ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	BDKRB2
Symbol Alias	BK-2
Approved Name	bradykinin receptor B2
Location	14q32.1-q32.2
Position	chr14:96671016-96710666, 1
External Links	HGNC: 1030 Entrez Gene: 624 Ensembl: ENSG00000168398 UCSC: uc010avm.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0031702	type 1 angiotensin receptor binding	molecular function	IPI[10993080]	2
GO:0004435	phosphatidylinositol phospholipase C activity	molecular function	TAS[8302267]	20
GO:0006954	inflammatory response	biological process	IC[17077303]	54
GO:0007204	elevation of cytosolic calcium ion concentration	biological process	TAS[10653985]	21
GO:0046982	protein heterodimerization activity	molecular function	IPI[10993080]	73
GO:0005886	plasma membrane	cellular component	IDA[17077303]; TAS	839
GO:0009651	response to salt stress	biological process	IEA	3
GO:0002020	protease binding	molecular function	IPI[17077303]	13
GO:0006939	smooth muscle contraction	biological process	IC[17077303]	10
GO:0043114	regulation of vascular permeability	biological process	IC[17077303]	2
GO:0019229	regulation of vasoconstriction	biological process	IC[17077303]	3
GO:0005515	protein binding	molecular function	IPI[18672896]	1015
GO:0007166	cell surface receptor signaling pathway	biological process	TAS[7916737]	36
GO:0008015	blood circulation	biological process	NAS[7835885]	12
GO:0004947	bradykinin receptor activity	molecular function	IDA[17077303]	1
GO:0050482	arachidonic acid secretion	biological process	IDA[17077303]	7
GO:0005887	integral to plasma membrane	cellular component	TAS[7916737]	236
GO:0033137	negative regulation of peptidyl-serine phosphorylation	biological process	IEA	2
GO:0005768	endosome	cellular component	IDA[17077303]	29
GO:0043066	negative regulation of apoptotic process	biological process	IEA	85
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	biological process	TAS[10653985]	16
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[1314587]	77

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene
hsa04610	Complement and coagulation cascades	11
hsa04810	Regulation of actin cytoskeleton	49
hsa04080	Neuroactive ligand-receptor interaction	89
hsa04020	Calcium signaling pathway	66

Genes shared at least 5 GO terms with BDKRB2 (count: 20)

Gene Symbol	Pathway Count	Pathway List
CCR5	9	phosphatidylinositol phospholipase C activity; inflammatory response; elevation of cytosolic calcium ion concentration; plasma membrane; protein binding; cell surface receptor signaling pathway; integral to plasma membrane; endosome; G-protein coupled receptor signaling pathway;
C3AR1	7	phosphatidylinositol phospholipase C activity; inflammatory response; elevation of cytosolic calcium ion concentration; plasma membrane; blood circulation; integral to plasma membrane; G-protein coupled receptor signaling pathway;
EDNRA	7	phosphatidylinositol phospholipase C activity; elevation of cytosolic calcium ion concentration; plasma membrane; smooth muscle contraction; integral to plasma membrane; negative regulation of apoptotic process; G-protein coupled receptor signaling pathway;
ADORA2A	7	inflammatory response; protein heterodimerization activity; plasma membrane; protein binding; blood circulation; integral to plasma membrane; transmembrane receptor protein tyrosine kinase signaling pathway;
PIK3CG	6	inflammatory response; elevation of cytosolic calcium ion concentration; plasma membrane; protein binding; negative regulation of apoptotic process; G-protein coupled receptor signaling pathway;
ADRA1A	6	elevation of cytosolic calcium ion concentration; protein heterodimerization activity; plasma membrane; smooth muscle contraction; integral to plasma membrane; G-protein coupled receptor signaling pathway;
ADRA2C	6	protein heterodimerization activity; plasma membrane; protein binding; integral to plasma membrane; endosome; G-protein coupled receptor signaling pathway;
CD3E	6	protein heterodimerization activity; plasma membrane; cell surface receptor signaling pathway; integral to plasma membrane; transmembrane receptor protein tyrosine kinase signaling pathway; G-protein coupled receptor signaling pathway;
CHRM3	5	phosphatidylinositol phospholipase C activity; plasma membrane; smooth muscle contraction; integral to plasma membrane; G-protein coupled receptor signaling pathway;
CASR	5	phosphatidylinositol phospholipase C activity; plasma membrane; protein binding; integral to plasma membrane; G-protein coupled receptor signaling pathway;
CCKBR	5	phosphatidylinositol phospholipase C activity; elevation of cytosolic calcium ion concentration; plasma membrane; cell surface receptor signaling pathway; integral to plasma membrane;
S1PR3	5	inflammatory response; elevation of cytosolic calcium ion concentration; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway;
TIRAP	5	inflammatory response; protein heterodimerization activity; plasma membrane; protein binding; cell surface receptor signaling pathway;
CXCR2	5	inflammatory response; elevation of cytosolic calcium ion concentration; plasma membrane; cell surface receptor signaling pathway; integral to plasma membrane;
LPAR1	5	elevation of cytosolic calcium ion concentration; plasma membrane; protein binding; integral to plasma membrane; G-protein coupled receptor signaling pathway;
ADRA2A	5	protein heterodimerization activity; plasma membrane; protein binding; integral to plasma membrane; G-protein coupled receptor signaling pathway;
ERBB2	5	protein heterodimerization activity; plasma membrane; protein binding; cell surface receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway;
ADRB2	5	plasma membrane; protein binding; cell surface receptor signaling pathway; integral to plasma membrane; endosome;
FLT4	5	plasma membrane; protein binding; integral to plasma membrane; negative regulation of apoptotic process; transmembrane receptor protein tyrosine kinase signaling pathway;
DRD3	5	plasma membrane; protein binding; arachidonic acid secretion; integral to plasma membrane; G-protein coupled receptor signaling pathway;

Genes shared at least 2 KEGG pathways with BDKRB2 (count: 29)

Gene Symbol	Pathway Count	Pathway List
CHRM5	3	Regulation of actin cytoskeleton; Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	3	Regulation of actin cytoskeleton; Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM3	3	Regulation of actin cytoskeleton; Neuroactive ligand-receptor interaction; Calcium signaling pathway;
C3AR1	2	Complement and coagulation cascades; Neuroactive ligand-receptor interaction;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;

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Region: chr14:96671016..96710666 View in gBrowse