA1 associated RING domain 1	Mapped by significant region	NAS[15905410]
FBXO4	F-box protein 4	Mapped by significant region	IDA[10531035]
SOCS1	suppressor of cytokine signaling 1	Mapped by significant region	IEA
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	Mapped by significant region	NAS[11244092]
MARCH11	membrane-associated ring finger (C3HC4) 11	Mapped by significant region	IEA
SYVN1	synovial apoptosis inhibitor 1, synoviolin	Mapped by significant region	IEA
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	Mapped by significant region	IDA[15125833]
RFWD3	ring finger and WD repeat domain 3	Mapped by significant region	IDA
MKRN3	makorin ring finger protein 3	Mapped by CNV; Mapped by significant region	IEA
HERC2	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Mapped by significant region	IDA
TRAF7	TNF receptor-associated factor 7, E3 ubiquitin protein ligase	Mapped by significant region	IDA[14743216]
E4F1	E4F transcription factor 1	Mapped by significant region	IEA
KLHL7	kelch-like family member 7	Mapped by significant region	IDA; IEA
CCNF	cyclin F	Mapped by significant region	IDA
RCHY1	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase	Mapped by CNV	IDA[19043414]
CUL5	cullin 5	Mapped by significant region; Mapped by PBA pathway	IEA
TRIM22	tripartite motif containing 22	Mapped by CNV	IEA
CBL	Cbl proto-oncogene, E3 ubiquitin protein ligase	Mapped by significant region	TAS[15465819]
CRBN	cereblon	Mapped by CNV	IEA; IMP
GAN	gigaxonin	Mapped by significant region	IDA[15983046]; IEA
DTX4	deltex 4, E3 ubiquitin ligase	Mapped by significant region	IEA
RNF19A	ring finger protein 19A, RBR E3 ubiquitin protein ligase	Mapped by PBA pathway	IEA
KCTD13	potassium channel tetramerization domain containing 13	Mapped by CNV	IDA[19782033]
FBXW2	F-box and WD repeat domain containing 2	Mapped by significant region	TAS[10531035]
KLHL20	kelch-like family member 20	Mapped by significant region	IDA
FBXO31	F-box protein 31	Mapped by significant region	IEA
RNF25	ring finger protein 25	Mapped by significant region	ISS
TRIP12	thyroid hormone receptor interactor 12	Mapped by PBA pathway	NAS
NEUROD2	neuronal differentiation 2	Mapped by LD-proxy	ISS
TCEB2	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	Mapped by significant region	IEA
KLHL22	kelch-like family member 22	Mapped by CNV	IEA
PELI3	pellino E3 ubiquitin protein ligase family member 3	Mapped by significant region	IEA
RNF138	ring finger protein 138, E3 ubiquitin protein ligase	Mapped by significant region	IEA
KLHL36	kelch-like family member 36	Mapped by CNV; Mapped by significant region	IEA
UBA6	ubiquitin-like modifier activating enzyme 6	Mapped by significant region	IEA; IMP[17889673]
UNKL	unkempt family zinc finger-like	Mapped by significant region	IEA
BIRC6	baculoviral IAP repeat containing 6	Mapped by CNV	TAS[18329369]
SPSB3	splA/ryanodine receptor domain and SOCS box containing 3	Mapped by significant region	IEA
PLK1	polo-like kinase 1	Mapped by significant region	IDA[16885022]
ASB15	ankyrin repeat and SOCS box containing 15	Mapped by CNV	IEA
ZBTB16	zinc finger and BTB domain containing 16	Mapped by significant region	IEA