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KEGG Pathway Report
Basic Info
| ID | hsa05162 |
|---|---|
| Name | Measles |
| Description | Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacterial infections. Several MV proteins have been suggested to disturb host immunity. After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems. Three proteins (P, V, and C) associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis. Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation. |
| No. of Genes in ADHDgene | 20 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 20)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| GSK3B | glycogen synthase kinase 3 beta | 3q13.3 | 1(1/0/0) |
Genes from other sources (count: 19)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| MAVS | mitochondrial antiviral signaling protein | 20p13 | Mapped by CNV |
| IL12B | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 5q31.1-q33.1 | Mapped by significant region |
| CD3G | CD3g molecule, gamma (CD3-TCR complex) | 11q23 | Mapped by significant region |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 6q23-q25 | Mapped by significant region |
| IL6 | interleukin 6 (interferon, beta 2) | 7p21-p15 | Mapped by significant region |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 11q23 | Mapped by significant region |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | 11q23 | Mapped by significant region |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 11q13 | Mapped by significant region |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 1q23.3 | Mapped by CNV |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| HSPA8 | heat shock 70kDa protein 8 | 11q24.1 | Mapped by significant region |
| TLR4 | toll-like receptor 4 | 9q33.1 | Mapped by significant region |
| CCND1 | cyclin D1 | 11q13 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | 1q23 | Mapped by CNV |
| IRF7 | interferon regulatory factor 7 | 11p15.5 | Mapped by LD-proxy |
| IFNGR1 | interferon gamma receptor 1 | 6q23-q24 | Mapped by significant region |
| IRF9 | interferon regulatory factor 9 | 14q11.2 | Mapped by significant region |
| RCHY1 | ring finger and CHY zinc finger domain containing 1 | 4q21.1-q21.3 | Mapped by CNV |