ADHDgene Database

Gene Report

Basic Info

Approved Symbol	UBA6
Previous Symbol	UBE1L2
Symbol Alias	FLJ10808
Approved Name	ubiquitin-like modifier activating enzyme 6
Previous Name	ubiquitin-activating enzyme E1-like 2
Name Alias	UBA6, ubiquitin-activating enzyme E1
Location	4q13.2
Position	chr4:68481479-68566897, -
External Links	HGNC: 25581 Entrez Gene: 55236 Ensembl: ENSG00000033178 UCSC: uc003hdg.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
4q13.2	chr4:66600000-70500000	1 (1/0/0)

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016874	ligase activity	Molecular Function		12
GO:0019780	FAT10 activating enzyme activity	Molecular Function	IMP[17889673]	1
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IMP[17889673]	25
GO:0016567	protein ubiquitination	Biological Process	IMP[17889673]	41
GO:0005524	ATP binding	Molecular Function		228
GO:0005737	cytoplasm	Cellular Component		690
GO:0005515	protein binding	Molecular Function	IPI[17889673]	910

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04120	Ubiquitin mediated proteolysis	29	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...

Genes shared at least 5 GO terms with UBA6 (count: 0)

Genes shared at least 2 KEGG pathways with UBA6 (count: 0)

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Region: chr4:68481479..68566897 View in gBrowse