ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MAVS
Symbol Alias	VISA, KIAA1271, IPS-1, Cardif
Approved Name	mitochondrial antiviral signaling protein
Name Alias	"virus-induced signaling adaptor", "IFN-B promoter stimulator 1", "CARD adaptor inducing IFN-beta"
Location	20p13
Position	chr20:3827487-3849280, 1
External Links	HGNC: 29233 Entrez Gene: 57506 Ensembl: ENSG00000088888 UCSC: uc002wjw.4
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_35	chr20:3036010-3839896 (NCBI Build 36.1 (hg18))	803887	20p13	Loss	De novo

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 32)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005778	peroxisomal membrane	cellular component	IDA	8
GO:0071360	cellular response to exogenous dsRNA	biological process	IMP[16127453]	1
GO:0051607	defense response to virus	biological process	IDA	16
GO:0032757	positive regulation of interleukin-8 production	biological process	IDA[16127453]	6
GO:0016021	integral to membrane	cellular component	IEA	932
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	biological process	IMP[12761501]	28
GO:0042993	positive regulation of transcription factor import into nucleus	biological process	IDA[18818105]	1
GO:0019901	protein kinase binding	molecular function	IPI[16127453]	59
GO:0045087	innate immune response	biological process	IMP[19631370]; TAS	57
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	biological process	IDA[16127453]	12
GO:0032727	positive regulation of interferon-alpha production	biological process	IDA[16127453]; IMP[19609254]	3
GO:0019048	virus-host interaction	biological process	IEA	61
GO:0031966	mitochondrial membrane	cellular component	IDA	12
GO:0005741	mitochondrial outer membrane	cellular component	IDA[18818105]; TAS	22
GO:0050700	CARD domain binding	molecular function	IPI[16127453]	2
GO:0032728	positive regulation of interferon-beta production	biological process	IDA[16127453]; IMP[19631370]	4
GO:0002218	activation of innate immune response	biological process	IMP[18818105]	3
GO:0033160	positive regulation of protein import into nucleus, translocation	biological process	IDA[18818105]	3
GO:0002230	positive regulation of defense response to virus by host	biological process	IDA[16127453]; IMP[19609254]	3
GO:0007165	signal transduction	biological process	IMP	189
GO:0001934	positive regulation of protein phosphorylation	biological process	IDA[16127453]	24
GO:0042742	defense response to bacterium	biological process	IMP[19631370]	13
GO:1900063	regulation of peroxisome organization	biological process	IMP	1
GO:0071660	positive regulation of IP-10 production	biological process	IDA[16127453]	1
GO:0032480	negative regulation of type I interferon production	biological process	TAS	10
GO:0060340	positive regulation of type I interferon-mediated signaling pathway	biological process	IDA[16127453]	3
GO:0004871	signal transducer activity	molecular function	IMP	56
GO:0005515	protein binding	molecular function	IPI[16127453]	1015
GO:0032760	positive regulation of tumor necrosis factor production	biological process	IDA[16127453]	10
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[18818105]	141
GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	biological process	IDA[16127453]	1
GO:0045071	negative regulation of viral genome replication	biological process	IDA	4

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MAVS (count: 20)

Gene Symbol	Pathway Count	Pathway List
FADD	9	defense response to virus; positive regulation of interleukin-8 production; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; virus-host interaction; positive regulation of type I interferon-mediated signaling pathway; protein binding; positive regulation of tumor necrosis factor production; positive regulation of transcription from RNA polymerase II promoter;
TLR4	9	positive regulation of interleukin-8 production; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; defense response to bacterium; protein binding; positive regulation of tumor necrosis factor production; positive regulation of transcription from RNA polymerase II promoter;
PYCARD	8	defense response to virus; innate immune response; positive regulation of sequence-specific DNA binding transcription factor activity; activation of innate immune response; positive regulation of defense response to virus by host; signal transduction; protein binding; positive regulation of tumor necrosis factor production;
TLR9	8	positive regulation of interleukin-8 production; integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; positive regulation of interferon-beta production; defense response to bacterium; positive regulation of tumor necrosis factor production; positive regulation of transcription from RNA polymerase II promoter;
RELA	7	defense response to virus; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein kinase binding; innate immune response; virus-host interaction; protein binding; positive regulation of transcription from RNA polymerase II promoter;
TRIM5	6	defense response to virus; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; virus-host interaction; activation of innate immune response; protein binding;
IRF7	6	innate immune response; positive regulation of interferon-alpha production; positive regulation of interferon-beta production; positive regulation of type I interferon-mediated signaling pathway; protein binding; positive regulation of transcription from RNA polymerase II promoter;
BNIP3	5	defense response to virus; virus-host interaction; mitochondrial membrane; mitochondrial outer membrane; protein binding;
TIRAP	5	positive regulation of interleukin-8 production; positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; protein binding; positive regulation of tumor necrosis factor production;
TRIM13	5	integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction; signal transducer activity; protein binding;
TNFRSF11A	5	integral to membrane; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of sequence-specific DNA binding transcription factor activity; signal transduction; protein binding;
UBB	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; negative regulation of type I interferon production; protein binding; positive regulation of transcription from RNA polymerase II promoter;
PRKD1	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; signal transduction; protein binding; positive regulation of transcription from RNA polymerase II promoter;
NEK6	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; protein kinase binding; signal transduction; signal transducer activity; protein binding;
GJA1	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; mitochondrial outer membrane; signal transduction; signal transducer activity; protein binding;
UBC	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; innate immune response; negative regulation of type I interferon production; protein binding; positive regulation of transcription from RNA polymerase II promoter;
SYK	5	protein kinase binding; innate immune response; virus-host interaction; defense response to bacterium; protein binding;
CREBBP	5	innate immune response; virus-host interaction; signal transduction; signal transducer activity; protein binding;
NLRX1	5	innate immune response; virus-host interaction; mitochondrial outer membrane; negative regulation of type I interferon production; protein binding;
MAPK3	5	innate immune response; virus-host interaction; positive regulation of protein phosphorylation; protein binding; positive regulation of transcription from RNA polymerase II promoter;

Genes shared at least 2 KEGG pathways with MAVS (count: 0)

View in gBrowse

Region: chr20:3827487..3849280 View in gBrowse