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KEGG Pathway Report
Basic Info
| ID | hsa05142 |
|---|---|
| Name | Chagas disease (American trypanosomiasis) |
| Description | Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they invade diverse host cells including cardiomyocytes. Establishment of infection depends on various parasite molecules such as cruzipain, oligopeptidase B, and trans-sialidase that activate Ca2+ signaling. Internalized parasites escape from the parasitophorous vacuole using secreted pore-forming TcTOX molecule and replicate in the cytosol. Multiplied parasites eventually lyse infected host cells and are released in the circulation. During these events, the parasites manipulate host innate immunity and elicit cardiomyocyte hypertrophy. T lymphocyte responses are also disturbed. |
| No. of Genes in ADHDgene | 23 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 23)
Literature-origin genes (count: 3)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 4p16.1 | 1(1/0/0) |
| GNAL | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type | 18p11.22-p11.21 | 1(1/0/0) |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | 16q13 | 1(0/1/0) |
Genes from other sources (count: 20)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| MAPK9 | mitogen-activated protein kinase 9 | 5q35 | Mapped by CNV |
| TGFBR1 | transforming growth factor, beta receptor 1 | 9q22 | Mapped by significant region |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| FADD | Fas (TNFRSF6)-associated via death domain | 11q13.3 | Mapped by significant region |
| IL12B | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 5q31.1-q33.1 | Mapped by significant region |
| CD3G | CD3g molecule, gamma (CD3-TCR complex) | 11q23 | Mapped by significant region |
| PLCB2 | phospholipase C, beta 2 | 15q15 | Mapped by PBA pathway |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| IL6 | interleukin 6 (interferon, beta 2) | 7p21-p15 | Mapped by significant region |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 11q23 | Mapped by significant region |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | 11q23 | Mapped by significant region |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 11q13 | Mapped by significant region |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| TLR4 | toll-like receptor 4 | 9q33.1 | Mapped by significant region |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 11q23.1 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| BDKRB2 | bradykinin receptor B2 | 14q32.1-q32.2 | Mapped by PBA pathway |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 11q13 | Mapped by significant region |
| IFNGR1 | interferon gamma receptor 1 | 6q23-q24 | Mapped by significant region |
| PPP2R2D | protein phosphatase 2, regulatory subunit B, delta | 10q26.3 | Mapped by CNV |