ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MIF
Previous Symbol	GLIF
Symbol Alias	GIF
Approved Name	macrophage migration inhibitory factor (glycosylation-inhibiting factor)
Location	22q11.23
Position	chr22:24236191-24237414, +
External Links	HGNC: 7097 Entrez Gene: 4282 Ensembl: ENSG00000240972 UCSC: uc002zyr.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_37	chr22:22020325-23326630 (NCBI Build 36.1 (hg18))	1306306	22q11.23	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 45)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 45)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004167	dopachrome isomerase activity	Molecular Function	IDA[17526494]	1
GO:0002906	negative regulation of mature B cell apoptotic process	Biological Process		1
GO:0001516	prostaglandin biosynthetic process	Biological Process	IDA[12782713]	3
GO:0005515	protein binding	Molecular Function	IPI[17526494]	910
GO:0005126	cytokine receptor binding	Molecular Function	IPI[17045821]	1
GO:0005125	cytokine activity	Molecular Function	IDA[12782713]	19
GO:0005102	receptor binding	Molecular Function	IPI[12782713]	61
GO:0006954	inflammatory response	Biological Process		51
GO:0005737	cytoplasm	Cellular Component		690
GO:0005615	extracellular space	Cellular Component		126
GO:0005576	extracellular region	Cellular Component	IDA[12782713]	240
GO:0009986	cell surface	Cellular Component	IDA[12782713]	70
GO:0008283	cell proliferation	Biological Process	IDA[12782713]	60
GO:0007569	cell aging	Biological Process		4
GO:0007166	cell surface receptor signaling pathway	Biological Process	IDA[12782713]	35
GO:0010629	negative regulation of gene expression	Biological Process	IDA[10562313]	13
GO:0010739	positive regulation of protein kinase A signaling cascade	Biological Process	IDA[17045821]	2
GO:0019752	carboxylic acid metabolic process	Biological Process	IDA[12782713]	3
GO:0030330	DNA damage response, signal transduction by p53 class mediator	Biological Process		2
GO:0030890	positive regulation of B cell proliferation	Biological Process	IDA[12782713]	4
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	Biological Process		1
GO:0032269	negative regulation of cellular protein metabolic process	Biological Process		1
GO:0033033	negative regulation of myeloid cell apoptotic process	Biological Process		1
GO:0033138	positive regulation of peptidyl-serine phosphorylation	Biological Process	IDA[17045821]	10
GO:0042056	chemoattractant activity	Molecular Function	IDA[19602265]	5
GO:0042327	positive regulation of phosphorylation	Biological Process	IDA[12782713]	5
GO:0043030	regulation of macrophage activation	Biological Process	NAS[12782713]	4
GO:0043066	negative regulation of apoptotic process	Biological Process	IDA[17045821]	77
GO:0043406	positive regulation of MAP kinase activity	Biological Process		10
GO:0043498	cell surface binding	Molecular Function	IDA[12782713]	3
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	Biological Process	IDA[17045821]	2
GO:0048146	positive regulation of fibroblast proliferation	Biological Process	IDA[12782713]	4
GO:0045087	innate immune response	Biological Process		54
GO:0050715	positive regulation of cytokine secretion	Biological Process	IDA[19602265]	8
GO:0050178	phenylpyruvate tautomerase activity	Molecular Function	IDA[16285950]	1
GO:0050918	positive chemotaxis	Biological Process	IDA[19602265]	7
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Biological Process	IDA[17045821]	14
GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response	Biological Process		1
GO:0061078	positive regulation of prostaglandin secretion involved in immune response	Biological Process		1
GO:0070374	positive regulation of ERK1 and ERK2 cascade	Biological Process	IDA[17045821]	22
GO:0070207	protein homotrimerization	Biological Process	IPI[17526494]	2
GO:0090238	positive regulation of arachidonic acid secretion	Biological Process		3
GO:0071157	negative regulation of cell cycle arrest	Biological Process	IDA[10562313]	3
GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	Biological Process		2
GO:0090344	negative regulation of cell aging	Biological Process	IDA[10562313]	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00360	Phenylalanine metabolism	8
hsa00350	Tyrosine metabolism	15

Genes shared at least 5 GO terms with MIF (count: 31)

Gene Symbol	Pathway Count	Pathway List
VEGFA	13	protein binding; cytokine activity; cytoplasm; extracellular space; extracellular region; cell surface; positive regulation of peptidyl-serine phosphorylation; chemoattractant activity; negative regulation of apoptotic process; positive regulation of MAP kinase activity; cell surface binding; positive chemotaxis; positive regulation of peptidyl-tyrosine phosphorylation;
FGF10	10	extracellular space; extracellular region; cell surface; chemoattractant activity; negative regulation of apoptotic process; positive regulation of fibroblast proliferation; positive chemotaxis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of ERK1 and ERK2 cascade; negative regulation of cell cycle arrest;
VEGFB	9	protein binding; extracellular space; extracellular region; negative regulation of gene expression; chemoattractant activity; negative regulation of apoptotic process; positive chemotaxis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of ERK1 and ERK2 cascade;
IL6	8	cytokine activity; inflammatory response; extracellular space; extracellular region; positive regulation of peptidyl-serine phosphorylation; negative regulation of apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of ERK1 and ERK2 cascade;
CLCF1	7	protein binding; cytokine activity; receptor binding; extracellular region; cell surface receptor signaling pathway; positive regulation of B cell proliferation; negative regulation of apoptotic process;
TIRAP	7	protein binding; inflammatory response; cell surface receptor signaling pathway; positive regulation of B cell proliferation; innate immune response; positive regulation of ERK1 and ERK2 cascade; positive regulation of chemokine (C-X-C motif) ligand 2 production;
ILK	6	protein binding; cytoplasm; cell proliferation; cell aging; positive regulation of phosphorylation; positive regulation of MAP kinase activity;
INS	6	protein binding; extracellular space; extracellular region; negative regulation of apoptotic process; positive regulation of cytokine secretion; positive regulation of peptidyl-tyrosine phosphorylation;
PIK3CG	6	protein binding; inflammatory response; cytoplasm; negative regulation of apoptotic process; positive regulation of MAP kinase activity; innate immune response;
PRKD1	6	protein binding; inflammatory response; cytoplasm; cell proliferation; positive regulation of peptidyl-serine phosphorylation; innate immune response;
PYCARD	6	protein binding; inflammatory response; cytoplasm; extracellular region; innate immune response; positive regulation of ERK1 and ERK2 cascade;
SNCA	6	protein binding; cytoplasm; extracellular region; positive regulation of peptidyl-serine phosphorylation; regulation of macrophage activation; negative regulation of apoptotic process;
C5	6	receptor binding; inflammatory response; extracellular space; extracellular region; cell surface receptor signaling pathway; innate immune response;
NTF3	6	receptor binding; extracellular region; positive regulation of peptidyl-serine phosphorylation; chemoattractant activity; positive chemotaxis; positive regulation of peptidyl-tyrosine phosphorylation;
ACHE	5	protein binding; extracellular space; extracellular region; cell surface; cell proliferation;
ARRB2	5	protein binding; receptor binding; cytoplasm; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of ERK1 and ERK2 cascade;
C1QTNF3	5	protein binding; extracellular space; negative regulation of gene expression; positive regulation of cytokine secretion; positive regulation of ERK1 and ERK2 cascade;
CCR5	5	protein binding; inflammatory response; cytoplasm; cell surface; cell surface receptor signaling pathway;
CRYAB	5	protein binding; cytoplasm; cell surface; negative regulation of gene expression; negative regulation of apoptotic process;
EREG	5	protein binding; extracellular space; extracellular region; positive regulation of phosphorylation; positive regulation of fibroblast proliferation;
FLT4	5	protein binding; cytoplasm; extracellular region; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade;
GHR	5	protein binding; extracellular space; extracellular region; cell surface; positive regulation of peptidyl-tyrosine phosphorylation;
INHA	5	protein binding; cytokine activity; receptor binding; extracellular region; cell surface receptor signaling pathway;
LPL	5	protein binding; receptor binding; extracellular space; extracellular region; cell surface;
RELA	5	protein binding; inflammatory response; cytoplasm; negative regulation of apoptotic process; innate immune response;
SEMA4D	5	protein binding; receptor binding; extracellular space; negative regulation of apoptotic process; positive regulation of peptidyl-tyrosine phosphorylation;
SYK	5	protein binding; cell proliferation; innate immune response; positive regulation of cytokine secretion; positive regulation of peptidyl-tyrosine phosphorylation;
TLR4	5	protein binding; cytoplasm; positive regulation of B cell proliferation; innate immune response; positive regulation of ERK1 and ERK2 cascade;
TNFAIP3	5	protein binding; inflammatory response; cytoplasm; negative regulation of apoptotic process; innate immune response;
TNFSF18	5	cytokine activity; receptor binding; extracellular space; cell surface; negative regulation of apoptotic process;
PLA2G1B	5	receptor binding; extracellular space; extracellular region; cell surface binding; positive regulation of fibroblast proliferation;

Genes shared at least 2 KEGG pathways with MIF (count: 6)

Gene Symbol	Pathway Count	Pathway List
ALDH3A1	2	Phenylalanine metabolism; Tyrosine metabolism;
ALDH3B1	2	Phenylalanine metabolism; Tyrosine metabolism;
ALDH3B2	2	Phenylalanine metabolism; Tyrosine metabolism;
DDC	2	Phenylalanine metabolism; Tyrosine metabolism;
MAOA	2	Phenylalanine metabolism; Tyrosine metabolism;
MAOB	2	Phenylalanine metabolism; Tyrosine metabolism;

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Region: chr22:24236191..24237414 View in gBrowse