ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0007186
Name G-protein coupled receptor signaling pathway
Type biological process
No. of Genes in ADHDgene  77
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 77)

Literature-origin genes (count: 20)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
GPR50 G protein-coupled receptor 50 Xq28 1(0/0/1) TAS[8647286]
GRM1 glutamate receptor, metabotropic 1 6q24 1(1/0/0) TAS[7476890]
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 22q11.1-q11.2 1(0/1/0) TAS[3129724]
DRD3 dopamine receptor D3 3q13.3 8(1/7/0) IDA[7911712]
RGS18 regulator of G-protein signaling 18 1q31.2 1(0/1/0) IEA
ADRA1A adrenoceptor alpha 1A 8p21.2 3(2/1/0) TAS[10860850]
ADRA1B adrenoceptor alpha 1B 5q33.3 2(1/1/0) TAS[2154750]
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 6q14-q15 2(2/0/0) TAS[1608964]
ADRA2B adrenoceptor alpha 2B 2q11.1 1(1/0/0) TAS[2164221]
ADRA1D adrenoceptor alpha 1D 20p13 1(0/1/0) TAS[1656955]
LPHN3 latrophilin 3 4q13.1 4(3/0/1) NAS[10994649]
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 1p13 1(1/0/0) NAS[2534964]
OXER1 oxoeicosanoid (OXE) receptor 1 2p22.1 1(0/0/1) NAS[12065583]
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5q31-q33 1(1/0/0) TAS[9351641]
GPR125 G protein-coupled receptor 125 4p15.31 1(0/1/0) TAS[15203201]
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 6q13 14(5/9/0) TAS[1315531]
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 7q36.1 1(0/1/0) TAS[7988681]
ADRA2C adrenoceptor alpha 2C 4p16.3 7(2/4/1) TAS[9371698]
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5q11.2-q13 2(2/0/0) TAS[1330092]
ADRA2A adrenoceptor alpha 2A 10q25.2 13(4/9/0) ISS[19965390]

Genes from other sources Help (count: 57)

Approved Symbol Approved Name Source Evidence[PMID]
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Mapped by CNV IDA[12507995]
GPR123 G protein-coupled receptor 123 Mapped by CNV TAS[15203201]
TAAR1 trace amine associated receptor 1 Mapped by significant region TAS[15718104]
NPW neuropeptide W Mapped by significant region IDA[12401809]
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) Mapped by CNV TAS[1325670]
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) Mapped by PBA pathway IMP[19523456]
S1PR3 sphingosine-1-phosphate receptor 3 Mapped by significant region TAS[10617617]
GPSM2 G-protein signaling modulator 2 Mapped by CNV TAS[8973305]
APOA1 apolipoprotein A-I Mapped by significant region IDA[16443932]
C3AR1 complement component 3a receptor 1 Mapped by PBA pathway TAS[8898085]
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 Mapped by significant region; Mapped by PBA pathway TAS[9169438]
CHRM1 cholinergic receptor, muscarinic 1 Mapped by significant region; Mapped by PBA pathway TAS[7925360]
SORT1 sortilin 1 Mapped by CNV IMP[18258592]
APLP2 amyloid beta (A4) precursor-like protein 2 Mapped by significant region NAS[8220435]
GNG10 guanine nucleotide binding protein (G protein), gamma 10 Mapped by significant region IEA
BCAR1 breast cancer anti-estrogen resistance 1 Mapped by significant region ISS; NAS[10092204]
SSTR5 somatostatin receptor 5 Mapped by significant region TAS[9892014]
C5 complement component 5 Mapped by significant region TAS[8898085]
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 Mapped by significant region TAS[9872316]
TAAR8 trace amine associated receptor 8 Mapped by significant region TAS[15718104]
XPR1 xenotropic and polytropic retrovirus receptor 1 Mapped by significant region TAS[9990033]
CXCR5 chemokine (C-X-C motif) receptor 5 Mapped by significant region TAS[1425907]
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 Mapped by CNV NAS[10907856]
CASR calcium-sensing receptor Mapped by PBA pathway TAS[7759551]
GNRHR gonadotropin-releasing hormone receptor Mapped by significant region TAS[8386108]
CD3E CD3e molecule, epsilon (CD3-TCR complex) Mapped by significant region TAS[8530500]
RGS11 regulator of G-protein signaling 11 Mapped by significant region IEA
CXCR1 chemokine (C-X-C motif) receptor 1 Mapped by significant region TAS[8381837]
TAAR9 trace amine associated receptor 9 (gene/pseudogene) Mapped by significant region TAS[15718104]
GPR21 G protein-coupled receptor 21 Mapped by significant region TAS[9073069]
GPRC5C G protein-coupled receptor, class C, group 5, member C Mapped by CNV TAS[10783259]
APLNR apelin receptor Mapped by significant region TAS[9792798]
TAAR5 trace amine associated receptor 5 Mapped by significant region TAS[15718104]
RXFP3 relaxin/insulin-like family peptide receptor 3 Mapped by significant region TAS[10806363]
EDNRA endothelin receptor type A Mapped by PBA pathway NAS[8611157]
BAIAP3 BAI1-associated protein 3 Mapped by significant region IPI[9790924]
CXCL12 chemokine (C-X-C motif) ligand 12 Mapped by PBA pathway TAS[8752280]
LPAR1 lysophosphatidic acid receptor 1 Mapped by significant region TAS[8922387]
CHRM3 cholinergic receptor, muscarinic 3 Mapped by CNV; Mapped by PBA pathway TAS[9603968]
NMU neuromedin U Mapped by LD-proxy TAS[10811630]
GPR139 G protein-coupled receptor 139 Mapped by significant region IDA[15845401]
PTGDR2 prostaglandin D2 receptor 2 Mapped by significant region IDA[11208866]
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 Mapped by CNV; Mapped by significant region IMP[16443932]
GNG3 guanine nucleotide binding protein (G protein), gamma 3 Mapped by significant region IEA
TAS2R1 taste receptor, type 2, member 1 Mapped by significant region TAS[10761934]
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 Mapped by significant region IDA[15755723]
TAAR2 trace amine associated receptor 2 Mapped by significant region TAS[15718104]
APOC3 apolipoprotein C-III Mapped by significant region IDA[16443932]
RASD1 RAS, dexamethasone-induced 1 Mapped by significant region TAS[10840027]
LTB4R leukotriene B4 receptor Mapped by significant region TAS[9177352]
GPR144 G protein-coupled receptor 144 Mapped by significant region TAS[15203201]
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like Mapped by CNV NAS[11072084]
INS insulin Mapped by Literature SNP IDA[9092559]
TAAR6 trace amine associated receptor 6 Mapped by significant region TAS[15718104]
SCTR secretin receptor Mapped by LD-proxy TAS[7612008]
GPR52 G protein-coupled receptor 52 Mapped by significant region TAS[9931487]
BDKRB2 bradykinin receptor B2 Mapped by PBA pathway TAS[1314587]