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KEGG Pathway Report
Basic Info
| ID | hsa04724 |
|---|---|
| Name | Glutamatergic synapse |
| Description | Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synaptic cleft, glutamate acts on postsynaptic ionotropic glutamate receptors (iGluRs) to mediate fast excitatory synaptic transmission. Glutamate can also act on metabotropic glutamate receptors (mGluRs) and exert a variety of modulatory effects through their coupling to G proteins and the subsequent recruitment of second messenger systems. Presynaptically localized Group II and Group III mGluRs are thought to represent the classical inhibitory autoreceptor mechanism that suppresses excess glutamate release. After its action on these receptors, glutamate can be removed from the synaptic cleft by EAATs located either on the presynaptic terminal, neighboring glial cells, or the postsynaptic neuron. In glia, glutamate is converted to glutamine, which is then transported back to the presynaptic terminal and converted back to glutamate. |
| No. of Genes in ADHDgene | 43 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 43)
Literature-origin genes (count: 13)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| ADRBK2 | adrenergic, beta, receptor kinase 2 | 22q11 | 1(0/1/0) |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | 21q22 | 1(0/0/1) |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | 16q13 | 1(0/1/0) |
| GRM5 | glutamate receptor, metabotropic 5 | 11q14.3 | 2(1/0/1) |
| GRIK4 | glutamate receptor, ionotropic, kainate 4 | 11q | 1(0/1/0) |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 5p13 | 2(1/1/0) |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 16p13.2 | 3(1/2/0) |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 12p12 | 1(1/0/0) |
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | 12p13.3 | 1(0/1/0) |
| GRM7 | glutamate receptor, metabotropic 7 | 3p26-p25 | 1(1/0/0) |
| GRM8 | glutamate receptor, metabotropic 8 | 7q31.3-q32.1 | 1(1/0/0) |
| GRM1 | glutamate receptor, metabotropic 1 | 6q24 | 1(1/0/0) |
| ADRBK1 | adrenergic, beta, receptor kinase 1 | 11q13 | 1(0/1/0) |
Genes from other sources (count: 30)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 11q13.2 | Mapped by significant region |
| PRKCB | protein kinase C, beta | 16p12 | Mapped by significant region |
| GRIN3A | glutamate receptor, ionotropic, N-methyl-D-aspartate 3A | 9q | Mapped by significant region |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 1p35 | Mapped by PBA pathway |
| PLA2G1B | phospholipase A2, group IB (pancreas) | 12q23-qter | Mapped by PBA pathway |
| PLA2G2E | phospholipase A2, group IIE | 1p36.13 | Mapped by PBA pathway |
| PLA2G2D | phospholipase A2, group IID | 1p36.12 | Mapped by PBA pathway |
| GRIA4 | glutamate receptor, ionotrophic, AMPA 4 | 11q22 | Mapped by significant region |
| PLA2G4B | phospholipase A2, group IVB (cytosolic) | 15q11.2-q21.3 | Mapped by PBA pathway |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 3p26.1 | Mapped by CNV |
| PLA2G3 | phospholipase A2, group III | 22q12.2 | Mapped by PBA pathway |
| PLA2G5 | phospholipase A2, group V | 1p36-p34 | Mapped by PBA pathway |
| TRPC1 | transient receptor potential cation channel, subfamily C, member 1 | 3q23 | Mapped by PBA pathway |
| PLCB2 | phospholipase C, beta 2 | 15q15 | Mapped by PBA pathway |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) | 22q13.1 | Mapped by PBA pathway |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| PLD1 | phospholipase D1, phosphatidylcholine-specific | 3q26 | Mapped by PBA pathway |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 19p13 | Mapped by PBA pathway |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 12p11.23 | Mapped by LD-proxy; Mapped by literature SNP |
| GLUL | glutamate-ammonia ligase | 1q31 | Mapped by significant region |
| PPP3R2 | protein phosphatase 3, regulatory subunit B, beta | 9q31 | Mapped by significant region |
| GRM6 | glutamate receptor, metabotropic 6 | 5q35 | Mapped by CNV |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | 3p14.3 | Mapped by PBA pathway |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| GNG3 | guanine nucleotide binding protein (G protein), gamma 3 | 11p11 | Mapped by significant region |
| GNG10 | guanine nucleotide binding protein (G protein), gamma 10 | 9q31.3 | Mapped by significant region |
| PLA2G10 | phospholipase A2, group X | 16p13.1-p12 | Mapped by PBA pathway; Mapped by significant region |
| PLD2 | phospholipase D2 | 17p13.3 | Mapped by PBA pathway |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 11q13 | Mapped by significant region |
| ADCY4 | adenylate cyclase 4 | 14q11.2 | Mapped by significant region |