ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GNAO1
Symbol Alias	G-ALPHA-o
Approved Name	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Location	16q13
Position	chr16:56225302-56391356, 1
External Links	HGNC: 4389 Entrez Gene: 2775 Ensembl: ENSG00000087258 UCSC: uc002eit.4
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Turic D, 2004 (b)	3 sequence variants were found in this gene, but none of them achieved even suggestive evidence for association.	Non-significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 3)

Variant Name	Variant Type	No. of Studies (significant/non-significant/trend)
GNAO1_IVS4+22T>C	point mutation	1 (0/1/0)
GNAO1_T(T)513C(T)	point mutation	1 (0/1/0)
GNAO1_-1214G>A	point mutation	1 (0/1/0)

Gene related regions (count: 0)

Gene related GO terms (count: 27)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051430	corticotropin-releasing hormone receptor 1 binding	molecular function	IEA	1
GO:0031852	mu-type opioid receptor binding	molecular function	IEA	1
GO:0031175	neuron projection development	biological process	IEA	11
GO:0005886	plasma membrane	cellular component	TAS	839
GO:0006936	muscle contraction	biological process	TAS[9050846]	18
GO:0030900	forebrain development	biological process	IEA	10
GO:0042542	response to hydrogen peroxide	biological process	IEA	7
GO:0007626	locomotory behavior	biological process	IEA	26
GO:0043005	neuron projection	cellular component	IEA	38
GO:0006184	GTP catabolic process	biological process	IBA; TAS[1899283]	24
GO:0007212	dopamine receptor signaling pathway	biological process	IBA	3
GO:0034097	response to cytokine stimulus	biological process	IEA	11
GO:0051926	negative regulation of calcium ion transport	biological process	IEA	4
GO:0004871	signal transducer activity	molecular function	IBA	56
GO:0008016	regulation of heart contraction	biological process	IEA	8
GO:0042493	response to drug	biological process	IEA	73
GO:0005525	GTP binding	molecular function	IEA	64
GO:0046872	metal ion binding	molecular function	IEA	200
GO:0031821	G-protein coupled serotonin receptor binding	molecular function	IBA	2
GO:0043547	positive regulation of GTPase activity	biological process	IEA	12
GO:0031234	extrinsic to internal side of plasma membrane	cellular component	IBA	5
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological process	IBA	14
GO:0043278	response to morphine	biological process	IEA	9
GO:0031683	G-protein beta/gamma-subunit complex binding	molecular function	IBA	5
GO:0005834	heterotrimeric G-protein complex	cellular component	IBA	9
GO:0007568	aging	biological process	IEA	29
GO:0003924	GTPase activity	molecular function	IBA	46

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04730	Long-term depression	27
hsa04916	Melanogenesis	18

Genes shared at least 5 GO terms with GNAO1 (count: 6)

Gene Symbol	Pathway Count	Pathway List
GNAZ	11	plasma membrane; GTP catabolic process; signal transducer activity; GTP binding; metal ion binding; G-protein coupled serotonin receptor binding; extrinsic to internal side of plasma membrane; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; G-protein beta/gamma-subunit complex binding; heterotrimeric G-protein complex; GTPase activity;
GNAT2	10	plasma membrane; GTP catabolic process; signal transducer activity; GTP binding; metal ion binding; extrinsic to internal side of plasma membrane; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; G-protein beta/gamma-subunit complex binding; heterotrimeric G-protein complex; GTPase activity;
GNAL	9	plasma membrane; GTP catabolic process; signal transducer activity; GTP binding; metal ion binding; extrinsic to internal side of plasma membrane; G-protein beta/gamma-subunit complex binding; heterotrimeric G-protein complex; GTPase activity;
CRYAB	5	plasma membrane; muscle contraction; response to hydrogen peroxide; metal ion binding; aging;
GNG10	5	plasma membrane; GTP catabolic process; signal transducer activity; heterotrimeric G-protein complex; GTPase activity;
GNG3	5	plasma membrane; GTP catabolic process; signal transducer activity; heterotrimeric G-protein complex; GTPase activity;

Genes shared at least 2 KEGG pathways with GNAO1 (count: 4)

Gene Symbol	Pathway Count	Pathway List
PLCB3	2	Long-term depression; Melanogenesis;
MAPK3	2	Long-term depression; Melanogenesis;
PLCB2	2	Long-term depression; Melanogenesis;
MAPK1	2	Long-term depression; Melanogenesis;

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Region: chr16:56225302..56391356 View in gBrowse