ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PLA2G2A
Previous Symbol	PLA2B, PLA2L
Approved Name	phospholipase A2, group IIA (platelets, synovial fluid)
Location	1p35
Position	chr1:20301925-20306932, -1
External Links	HGNC: 9031 Entrez Gene: 5320 Ensembl: ENSG00000188257 UCSC: uc010odb.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005509	calcium ion binding	molecular function	IEA	140
GO:0050729	positive regulation of inflammatory response	biological process	TAS[18827909]	9
GO:0036149	phosphatidylinositol acyl-chain remodeling	biological process	TAS	8
GO:0046474	glycerophospholipid biosynthetic process	biological process	TAS	30
GO:0046473	phosphatidic acid metabolic process	biological process	IDA[9032461]	1
GO:0005576	extracellular region	cellular component	TAS	267
GO:0036152	phosphatidylethanolamine acyl-chain remodeling	biological process	TAS	15
GO:0010744	positive regulation of macrophage derived foam cell differentiation	biological process	TAS[18827909]	5
GO:0050830	defense response to Gram-positive bacterium	biological process	TAS[18827909]	6
GO:0034374	low-density lipoprotein particle remodeling	biological process	TAS[18827909]	1
GO:0047498	calcium-dependent phospholipase A2 activity	molecular function	TAS[9272153]	5
GO:0030141	secretory granule	cellular component	IEA	17
GO:0006644	phospholipid metabolic process	biological process	IDA[17069818]; TAS	61
GO:0005543	phospholipid binding	molecular function	IDA[9032461]	66
GO:0005789	endoplasmic reticulum membrane	cellular component	TAS	159
GO:0005615	extracellular space	cellular component	IDA[17069818]	133
GO:0006654	phosphatidic acid biosynthetic process	biological process	TAS	12
GO:0004623	phospholipase A2 activity	molecular function	IDA[17069818]; TAS	10
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0005783	endoplasmic reticulum	cellular component	IDA	111
GO:0036151	phosphatidylcholine acyl-chain remodeling	biological process	TAS	15
GO:0036150	phosphatidylserine acyl-chain remodeling	biological process	TAS	10
GO:0036148	phosphatidylglycerol acyl-chain remodeling	biological process	TAS	10
GO:0016042	lipid catabolic process	biological process	IEA	32

Gene related KEGG pathways (count: 10)

ID	Name	No. of Genes in ADHDgene
hsa04370	VEGF signaling pathway	18
hsa04010	MAPK signaling pathway	68
hsa04664	Fc epsilon RI signaling pathway	19
hsa04730	Long-term depression	27
hsa00564	Glycerophospholipid metabolism	21
hsa04912	GnRH signaling pathway	30
hsa00592	alpha-Linolenic acid metabolism	10
hsa00591	Linoleic acid metabolism	11
hsa00590	Arachidonic acid metabolism	15
hsa00565	Ether lipid metabolism	13

Genes shared at least 5 GO terms with PLA2G2A (count: 23)

Gene Symbol	Pathway Count	Pathway List
PLA2G1B	15	calcium ion binding; phosphatidylinositol acyl-chain remodeling; glycerophospholipid biosynthetic process; extracellular region; phosphatidylethanolamine acyl-chain remodeling; calcium-dependent phospholipase A2 activity; secretory granule; phospholipid metabolic process; extracellular space; phosphatidic acid biosynthetic process; phospholipase A2 activity; small molecule metabolic process; phosphatidylcholine acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling;
PLA2G10	14	calcium ion binding; phosphatidylinositol acyl-chain remodeling; glycerophospholipid biosynthetic process; extracellular region; phosphatidylethanolamine acyl-chain remodeling; positive regulation of macrophage derived foam cell differentiation; phospholipid metabolic process; phosphatidic acid biosynthetic process; phospholipase A2 activity; small molecule metabolic process; phosphatidylcholine acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; lipid catabolic process;
PLA2G5	13	calcium ion binding; phosphatidylinositol acyl-chain remodeling; glycerophospholipid biosynthetic process; extracellular region; phosphatidylethanolamine acyl-chain remodeling; calcium-dependent phospholipase A2 activity; phospholipid metabolic process; phosphatidic acid biosynthetic process; small molecule metabolic process; phosphatidylcholine acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; lipid catabolic process;
PLA2G2E	13	calcium ion binding; phosphatidylinositol acyl-chain remodeling; glycerophospholipid biosynthetic process; extracellular region; phosphatidylethanolamine acyl-chain remodeling; phospholipid metabolic process; phosphatidic acid biosynthetic process; phospholipase A2 activity; small molecule metabolic process; phosphatidylcholine acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; lipid catabolic process;
PLA2G2D	13	calcium ion binding; phosphatidylinositol acyl-chain remodeling; glycerophospholipid biosynthetic process; extracellular region; phosphatidylethanolamine acyl-chain remodeling; phospholipid metabolic process; phosphatidic acid biosynthetic process; phospholipase A2 activity; small molecule metabolic process; phosphatidylcholine acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; lipid catabolic process;
PLA2G3	11	calcium ion binding; glycerophospholipid biosynthetic process; extracellular region; phosphatidylethanolamine acyl-chain remodeling; calcium-dependent phospholipase A2 activity; phospholipid metabolic process; extracellular space; small molecule metabolic process; phosphatidylcholine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling; lipid catabolic process;
PLA2G4B	11	calcium ion binding; glycerophospholipid biosynthetic process; extracellular region; phosphatidylethanolamine acyl-chain remodeling; calcium-dependent phospholipase A2 activity; phospholipid metabolic process; phosphatidic acid biosynthetic process; small molecule metabolic process; phosphatidylcholine acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling;
LPCAT4	10	calcium ion binding; glycerophospholipid biosynthetic process; phosphatidylethanolamine acyl-chain remodeling; phospholipid metabolic process; endoplasmic reticulum membrane; phosphatidic acid biosynthetic process; small molecule metabolic process; phosphatidylcholine acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling;
PLA2G16	10	phosphatidylinositol acyl-chain remodeling; glycerophospholipid biosynthetic process; phosphatidylethanolamine acyl-chain remodeling; phospholipid metabolic process; phospholipase A2 activity; small molecule metabolic process; endoplasmic reticulum; phosphatidylcholine acyl-chain remodeling; phosphatidylserine acyl-chain remodeling; lipid catabolic process;
LPCAT1	9	calcium ion binding; glycerophospholipid biosynthetic process; phospholipid metabolic process; endoplasmic reticulum membrane; phosphatidic acid biosynthetic process; small molecule metabolic process; endoplasmic reticulum; phosphatidylcholine acyl-chain remodeling; phosphatidylglycerol acyl-chain remodeling;
PLA2G4C	8	phosphatidylinositol acyl-chain remodeling; glycerophospholipid biosynthetic process; phosphatidylethanolamine acyl-chain remodeling; phospholipid metabolic process; phospholipid binding; endoplasmic reticulum membrane; small molecule metabolic process; phosphatidylcholine acyl-chain remodeling;
PLA2G6	7	glycerophospholipid biosynthetic process; phosphatidylethanolamine acyl-chain remodeling; phospholipid metabolic process; phospholipase A2 activity; small molecule metabolic process; phosphatidylcholine acyl-chain remodeling; lipid catabolic process;
PLD1	7	glycerophospholipid biosynthetic process; defense response to Gram-positive bacterium; phospholipid metabolic process; endoplasmic reticulum membrane; phosphatidic acid biosynthetic process; small molecule metabolic process; lipid catabolic process;
MBOAT1	6	glycerophospholipid biosynthetic process; phosphatidylethanolamine acyl-chain remodeling; phospholipid metabolic process; endoplasmic reticulum membrane; small molecule metabolic process; phosphatidylserine acyl-chain remodeling;
PNPLA8	6	glycerophospholipid biosynthetic process; phosphatidylethanolamine acyl-chain remodeling; phospholipid metabolic process; endoplasmic reticulum membrane; small molecule metabolic process; phosphatidylcholine acyl-chain remodeling;
MBOAT2	6	glycerophospholipid biosynthetic process; phosphatidylethanolamine acyl-chain remodeling; phospholipid metabolic process; endoplasmic reticulum membrane; small molecule metabolic process; phosphatidylcholine acyl-chain remodeling;
PLD2	6	glycerophospholipid biosynthetic process; phospholipid metabolic process; endoplasmic reticulum membrane; phosphatidic acid biosynthetic process; small molecule metabolic process; lipid catabolic process;
PLD3	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; endoplasmic reticulum membrane; small molecule metabolic process; lipid catabolic process;
ACHE	5	glycerophospholipid biosynthetic process; extracellular region; phospholipid metabolic process; extracellular space; small molecule metabolic process;
DGAT2	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; endoplasmic reticulum membrane; small molecule metabolic process; endoplasmic reticulum;
PNPLA3	5	glycerophospholipid biosynthetic process; phospholipid metabolic process; endoplasmic reticulum membrane; phospholipase A2 activity; small molecule metabolic process;
LPL	5	extracellular region; positive regulation of macrophage derived foam cell differentiation; phospholipid metabolic process; extracellular space; small molecule metabolic process;
APOA1	5	extracellular region; secretory granule; phospholipid binding; extracellular space; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with PLA2G2A (count: 30)

Gene Symbol	Pathway Count	Pathway List
PLA2G6	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
PLA2G2D	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
PLA2G5	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
PLA2G2E	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
PLA2G10	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
PLA2G4B	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
PLA2G1B	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
PLA2G3	10	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; Glycerophospholipid metabolism; GnRH signaling pathway; alpha-Linolenic acid metabolism; Linoleic acid metabolism; Arachidonic acid metabolism; Ether lipid metabolism;
MAPK3	5	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; GnRH signaling pathway;
MAPK1	5	VEGF signaling pathway; MAPK signaling pathway; Fc epsilon RI signaling pathway; Long-term depression; GnRH signaling pathway;
MAP2K3	3	MAPK signaling pathway; Fc epsilon RI signaling pathway; GnRH signaling pathway;
MAPK9	3	MAPK signaling pathway; Fc epsilon RI signaling pathway; GnRH signaling pathway;
PLD1	3	Glycerophospholipid metabolism; GnRH signaling pathway; Ether lipid metabolism;
PLD2	3	Glycerophospholipid metabolism; GnRH signaling pathway; Ether lipid metabolism;
PPP3R2	2	VEGF signaling pathway; MAPK signaling pathway;
PIK3CG	2	VEGF signaling pathway; Fc epsilon RI signaling pathway;
NFATC4	2	VEGF signaling pathway; MAPK signaling pathway;
PLCG2	2	VEGF signaling pathway; Fc epsilon RI signaling pathway;
PIK3R1	2	VEGF signaling pathway; Fc epsilon RI signaling pathway;
CACNA1D	2	MAPK signaling pathway; GnRH signaling pathway;
MAPK7	2	MAPK signaling pathway; GnRH signaling pathway;
CACNA1A	2	MAPK signaling pathway; Long-term depression;
CACNA1C	2	MAPK signaling pathway; GnRH signaling pathway;
CACNA1F	2	MAPK signaling pathway; GnRH signaling pathway;
CACNA1S	2	MAPK signaling pathway; GnRH signaling pathway;
PLCB3	2	Long-term depression; GnRH signaling pathway;
ITPR2	2	Long-term depression; GnRH signaling pathway;
ITPR1	2	Long-term depression; GnRH signaling pathway;
PLCB2	2	Long-term depression; GnRH signaling pathway;
CYP2E1	2	Linoleic acid metabolism; Arachidonic acid metabolism;

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Region: chr1:20301925..20306932 View in gBrowse