ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GNG10
Approved Name	guanine nucleotide binding protein (G protein), gamma 10
Location	9q31.3
Position	chr9:114423615-114432526, +
External Links	HGNC: 4402 Entrez Gene: 2790 Ensembl: ENSG00000242616
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q31.1-33.1	chr9:102600000-122500000	1 (1/0/0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006184	GTP catabolic process	Biological Process	TAS[7665596]	22
GO:0007165	signal transduction	Biological Process	TAS[7665596]	171
GO:0005886	plasma membrane	Cellular Component		772
GO:0006112	energy reserve metabolic process	Biological Process		25
GO:0004871	signal transducer activity	Molecular Function		49
GO:0005834	heterotrimeric G-protein complex	Cellular Component		7
GO:0003924	GTPase activity	Molecular Function	TAS[7665596]	41
GO:0071377	cellular response to glucagon stimulus	Biological Process		5
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0007268	synaptic transmission	Biological Process		96
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process		72

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04062	Chemokine signaling pathway	32	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. More...
hsa04724	Glutamatergic synapse	43	Glutamate is the major excitatory neurotransmitter in the ma...... Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synaptic cleft, glutamate acts on postsynaptic ionotropic glutamate receptors (iGluRs) to mediate fast excitatory synaptic transmission. Glutamate can also act on metabotropic glutamate receptors (mGluRs) and exert a variety of modulatory effects through their coupling to G proteins and the subsequent recruitment of second messenger systems. Presynaptically localized Group II and Group III mGluRs are thought to represent the classical inhibitory autoreceptor mechanism that suppresses excess glutamate release. After its action on these receptors, glutamate can be removed from the synaptic cleft by EAATs located either on the presynaptic terminal, neighboring glial cells, or the postsynaptic neuron. In glia, glutamate is converted to glutamine, which is then transported back to the presynaptic terminal and converted back to glutamate. More...

Genes shared at least 5 GO terms with GNG10 (count: 9)

Gene Symbol	Pathway Count	Pathway List
GNG3	10	GTP catabolic process; plasma membrane; energy reserve metabolic process; signal transducer activity; heterotrimeric G-protein complex; GTPase activity; cellular response to glucagon stimulus; small molecule metabolic process; synaptic transmission; G-protein coupled receptor signaling pathway;
GNAL	7	GTP catabolic process; signal transduction; plasma membrane; signal transducer activity; heterotrimeric G-protein complex; GTPase activity; synaptic transmission;
GNAT2	6	GTP catabolic process; plasma membrane; signal transducer activity; heterotrimeric G-protein complex; GTPase activity; G-protein coupled receptor signaling pathway;
GNAZ	6	GTP catabolic process; plasma membrane; signal transducer activity; heterotrimeric G-protein complex; GTPase activity; G-protein coupled receptor signaling pathway;
ADCY4	6	signal transduction; plasma membrane; energy reserve metabolic process; cellular response to glucagon stimulus; small molecule metabolic process; synaptic transmission;
GNAO1	5	GTP catabolic process; plasma membrane; signal transducer activity; heterotrimeric G-protein complex; GTPase activity;
ADRA2A	5	signal transduction; plasma membrane; energy reserve metabolic process; small molecule metabolic process; G-protein coupled receptor signaling pathway;
CHRM3	5	signal transduction; plasma membrane; energy reserve metabolic process; small molecule metabolic process; G-protein coupled receptor signaling pathway;
PRKAR2B	5	signal transduction; plasma membrane; energy reserve metabolic process; cellular response to glucagon stimulus; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with GNG10 (count: 9)

Gene Symbol	Pathway Count	Pathway List
ADCY4	2	Chemokine signaling pathway; Glutamatergic synapse;
ADRBK1	2	Chemokine signaling pathway; Glutamatergic synapse;
ADRBK2	2	Chemokine signaling pathway; Glutamatergic synapse;
GNG3	2	Chemokine signaling pathway; Glutamatergic synapse;
MAPK1	2	Chemokine signaling pathway; Glutamatergic synapse;
MAPK3	2	Chemokine signaling pathway; Glutamatergic synapse;
PLCB2	2	Chemokine signaling pathway; Glutamatergic synapse;
PLCB3	2	Chemokine signaling pathway; Glutamatergic synapse;
PRKCB	2	Chemokine signaling pathway; Glutamatergic synapse;

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Region: chr9:114423615..114432526 View in gBrowse