ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GNAZ
Approved Name	guanine nucleotide binding protein (G protein), alpha z polypeptide
Location	22q11.1-q11.2
Position	chr22:23412540-23467224, +
External Links	HGNC: 4395 Entrez Gene: 2781 Ensembl: ENSG00000128266 UCSC: uc002zwu.1
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Turic D, 2004 (b)	4 sequence variants were found in this gene, but none of them achieved even suggestive evidence for association.	Non-significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 4)

Variant Name	Variant Type	No. of Studies (significant/non-significant/trend)
GNAZ_2418A>G	point mutation	1 (0/1/0)
GNAZ_2529T>C	point mutation	1 (0/1/0)
GNAZ_1368G>C	point mutation	1 (0/1/0)
GNAZ_1479A>G	point mutation	1 (0/1/0)

Gene related regions (count: 0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0046872	metal ion binding	Molecular Function		170
GO:0031683	G-protein beta/gamma-subunit complex binding	Molecular Function		4
GO:0031821	G-protein coupled serotonin receptor binding	Molecular Function		2
GO:0005834	heterotrimeric G-protein complex	Cellular Component		7
GO:0005829	cytosol	Cellular Component		447
GO:0006184	GTP catabolic process	Biological Process	TAS[2117645]	22
GO:0005886	plasma membrane	Cellular Component		772
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	Biological Process		13
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[3129724]	72
GO:0031234	extrinsic to internal side of plasma membrane	Cellular Component		5
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	Biological Process		6
GO:0004871	signal transducer activity	Molecular Function		49
GO:0003924	GTPase activity	Molecular Function		41
GO:0005525	GTP binding	Molecular Function		53
GO:0005057	receptor signaling protein activity	Molecular Function	TAS[2456569]	9
GO:0005783	endoplasmic reticulum	Cellular Component	TAS[2117645]	100
GO:0005635	nuclear envelope	Cellular Component	TAS[2117645]	19

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04730	Long-term depression	27	Cerebellar long-term depression (LTD), thought to be a molec...... Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple signal transduction pathways have been shown to be involved in this process. Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse. This may take place either through receptor internalization and/or through receptor desensitization. More...

Genes shared at least 5 GO terms with GNAZ (count: 7)

Gene Symbol	Pathway Count	Pathway List
GNAO1	11	metal ion binding; G-protein beta/gamma-subunit complex binding; G-protein coupled serotonin receptor binding; heterotrimeric G-protein complex; GTP catabolic process; plasma membrane; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; extrinsic to internal side of plasma membrane; signal transducer activity; GTPase activity; GTP binding;
GNAT2	11	metal ion binding; G-protein beta/gamma-subunit complex binding; heterotrimeric G-protein complex; GTP catabolic process; plasma membrane; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; G-protein coupled receptor signaling pathway; extrinsic to internal side of plasma membrane; signal transducer activity; GTPase activity; GTP binding;
GNAL	10	metal ion binding; G-protein beta/gamma-subunit complex binding; heterotrimeric G-protein complex; GTP catabolic process; plasma membrane; extrinsic to internal side of plasma membrane; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; signal transducer activity; GTPase activity; GTP binding;
GNG10	6	heterotrimeric G-protein complex; GTP catabolic process; plasma membrane; G-protein coupled receptor signaling pathway; signal transducer activity; GTPase activity;
GNG3	6	heterotrimeric G-protein complex; GTP catabolic process; plasma membrane; G-protein coupled receptor signaling pathway; signal transducer activity; GTPase activity;
RAB14	5	cytosol; GTP catabolic process; plasma membrane; GTPase activity; GTP binding;
RHOD	5	cytosol; GTP catabolic process; plasma membrane; GTPase activity; GTP binding;

Genes shared at least 2 KEGG pathways with GNAZ (count: 0)

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Region: chr22:23412540..23467224 View in gBrowse