ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TIRAP
Symbol Alias	Mal, wyatt
Approved Name	toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Previous Name	Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
Name Alias	MyD88 adapter-like
Location	11q24.2
Position	chr11:126152960-126168740, +
External Links	HGNC: 17192 Entrez Gene: 114609 Ensembl: ENSG00000150455 UCSC: uc001qdl.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 48)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 48)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Biological Process	TAS[19509286]	10
GO:0002224	toll-like receptor signaling pathway	Biological Process		10
GO:0005515	protein binding	Molecular Function	IPI[19509286]	910
GO:0005080	protein kinase C binding	Molecular Function	IPI[17161867]	9
GO:0032648	regulation of interferon-beta production	Biological Process		1
GO:0032735	positive regulation of interleukin-12 production	Biological Process		7
GO:0032738	positive regulation of interleukin-15 production	Biological Process	IDA[18583567]	1
GO:0032757	positive regulation of interleukin-8 production	Biological Process	IMP[16301656]	5
GO:0030674	protein binding, bridging	Molecular Function	NAS[19509286]	11
GO:0030890	positive regulation of B cell proliferation	Biological Process		4
GO:0032496	response to lipopolysaccharide	Biological Process	IDA[11544529]	22
GO:0032587	ruffle membrane	Cellular Component		12
GO:0007249	I-kappaB kinase/NF-kappaB cascade	Biological Process		5
GO:0008063	Toll signaling pathway	Biological Process		11
GO:0030099	myeloid cell differentiation	Biological Process		5
GO:0030139	endocytic vesicle	Cellular Component		12
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Molecular Function		4
GO:0005886	plasma membrane	Cellular Component		772
GO:0006954	inflammatory response	Biological Process		51
GO:0007166	cell surface receptor signaling pathway	Biological Process		35
GO:0045410	positive regulation of interleukin-6 biosynthetic process	Biological Process	IMP[16301656]	2
GO:0045088	regulation of innate immune response	Biological Process	IC[11544529]	3
GO:0045087	innate immune response	Biological Process		54
GO:0044130	negative regulation of growth of symbiont in host	Biological Process		4
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IMP[19509286]	27
GO:0042803	protein homodimerization activity	Molecular Function		113
GO:0035665	TIRAP-dependent toll-like receptor 4 signaling pathway	Biological Process	IDA[11544529]	1
GO:0035663	Toll-like receptor 2 binding	Molecular Function	IPI[19509286]	1
GO:0035662	Toll-like receptor 4 binding	Molecular Function	IPI[19509286]	1
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	Biological Process	IMP[19509286]	1
GO:0034142	toll-like receptor 4 signaling pathway	Biological Process		11
GO:0034141	positive regulation of toll-like receptor 3 signaling pathway	Biological Process		1
GO:0034137	positive regulation of toll-like receptor 2 signaling pathway	Biological Process	IMP[19509286]	1
GO:0034134	toll-like receptor 2 signaling pathway	Biological Process		10
GO:0034130	toll-like receptor 1 signaling pathway	Biological Process		10
GO:0032760	positive regulation of tumor necrosis factor production	Biological Process	IMP[16301656]	9
GO:2000340	positive regulation of chemokine (C-X-C motif) ligand 1 production	Biological Process		1
GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	Biological Process		2
GO:0090023	positive regulation of neutrophil chemotaxis	Biological Process		5
GO:0090073	positive regulation of protein homodimerization activity	Biological Process	IDA[12062447]	2
GO:0071221	cellular response to bacterial lipopeptide	Biological Process		1
GO:0071223	cellular response to lipoteichoic acid	Biological Process		2
GO:0070374	positive regulation of ERK1 and ERK2 cascade	Biological Process	IMP[11544529]	22
GO:0070935	3'-UTR-mediated mRNA stabilization	Biological Process	IDA[15294994]	2
GO:0050830	defense response to Gram-positive bacterium	Biological Process		6
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process	IMP[19509286]	27
GO:0046330	positive regulation of JNK cascade	Biological Process	IMP[11544529]	12
GO:0046982	protein heterodimerization activity	Molecular Function	IDA[19509286]	68

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05152	Tuberculosis	30	Tuberculosis, or TB, is an infectious disease caused by Myco...... Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection. More...
hsa04620	Toll-like receptor signaling pathway	13	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK. More...

Genes shared at least 5 GO terms with TIRAP (count: 22)

Gene Symbol	Pathway Count	Pathway List
TLR4	20	MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; protein binding; positive regulation of interleukin-12 production; positive regulation of interleukin-8 production; positive regulation of B cell proliferation; response to lipopolysaccharide; I-kappaB kinase/NF-kappaB cascade; Toll signaling pathway; plasma membrane; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; toll-like receptor 4 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; positive regulation of tumor necrosis factor production; cellular response to lipoteichoic acid; positive regulation of ERK1 and ERK2 cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of JNK cascade;
UBB	12	MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; protein binding; I-kappaB kinase/NF-kappaB cascade; Toll signaling pathway; plasma membrane; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; toll-like receptor 4 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; positive regulation of NF-kappaB transcription factor activity;
UBC	12	MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; protein binding; I-kappaB kinase/NF-kappaB cascade; Toll signaling pathway; plasma membrane; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; toll-like receptor 4 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; positive regulation of NF-kappaB transcription factor activity;
RELA	11	MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; protein binding; Toll signaling pathway; inflammatory response; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; toll-like receptor 4 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; positive regulation of NF-kappaB transcription factor activity;
MAP2K3	9	MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; protein binding; Toll signaling pathway; inflammatory response; innate immune response; toll-like receptor 4 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway;
MAPK3	9	MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; protein binding; Toll signaling pathway; innate immune response; toll-like receptor 4 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway; positive regulation of ERK1 and ERK2 cascade;
MAPK1	8	MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; protein binding; Toll signaling pathway; innate immune response; toll-like receptor 4 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway;
MAPK7	8	MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; protein binding; Toll signaling pathway; innate immune response; toll-like receptor 4 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway;
MAPK9	8	MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; protein binding; Toll signaling pathway; innate immune response; toll-like receptor 4 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 1 signaling pathway;
PYCARD	8	protein binding; inflammatory response; innate immune response; protein homodimerization activity; positive regulation of tumor necrosis factor production; positive regulation of ERK1 and ERK2 cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of JNK cascade;
MIF	7	protein binding; positive regulation of B cell proliferation; inflammatory response; cell surface receptor signaling pathway; innate immune response; positive regulation of chemokine (C-X-C motif) ligand 2 production; positive regulation of ERK1 and ERK2 cascade;
CCL19	7	positive regulation of interleukin-12 production; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of tumor necrosis factor production; positive regulation of neutrophil chemotaxis; positive regulation of ERK1 and ERK2 cascade; positive regulation of JNK cascade;
IL12B	6	protein binding; positive regulation of interleukin-12 production; negative regulation of growth of symbiont in host; protein homodimerization activity; positive regulation of tumor necrosis factor production; protein heterodimerization activity;
PRKD1	6	protein binding; plasma membrane; inflammatory response; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity;
BDKRB2	5	protein binding; plasma membrane; inflammatory response; cell surface receptor signaling pathway; protein heterodimerization activity;
FADD	5	protein binding; positive regulation of interleukin-8 production; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of tumor necrosis factor production;
MALT1	5	protein binding; plasma membrane; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity;
MAVS	5	protein binding; positive regulation of interleukin-8 production; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of tumor necrosis factor production;
PRKCB	5	protein binding; protein kinase C binding; plasma membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity;
RIPK3	5	protein binding; I-kappaB kinase/NF-kappaB cascade; plasma membrane; innate immune response; positive regulation of NF-kappaB transcription factor activity;
TRIM5	5	protein binding; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein homodimerization activity; positive regulation of NF-kappaB transcription factor activity;
IL6	5	response to lipopolysaccharide; inflammatory response; positive regulation of ERK1 and ERK2 cascade; defense response to Gram-positive bacterium; positive regulation of NF-kappaB transcription factor activity;

Genes shared at least 2 KEGG pathways with TIRAP (count: 8)

Gene Symbol	Pathway Count	Pathway List
FADD	2	Tuberculosis; Toll-like receptor signaling pathway;
IL12B	2	Tuberculosis; Toll-like receptor signaling pathway;
IL6	2	Tuberculosis; Toll-like receptor signaling pathway;
MAPK1	2	Tuberculosis; Toll-like receptor signaling pathway;
MAPK3	2	Tuberculosis; Toll-like receptor signaling pathway;
MAPK9	2	Tuberculosis; Toll-like receptor signaling pathway;
RELA	2	Tuberculosis; Toll-like receptor signaling pathway;
TLR4	2	Tuberculosis; Toll-like receptor signaling pathway;

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Region: chr11:126152960..126168740 View in gBrowse